Patents by Inventor Patricia LaCroix

Patricia LaCroix has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
    Patent number: 7579167
    Abstract: The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of increasing the levels of production and the purity of the spiramycin produced. The invention relates in particular to a microorganism which produces spiramycin I but which does not produce spiramycin II and III, and to the use of such a microorganism. The invention also relates to the use of the genes of the biosynthetic pathway for spiramycins for constructing mutants which can lead to the synthesis of novel antibiotics or to derived forms of spiramycins. The invention also relates to the molecules produced through the expression of these genes and to pharmacologically active compositions of a molecule produced through the expression of such genes.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: August 25, 2009
    Assignees: Aventis Pharma S., Centre National de la Recherche Scientifique
    Inventors: Marie-Helene Blondelet-Rouault, Helene Dominguez, Emmanuelle Darbon-Rongere, Claude Gerbaud, Anne Gondran, Fatma Karray, Patricia Lacroix, Nathalie Oestreicher-Mermet-Bouvier, Pernodet Jean-Luc, Karine Tuphile
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 7090999
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: August 15, 2006
    Assignee: sanofi-aventis
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
    Publication number: 20050202528
    Abstract: The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of increasing the levels of production and the purity of the spiramycin produced. The invention relates in particular to a microorganism which produces spiramycin I but which does not produce spiramycin II and III, and to the use of such a microorganism. The invention also relates to the use of the genes of the biosynthetic pathway for spiramycins for constructing mutants which can lead to the synthesis of novel antibiotics or to derived forms of spiramycins. The invention also relates to the molecules produced through the expression of these genes and to pharmacologically active compositions of a molecule produced through the expression of such genes.
    Type: Application
    Filed: October 7, 2003
    Publication date: September 15, 2005
    Applicant: Aventis Pharma S.A.
    Inventors: Marie-Helene Blondelet-Rouault, Helene Dominguez, Emmanuelle Darbon-Rongere, Claude Gerbaud, Anne Gondran, Fatma Karray, Patricia Lacroix, Nathalie Oestreicher-Mermet-Bouvier, Jean-Luc Pernodet, Karine Tuphile
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Publication number: 20040229236
    Abstract: The invention concerns methods for preparing pristinamycin IIA or IIB.
    Type: Application
    Filed: November 20, 2003
    Publication date: November 18, 2004
    Applicant: Aventis Pharma
    Inventors: Veronique Blanc, Francis Blanche, Joerl Crouzet, Nathalie Jacoues, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6670157
    Abstract: The invention concerns methods for preparing pristinamycin IIB and methods for preparing modified pristinamycin IIB.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: December 30, 2003
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Streptomyces strains and process to produce single streptogramin component
    Patent number: 6180392
    Abstract: This invention relates to micro-organisms capable of selectively producing streptogramin components A and B, the preparation of said micro-organisms, and streptogramin A or B.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: January 30, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Genevi{grave over (e)}ve Barrere, Catherine Jumel, Patricia Lacroix, Corinne Lehmann, Alain Sabatier
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6171846
    Abstract: The invention concerns mutant microorganisms blocked in a step of Streptogramin biosynthesis and methods for preparing cells blocked in a step of Streptogramin biosynthesis.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: January 9, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia LaCroix, Denis Thibaut, Monique Zagorec, Laurent DeBussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 6077699
    Abstract: Disclosed is the nucleic acid sequences for polypeptides and enzymes involved in the biosynthesis of streptogramins from Streptomyces sp. and the corresponding amino acid sequences. Also disclosed are recombinant vectors and cells as well as methods of making the polypeptides, enzymes and streptogramins using the recombinant host cells.
    Type: Grant
    Filed: August 3, 1995
    Date of Patent: June 20, 2000
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard
  • Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use
    Patent number: 5891695
    Abstract: The invention concerns nucleotide sequences coding for a polypeptide involved in Streptogramin biosynthesis, recombinant cells containing said sequences, and use thereof.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: April 6, 1999
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Veronique Blanc, Francis Blanche, Joel Crouzet, Nathalie Jacques, Patricia Lacroix, Denis Thibaut, Monique Zagorec, Laurent Debussche, Valerie De Crecy-Lagard