Patents by Inventor Patricia R. Spilman

Patricia R. Spilman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3D-exoquant method for the analysis of surface molecules and quantification of tissue-specific exosomes in biological fluids
    Patent number: 11243215
    Abstract: In various embodiments methods are provided for identifying and/or quantifying one or more antigens of interest (biomarkers) on the surface of cell- or tissue-specific exosomes.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: February 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Varghese John, Jesus Campagna, Tina Bilousova, Patricia R. Spilman, Peter James Heinzelman, Asa Hatami, Mohammad Parvez Alam
  • DEFORMABLE NANO-SCALE VEHICLES (DNVS) FOR TRANS-BLOOD BRAIN BARRIER, TRANS-MUCOSAL, AND TRANSDERMAL DRUG DELIVERY
    Publication number: 20200030457
    Abstract: In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.
    Type: Application
    Filed: April 2, 2018
    Publication date: January 30, 2020
    Inventors: Varghese John, Ichiro Nishimura, Naren Subbiah, Jesus Campagna, Patricia R. Spilman, Mohammad Parvez Alam
  • COMPOUNDS TO PROMOTE NORMAL PROCESSING OF APP
    Publication number: 20190134000
    Abstract: In various embodiments, compositions and methods are provided for treatment and/or prevention of amyloidogenic diseases. In certain embodiments, the methods entail administering an effective amount of compound C41 to a subject in need thereof for prophylactic or therapeutic effect. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In certain embodiments, methods of reducing the risk, lessening the severity, or delaying the progression or onset of a disease characterized by beta-amyloid deposits in the brain of a mammal are also provided. In certain embodiments, methods of directly or indirectly enhances sAPP?, lowers A?, p-Tau, inhibits the C-terminal cleavage of APP resulting in the formation of APP-C31 peptide and APPneo (APP664) and improves memory in a mammal are provided.
    Type: Application
    Filed: May 11, 2017
    Publication date: May 9, 2019
    Inventors: Varghese John, Dale E. Bredesen, Patricia R. Spilman, Barbara Jagodzinska
  • 3D-EXOQUANT METHOD FOR THE ANALYSIS OF SURFACE MOLECULES AND QUANTIFICATION OF TISSUE-SPECIFIC EXOSOMES IN BIOLOGICAL FLUIDS
    Publication number: 20190025330
    Abstract: In various embodiments methods are provided for identifying and/or quantifying one or more antigens of interest (biomarkers) on the surface of cell- or tissue-specific exosomes.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Varghese John, Jesus Campagna, Tina Bilousova, Patricia R. Spilman, Peter James Heinzelman, Asa Hatami, Mohammad Parvez Alam
  • DEFORMABLE NANO-SCALE VEHICLES (DNVS) FOR TRANS-BLOOD BRAIN BARRIER, TRANS-MUCOSAL, AND TRANSDERMAL DRUG DELIVERY
    Publication number: 20180318216
    Abstract: In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.
    Type: Application
    Filed: November 17, 2016
    Publication date: November 8, 2018
    Inventors: Varghese John, Ichiro Nishimura, Naren Subbiah, Jesus Campagna, Patricia R. Spilman, Mohammad Parvez Alam