Patents by Inventor Patricia Sime

Patricia Sime has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING AND TREATING FIBROSIS
    Publication number: 20160025745
    Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.
    Type: Application
    Filed: July 30, 2015
    Publication date: January 28, 2016
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Jia Guo, Xin Lin, Steve Georas, Patricia Sime
  • Methods of diagnosing and treating fibrosis
    Patent number: 9107942
    Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: August 18, 2015
    Assignee: University of Rochester
    Inventors: Jia Guo, Xin Lin, Steve Georas, Patricia Sime
  • METHODS OF DIAGNOSING AND TREATING FIBROSIS
    Publication number: 20110286990
    Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.
    Type: Application
    Filed: November 2, 2009
    Publication date: November 24, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Jia Guo, Xin Lin, Steve Georas, Patricia Sime
  • Use of peroxisome proliferator-activated receptor gamma (ppary) and/or retinoic acid receptor (rxr) agonists to inhibit platelet functions
    Publication number: 20070135382
    Abstract: Methods of inhibiting mammalian platelet release of CD40 ligand, thromboxanes, or prostaglandin E2, or surface expression of CD40 ligand that involve contacting mammalian platelets with an effective amount of a PPAR? agonist, an RXR agonist, or a combination thereof. As a consequence of inhibiting CD40 ligand and thromboxane release, the present invention allows for inhibition of thrombus fon-nation by (or clotting activities of) activated platelets, as well as treating or preventing CD40 ligand-mediated conditions and/or thromboxane-mediated conditions. Use of PPAR? agonist, RXR agonist, and/or inducers of PPAR? agonist in preparing a stored blood product, and for diagnostic testing of patient samples is also disclosed.
    Type: Application
    Filed: October 22, 2004
    Publication date: June 14, 2007
    Inventors: Richard Phipps, Patricia Sime, Neil Blumberg