Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: The present disclosure provides an endoscopic apparatus and associated methods. The apparatus may include a steerable tool having a first flexible tube concentrically nested within a second flexible tube. The apparatus may include an end cap disposed on the steerable tool, an image sensor disposed on the end cap, and one or more light sources disposed on the end cap. The apparatus may be configured for accessing a region within a middle ear cavity of a patient. As such, the apparatus may further include a flexible tube, through which the steerable tool may extend, as well as a pre-curved rigid tube, through which the flexible tube may extend, thus allowing the apparatus to be deployed for middle ear access.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: A vehicle seating assembly is provided that includes a seatback and a seat that includes a seat frame and a support assembly. The support assembly is coupled to the seat frame and movable between an elevated position and a flattened position in response to an actuation force applied on the support assembly. The support assembly includes an extension member having a first end fixedly coupled to the seat frame and a second end rotatably coupled to the seat frame, and a plate having a first side rotatably coupled to the seat frame and a second side slidably coupled to the seat frame.

Abstract: A vehicle seating assembly includes a seat and a seatback. The seatback includes a frame that has opposing first and second frame members and first and second displaceable panels that are pivotably coupled to the first and second frame members. The first and second displaceable panels are movable between stored positions and deployed positions in response to a force exerted on the seatback.

Abstract: A vehicle seating assembly includes a seat and a seatback. The seatback includes a frame that has opposing first and second frame members and first and second displaceable panels that are pivotably coupled to the first and second frame members. The first and second displaceable panels are movable between stored positions and deployed positions in response to a force exerted on the seatback.

Abstract: A seating assembly is provided that includes a seating assembly frame that includes a seatback frame, and a seat frame. The seating assembly further includes a seatback panel coupled to an upper portion of the seatback frame and movable between a stored position relative to the seatback frame and an extended position relative to the seatback frame, and an adjustment mechanism coupled to the seatback panel and the seating assembly frame and movable between a first position and a second position in response to an actuating force.

Abstract: A vehicle seating assembly includes a seat and a seatback. The seatback includes a frame that has opposing first and second frame members and first and second displaceable panels that are pivotably coupled to the first and second frame members. The first and second displaceable panels are movable between stored positions and deployed positions in response to a force exerted on the seatback.

Abstract: A seating assembly is provided that includes a seating assembly frame that includes a seatback frame, and a seat frame. The seating assembly further includes a seatback panel coupled to an upper portion of the seatback frame and movable between a stored position relative to the seatback frame and an extended position relative to the seatback frame, and an adjustment mechanism coupled to the seatback panel and the seating assembly frame and movable between a first position and a second position in response to an actuating force.

Abstract: A seating assembly having a seating assembly frame that includes a seat frame and a seatback frame. The seating assembly includes an extension member coupled to the seat frame and movable in response to an actuating force between an extended position relative to the seat frame and a compressed position relative to the seat frame and including an end fixedly coupled to the seat frame and an end coupled to an adjustment device disposed on the seat frame.

Abstract: An asset inventory for a site location is conducted by providing a user with a mobile interface, collecting a site ID, collecting an equipment ID, collecting equipment asset information, associating the equipment ID and equipment asset information with the site ID, and storing the equipment asset information, equipment ID, and site ID in one or more data repositories. Site surveys are conducted based on a system comprising a server, one or more data repositories, a mobile data interface, a network, and a series of rules corresponding to service and maintenance of site equipment.

Abstract: Non-idealities of input circuitry of a receiver signal chain can significantly degrade the overall performance of the receiver signal chain. A digital nonlinearity correction (NLC) can be implemented in a receiver signal chain having an ADC. Digital NLC can be designed as a drop in signal preconditioner for existing RF ADC wideband receiver signal chains. A unique equalizer can compensate for a variety of mixer spurs. Accordingly, digital NLC can correct nonlinearities due to mixers and any amplifiers preceding or following the ADC, potentially improving receive chains performance by 15-25 dB. Such a digital NLC solution can be particularly beneficial in defense and instrumentation applications which demand the greatest performance.

Abstract: The systems and methods of the present disclosure provide highly deformable porous membrane culture systems and actuation methods for studying the effects of biomedical stretch on cultured tissue. A well plate can include a well having a first opening configured to receive an insert coupled to a deformable membrane. The well plate can include a gasket positioned within the well and configured to create a seal between the insert and the well when the insert is positioned in the well. The well plate can include a chamber defined beneath the well, the chamber configured to receive fluid media and to expose the fluid media to a surface of the deformable membrane when the insert is positioned in the well. The well plate can include an actuator configured to stretch the deformable membrane by a target amount of strain.

Abstract: A seating assembly having a seating assembly frame that includes a seat frame and a seatback frame. The seating assembly includes an extension member coupled to the seat frame and movable in response to an actuating force between an extended position relative to the seat frame and a compressed position relative to the seat frame and including an end fixedly coupled to the seat frame and an end coupled to an adjustment device disposed on the seat frame.

Abstract: A vehicle seating assembly is provided that includes a seatback and a seat that includes a seat frame and a support assembly. The support assembly is coupled to the seat frame and movable between an elevated position and a flattened position in response to an actuation force applied on the support assembly. The support assembly includes an extension member having a first end fixedly coupled to the seat frame and a second end rotatably coupled to the seat frame, and a plate having a first side rotatably coupled to the seat frame and a second side slidably coupled to the seat frame.

Abstract: A seating assembly is provided that includes a seating assembly frame that includes a seatback frame, and a seat frame. The seating assembly further includes a seatback panel coupled to an upper portion of the seatback frame and movable between a stored position relative to the seatback frame and an extended position relative to the seatback frame, and an adjustment mechanism coupled to the seatback panel and the seating assembly frame and movable between a first position and a second position in response to an actuating force.

Abstract: A seating assembly having a seating assembly frame that includes a seat frame and a seatback frame. The seating assembly includes an extension member coupled to the seat frame and movable in response to an actuating force between an extended position relative to the seat frame and a compressed position relative to the seat frame and including an end fixedly coupled to the seat frame and an end coupled to an adjustment device disposed on the seat frame.

Abstract: The present disclosure relates to the use of X-ray detector cassettes that may be abutted or overlapped to form a detector assembly suitable for imaging objects that are too large to image using a single X-ray detector cassette. Such a detector assembly may be customized in terms of the size and/or shape of the field-of-view (FOV). In certain embodiments the radiation-sensitive electronics (e.g., readout electronics) are positioned to the side of the X-ray detecting components (e.g., scintillator, TFT array, and so forth), allowing the cassette to be thin relative to other detector devices and allowing the electronics to remain outside the X-ray beam path.

Abstract: The present disclosure relates to the use of X-ray detector cassettes that may be abutted or overlapped to form a detector assembly suitable for imaging objects that are too large to image using a single X-ray detector cassette. Such a detector assembly may be customized in terms of the size and/or shape of the field-of-view (FOV). In certain embodiments the radiation-sensitive electronics (e.g., readout electronics) are positioned to the side of the X-ray detecting components (e.g., scintillator, TFT array, and so forth), allowing the cassette to be thin relative to other detector devices and allowing the electronics to remain outside the X-ray beam path.