Abstract: A sensor device for sensing endoluminal geometry may include an expandable element disposed on the distal region of a shaft. The expandable element may be configured to move a collapsed configuration and an expanded configuration. The expandable element may include one or more sensor elements configured to sense proximity of the sensor element to tissue. The sensor device may include an indicator configured to distinguish between contact of the sensor element with tissue, loss of contact and proximity of the sensor element to tissue.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a catheter shaft. An expandable member may be coupled to the catheter shaft. The expandable member may be capable of shifting between a folded configuration and an expanded configuration. A plurality of flexible elements may be attached to the expandable member, with a plurality of electrode assemblies disposed on the flexible elements. The flexible elements may have a grooved substrate.

Abstract: A renal nerve ablation device may include an elongate tubular member having a distal region. An expandable member may be coupled to the distal region. An electrode support may be coupled to the distal region of the elongate tubular member and extend over a body of the expandable member. The electrode support may be free of connection to the body of the expandable member. One or more electrodes may be coupled to the electrode support.

Abstract: A system for treating tissue includes a first fastener including a first anchoring element at a distal end thereof for anchoring the first fastener in a first target portion of tissue extending about a periphery of a tissue defect to be treated and a first suture extending from a proximal end thereof. The system also includes a second fastener including a second anchoring element at a distal end thereof for anchoring the second fastener in a second target portion of tissue extending about a periphery of a tissue defect to be treated and a second suture extending from a proximal end thereof. Furthermore, the system includes a cinch element disposed about both of the first and second sutures and slidable therealong such that a tension applied to the first and second sutures draws the first and second fasteners toward one another to close the tissue defect.

Abstract: A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

Abstract: An example medical device is disclosed. The device includes a tubular member having a lumen defined therein and a distal end portion, the distal end portion defining a guidewire port. The medical device also includes an expandable frame disposed along the distal end portion of the tubular member, the expandable frame being designed to shift between a first configuration and an expanded configuration. The frame includes a base, an end region and a plurality of struts extending between the base and the end region, the struts defining a plurality of apertures along the frame. The medical device also includes a cover attached to a portion of the frame and the cover is configured to cover one or more of the plurality of apertures such that the frame will align the guidewire port with an opening in a heart valve when the frame is positioned within a body lumen.

Abstract: A method of making a multi-lumen catheter may include disposing an outer surface of a mandrel against an outer surface of a first catheter; disposing a first heat shrink material around the first catheter and the mandrel; heating the first catheter and the mandrel to form a U-shaped channel along the outer surface of the first catheter; removing the first heat shrink material and the mandrel from the first catheter; placing a second catheter into the U-shaped channel; disposing a second heat shrink material around the first catheter and the second catheter such that the second catheter is retained within the U-shaped channel; and heating the first catheter and the second catheter to cause reflow between the first catheter and the second catheter to form the multi-lumen catheter.

Abstract: The disclosure pertains to mixtures of LaFeSiH magnetic nanoparticles having different Curie temperatures useful for improved inductive hyperthermia efficiency, injectable formulations containing the nanoparticles, and methods of raising the temperature of selected cells using the nanoparticles.

Abstract: A valve with a frame and valve leaflets that provide a sinus pocket. The valve provides for unidirectional flow of a liquid through the valve.

Abstract: A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling.

Abstract: An example implantable microparticle for delivering therapeutic heat treatment comprises a generally spherical body. The body may be formed from a first material comprising a biodegradable material and a second material comprising a Curie temperature material. The biodegradable material may be a non-Curie temperature material or have a Curie temperature lower than a Curie temperature of the Curie temperature material. The first material and the second material are mixed to form a composite having a Curie temperature in the range of 35° C. and 100° C.

Abstract: A catheter includes a flexible shaft having a distal end dimensioned for deployment within a patient's renal artery. A number of elongated resilient members are mounted along a longitudinal length of the distal end of the shaft, and are extensible radially from the shaft at regions defined between longitudinally spaced-apart engagement locations. One or more electrodes are mounted on each of the resilient members at the radially extensible regions. A number of conductors are electrically coupled to the electrodes and extend along the shaft of the catheter. The elongated resilient members are collapsible when encompassed within a lumen of an outer sheath and extensible radially outward from the shaft at the regions defined between the longitudinally spaced-apart engagement locations when the catheter and the resilient members are axially extended beyond the distal tip of the sheath. RF energy is delivered to the electrodes for ablating perivascular renal nerves.

Abstract: A valve with a frame and valve leaflets that provide a sinus pocket. The valve provides for unidirectional flow of a liquid through the valve.

Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

Abstract: The present disclosure provides occlusion devices which comprise (a) a self-expanding support frame having a longitudinal axis comprising a plurality of loops each having an orifice, the support frame being self-expandable from a constrained shape to an unconstrained shape, and (b) a covering material covering an orifice of at least one of the loops. Also provided are assemblies and kits that contain such occlusion devices, and methods of delivering such occlusion devices to a patient.

Abstract: A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling.

Abstract: A catheter includes a flexible shaft having a distal end dimensioned for deployment within a patient's renal artery. A number of elongated resilient members are mounted along a longitudinal length of the distal end of the shaft, and are extensible radially from the shaft at regions defined between longitudinally spaced-apart engagement locations. One or more electrodes are mounted on each of the resilient members at the radially extensible regions. A number of conductors are electrically coupled to the electrodes and extend along the shaft of the catheter. The elongated resilient members are collapsible when encompassed within a lumen of an outer sheath and extensible radially outward from the shaft at the regions defined between the longitudinally spaced-apart engagement locations when the catheter and the resilient members are axially extended beyond the distal tip of the sheath. RF energy is delivered to the electrodes for ablating perivascular renal nerves.

Abstract: Devices provided herein can include implantable transseptal flow control components adapted to be implanted in an opening in a septal wall. In a closed configuration, the implantable transseptal flow control components provided herein prevent blood from flowing through the opening. In an open configuration, the implantable transseptal flow control components provided herein allow blood to flow from the left atrium to the right atrium. In a closed configuration, implantable transseptal flow control components provided herein can be configured such that blood does not stagnate at a location proximate to a left atrium flow control component side when the pressure differential is below a second predetermined threshold pressure value. Implantable transseptal flow control components provided herein can remain in a closed configuration when a pressure differential between the left atrium and the right atrium is less than a first non-zero predetermined threshold pressure value.

Abstract: A delivery catheter includes a soft, atraumatic distal tip. The distal tip is configured to transition from a folded configuration to an unfolded configuration during delivery of a medical device. A wall thickness of the distal tip may be increased such that the distal tip is biased to remain in the unfolded configuration after delivery. Additionally, the increased wall thickness in a selected region of the distal tip may cause the distal tip to resist and/or prevent collapse of the distal tip during retrieval and/or repositioning of the medical device when the medical device comes into contact with a distal end of the catheter. The distal edge of the distal tip may be rounded so as to prevent the distal tip from damaging tissue during advancement of the catheter to a target location within a patient's body.