Abstract: Rapid surface enhanced Raman spectroscopy (SERS) assays for ultratrace pathogen detection are provided. One-particle and two-particle sensor assays (e.g., biosensor assays) are provided. In one implementation, for example, an assay forms and concentrates a DNA hybridization complex incorporating paramagnetic particles and Raman active noble metal (e.g., gold, silver and/or copper) nanoparticles (two-particle sensor) or noble metal coated paramagnetic particles that provide both a SERS substrate and magnetic capture ability in a single sensor particle via a noble metal-coated paramagnetic particle, such as a gold-coated paramagnetic particle (one-particle sensor).

Abstract: A book reading chair comprising a seat formed in a generally planar rectangular configuration with an upper surface, a lower surface, a front edge and a rear edge. The plane of the seat is positioned horizontally in the operative orientation. Two rear legs are vertically positioned and include coupling means at their uppermost extent for attachment to the seat near its rear edge. Two front legs are vertically positioned and include coupling devices for attachment to the seat. The front legs are positioned closer together than the rear legs and are affixed to the central portion of the seat near its front edge. An extension piece is formed as a generally planar member with a front surface and a rear surface. The extension piece is affixed to the seat and extends vertically upward a distance between about fifty percent and one hundred and fifty percent of the length of the legs. An arm rest is formed in a planar configuration and is positioned horizontally upon the uppermost extent of the extension piece.