Abstract: Methods for treating cancer patients with human platelet derived growth factor receptor alpha inhibiting compounds, in which the patient is identified as having a cancer that is human platelet derived growth factor receptor beta negative.

Abstract: An apparatus that forms bundles of glass articles includes a glass article infeed station including an infeed conveyor that continuously transports individual glass articles to a layer separating conveyor. The layer separating conveyor includes a conveyor belt that forms a layer of side-by-side glass articles. A robotic lift assembly is configured to place the layer of side-by-side glass articles together on a layer separation insert. The layer separation insert has side-by-side slots that each receive a single glass article of the layer of side-by-side glass articles.

Abstract: An asset management system is disclosed where a plurality of financial databases may connect with and be in communication with an asset management tool. The asset management tool is able to create an individual spending plan (scheduled distributions) and matching fixed income investment portfolio for a user based on inputted parameters with automatic distributions from the portfolio consistent with the individual spending plan occurring with a high degree of certainty. The asset management tool may communicate with the plurality of financial databases to put the individual spending plan and matching portfolio into action and is able to calculate and communicate an optimized surplus investment as a means of self-insuring so that the predefined schedule of distributions is met with the effective certainty one would expect from an insured/guaranteed income product.

Abstract: Collapsible containers are an attractive alternative to surface-tension propellant management devices (PMDs) for handling cryogenic liquids, as the collapsible container comparatively may 1) allow higher expulsion flow rates than vanes and sponges, 2) significantly reduce operational complexity, and 3) thermally insulate the propellant from environmental heat leaks. Furthermore, while historical cryogenic collapsible containers suffered from the low ductility of polymer films at cryogenic temperatures, the technology disclosed herein shows that the incorporation of folded patterns into the collapsible container substantially increases the reusability of the cryogenic PMD.

Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: A novel water-borne debris collection system integrated into a waterborne vessel for collecting surface and near surface debris in a body of water, such as a river, lake, or ocean. The apparatus may include a solid collection boom that projects laterally from a vessel and is partially submerged to act as a collection mechanism. The boom also facilitates the propulsion of the vessel by providing a barrier across which a differential water surface level may be created to drive the vessel forward. The apparatus may include a pumping system that draws water from the anterior side of the screen and for multiple purposes, including processing the collected water to remove plastics and other pollutant and debris material therefrom, and to transfer the water to the posterior side of the screen to create the differential water level for driving the vessel forward.

Abstract: A novel water-borne debris collection system integrated into a waterborne vessel for collecting surface and near surface debris in a body of water, such as a river, lake, or ocean. The apparatus may include a solid collection boom that projects laterally from a vessel and is partially submerged to act as a collection mechanism. The boom also facilitates the propulsion of the vessel by providing a barrier across which a differential water surface level may be created to drive the vessel forward. The apparatus may include a pumping system that draws water from the anterior side of the screen and for multiple purposes, including processing the collected water to remove plastics and other pollutant and debris material therefrom, and to transfer the water to the posterior side of the screen to create the differential water level for driving the vessel forward.

Abstract: A novel water-borne debris collection system integrated into a waterborne vessel for collecting surface and near surface debris in a body of water, such as a river, lake, or ocean. The apparatus may include a solid collection boom that projects laterally from a vessel and is partially submerged to act as a collection mechanism. The boom also facilitates the propulsion of the vessel by providing a barrier across which a differential water surface level may be created to drive the vessel forward. The apparatus may include a pumping system that draws water from the anterior side of the screen and for multiple purposes, including processing the collected water to remove plastics and other pollutant and debris material therefrom, and to transfer the water to the posterior side of the screen to create the differential water level for driving the vessel forward.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: Systems and methods are provided for an electroactuated adhesion system containing a dry adhesive material and at least two patterned electrodes. The two or more patterned electrodes may be capable of promoting or increasing adhesion of the electroactuated adhesion system while simultaneously preventing or mitigating the accumulation of dust, contaminants, or particulates on the surface of the adhesive material.

Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: An asset management system is disclosed where a plurality of financial databases may connect with and be in communication with an asset management tool. The asset management tool is able to create an individual spending plan (scheduled distributions) and matching fixed income investment portfolio for a user based on inputted parameters with automatic distributions from the portfolio consistent with the individual spending plan occurring with a high degree of certainty. The asset management tool may communicate with the plurality of financial databases to put the individual spending plan and matching portfolio into action and is able to calculate and communicate an optimized surplus investment as a means of self-insuring so that the predefined schedule of distributions is met with the effective certainty one would expect from an insured/guaranteed income product.

Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.

Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: A novel tank cryogenic-compatible composite pressure vessel that beneficially utilizes Vapor Cooled Shielding (VCS) is introduced to minimize thermal gradients along support structures and reduces heat loads on cryogenic systems. In particular, the configurations and mechanisms to be utilized herein include: providing for a desired number of passageways and a given thickness of the VCS, reducing the thermal conductivity of the VCS material, and increasing the cooling capacitance of the hydrogen vapors.

Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.

Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: In some embodiments the present invention provides influenza hemagglutinin (“HA”) polypeptides, proteins, and protein complexes that comprise a stalk domain that is engineered to facilitate maintenance of its native trimeric conformation, even if the head domain of the HA protein is removed or disrupted. In some embodiments, the present invention provides compositions comprising such polypeptides, proteins, and protein complexes, and methods of use of such proteins and compositions, for example as vaccine immunogens.