Patents by Inventor Patrick A. MAYES

Patrick A. MAYES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prognostic method
    Patent number: 11353458
    Abstract: Methods are provided for determining prognosis of multiple myeloma in a patient by measuring expression of BCMA in a sample. Also provided are methods for treating multiple myeloma by measuring expression of BCMA in a sample and administering an effective amount of an antigen binding protein that binds BCMA. Also provided are kits for measuring BCMA expression in a sample.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 7, 2022
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Danton Bounds, Jenny L. Craigen, William E. Fieles, Fiona M. Germaschewski, Gaelle Herledan, Lydia Lee, Patrick A. Mayes, Lee McCahon, Katherine (Nee Sully) Nevin, Jennifer Paterson, Manuel Rodriguez-Justo, Laura M. Seestaller-Wehr, James Tunstead, Kwee L. Yong
  • COMBINATION THERAPY
    Publication number: 20200190194
    Abstract: The present invention provides methods of treating cancer in a patient in need thereof, the method comprising administering to the patient an effective amount of an agent directed to human ICOS and an effective amount of an agent directed to human PD1 or human PD-L1 sequentially. The present invention also provides an anti-ICOS antibody or antigen binding fragment thereof and an anti-PD1 antibody or antigen binding fragment thereof for sequential use in treating cancer in a human in need thereof. The present invention provides an anti-ICOS antibody or antigen binding fragment thereof and an anti-PD-L1 antibody or antigen binding fragment thereof for sequential use in treating cancer in a human in need thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: June 18, 2020
    Inventors: Meixia BI, Christopher B. HOPSON, Patrick A. MAYES, Sapna YADA VILLI
  • COMBINATION THERAPY WITH ICOS AGONIST AND OX40 AGONIST TO TREAT CANCER
    Publication number: 20200190195
    Abstract: The present invention provides a combination of an anti-ICOS antibody or antigen binding portion thereof and an anti-OX40 antibody or antigen binding portion thereof. The present invention also provides method of treating cancer in a patient in need thereof comprising administering to the patient an effective amount of an anti-ICOS antibody and an effective amount of an anti-OX40 antibody or antigen binding portion thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: June 18, 2020
    Inventors: Christopher B. HOPSON, David J. KILIAN, Patrick A. MAYES, Sapna YADAYILLI, Niranjan YANAMANDRA
  • COMBINATION THERAPY WITH ICOS AGONIST AND OX40 AGONIST TO TREAT CANCER
    Publication number: 20200181275
    Abstract: The present invention provides methods of treating cancer in a patient in need thereof, the method comprising administering to the patient an effective amount of an agent directed to human ICOS and an effective amount of an agent directed to human OX40 sequentially. The present invention also provides an anti-ICOS antibody or antigen binding fragment thereof and an anti-OX40 antibody or antigen binding fragment thereof for sequential use in treating cancer in a human in need thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: June 11, 2020
    Inventors: Christopher B. HOPSON, David J. KILIAN, Patrick A. MAYES, Sapna YADAYILLI, Niranjan YANAMANDRA
  • COMBINATION TREATMENTS AND USES AND METHODS THEREOF
    Publication number: 20190256608
    Abstract: Disclosed herein are combinations of an antigen binding protein that binds BCMA with a antigen binding protein that bind to an immunomodulatory agents, such as PD-1 or OX40, pharmaceutical compositions thereof, uses thereof, and methods of treatment comprising administering said combinations, including uses in cancer.
    Type: Application
    Filed: December 1, 2016
    Publication date: August 22, 2019
    Inventors: Patrick A. MAYES, Laura M. SEESTALLER-WEHR, Lyuben TSVETKOV, Niranjan YANAMANDRA, Jingsong YANG
  • PROGNOSTIC METHOD
    Publication number: 20180306791
    Abstract: Methods are provided for determining prognosis of multiple myeloma in a patient by measuring expression of BCMA in a sample. Also provided are methods for treating multiple myeloma by measuring expression of BCMA in a sample and administering an effective amount of an antigen binding protein that binds BCMA. Also provided are kits for measuring BCMA expression in a sample.
    Type: Application
    Filed: October 28, 2016
    Publication date: October 25, 2018
    Inventors: Danton BOUNDS, Jenny L. CRAIGEN, William E. FIELES, Fiona M. GERMASCHEWSKI, Gaelle HERLEDAN, Lydia LEE, Patrick A. MAYES, Lee MCCAHON, Katherine (NEE SULLY) NEVIN, Jennifer PATERSON, Manuel RODRIGUEZ-JUSTO, Laura M. SEESTALLER-WEHR, James TUNSTEAD, Kwee L. YONG