Abstract: Provided herein are compounds of the Formula I: and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

Abstract: An engine friction monitor uses commanded torque and measured torque to provide a prognostic feature to identify failure modes of an engine that causes the engine from delivering the commanded torque.

Abstract: Systems and methods for informed mobility platform for an item processing supervisor within a distribution facility are disclosed. In one embodiment, a supervisor mobile terminal for electronically managing item processing activities associated with a distribution facility is provided. The terminal may include a transceiver circuit configured to wirelessly communicate with a server computer a plurality of sets of data relating to the item processing activities. The terminal may further include a user interface configured to display the plurality of sets of data and a controller in data communication with the transceiver circuit and the user interface. The controller may be configured to control the user interface to modify the at least one set of data and control the transceiver circuit to wirelessly communicate the modified data with the server computer such that the at least one set of data stored in the server computer is updated with the modified data.

Abstract: Management of pharmaceutical procurement for a pharmaceutical ordering location. A method includes determining a medication need and a drug product preference for an ordering location. The method includes identifying one or more drug products satisfying the medication need by communicating with one or more pharmaceutical suppliers and selecting at least one of the one or more drug products based on the drug product preference. The method includes generating a recommended order for the ordering location comprising the at least one of the one or more drug products.

Abstract: The present disclosure provides for a protective covering, which includes a cover portion, an elongated piece of fabric, a first coupling mechanism, and a weighted fixture. The cover portion is for a seat cushion. The elongated piece of fabric extends from the cover portion. The first coupling mechanism couples the cover portion to a first end of the elongated piece of fabric. The weighted fixture facilitates securing the elongated piece of fabric in place over the cover portion using gravity.

Abstract: A cooking appliance includes a cooktop and a burner mounted on the cooktop. At least one coupling member is coupled to the cooktop. A grate, a griddle, or a reversible griddle is selectively coupled to the at least one coupling member and is operable between a raised position and a lowered position when the grate, the griddle, or the reversible griddle, is engaged with the coupling member.

Abstract: A computing device includes an appliance status table to store at least one of reliability and performance data for one or more network functions virtualization (NFV) appliances and one or more legacy network appliances. The computing device includes a load controller to configure an Internet Protocol (IP) filter rule to select a packet for which processing of the packet is to be migrated from a selected one of the one or more legacy network appliances to a selected one of the one or more NFV appliances, and to update the appliance status table with received at least one of reliability and performance data for the one or more legacy network appliances and the one or more NFV appliances. The computing device includes a packet distributor to receive the packet, to select one of the one or more NFV appliances based at least in part on the appliance status table, and to send the packet to the selected NFV appliance. Other embodiments are described herein.

Abstract: A method of controlling an agricultural facility for housing a plurality of animals includes the step of regulating the environment within the agricultural facility with an automated building operational system. An automated thermal event controller is operationally coupled with the automated building operational system and generates a thermal event signal in response to a thermal event in progress, whereby the automated thermal event controller, upon receipt of the thermal event signal indicating that the thermal event is in progress, activates an alarm state. In the alarm state, the automated thermal event controller: sends an alarm signal to a system administrator; places the automated building operational system in a safety-mode condition for a first predetermined time interval; and places the automated building operational system in a normal-mode operational condition after the first predetermined time interval and if a confirmatory signal is not yet then received from the system administrator.

Abstract: Physical object boundary detection techniques and systems are described. In one example, an augmented reality module generates three dimensional point cloud data. This data describes depths at respective points within a physical environment that includes the physical object. A physical object boundary detection module is then employed to filter the point cloud data by removing points that correspond to a ground plane. The module then performs a nearest neighbor search to locate a subset of the points within the filtered point cloud data that correspond to the physical object. Based on this subset, the module projects the subset of points onto the ground plane to generate a two-dimensional boundary. The two-dimensional boundary is then extruded based on a height determined from a point having a maximum distance from the ground plane from the filtered cloud point data.

Abstract: The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure provides for a protective covering, which includes a cover portion, an elongated piece of fabric, a first coupling mechanism, and a weighted fixture. The cover portion is for a seat cushion. The elongated piece of fabric extends from the cover portion. The first coupling mechanism couples the cover portion to a first end of the elongated piece of fabric. The weighted fixture facilitates securing the elongated piece of fabric in place over the cover portion using gravity.

Abstract: Physical object boundary detection techniques and systems are described. In one example, an augmented reality module generates three dimensional point cloud data. This data describes depths at respective points within a physical environment that includes the physical object. A physical object boundary detection module is then employed to filter the point cloud data by removing points that correspond to a ground plane. The module then performs a nearest neighbor search to locate a subset of the points within the filtered point cloud data that correspond to the physical object. Based on this subset, the module projects the subset of points onto the ground plane to generate a two-dimensional boundary. The two-dimensional boundary is then extruded based on a height determined from a point having a maximum distance from the ground plane from the filtered cloud point data.

Abstract: A method and apparatus are disclosed for creating a puncture in a tissue. The assembly includes a puncturing device having a distal tip configured to deliver energy to the tissue, creating the puncture. The puncturing device further includes a marker positioned along the puncturing device. The assembly further includes a dilator which has a lumen extending from a proximal portion to a distal portion and configured to receive the puncturing device. The dilator further comprises a sensor positioned along a length of the dilator. When the marker and the sensor are aligned, energy is delivered to the distal tip of the puncturing device.

Abstract: A system comprising a generator which is capable of supplying energy for puncturing a tissue and an electrical current of known voltage, wherein the electrical current of known voltage can pass through the tissue without damaging the tissue. The system also includes a puncturing device comprising an elongate member. A distal tip of the elongate member comprises an energy delivery device which is configured for delivering the energy for puncturing and two electrodes which are configured for delivering the electrical current of known voltage from one electrode to the other through a material which is in contact with the distal tip. The system further includes a sensor which is capable of detecting a value of the electrical current between the two electrodes. The generator comprises a generator switch for disabling energy delivery tip based on the value of the electric current detected by the sensor.

Abstract: A system and method for receiving a request convert a representation of value into a value token. The system receiving an indication of the specific purchasing activity. The system determining a geographic location of the specific purchasing activity. The system converting the representation of value into the value token. The system pausing providing the value token for a period of time based on the geographic location of the specific purchasing activity.

Abstract: An interbody system including an implant and a tool for inserting and expanding the medical implant and locking the implant in place is disclosed. The medical implant may include an expandable body defined by a superior endplate and an inferior endplate that are hingedly coupled and may be expanded and lordosed. The superior and inferior endplate may include gripping protrusions that mate and/or directly engage with recessed jaws of disclosed surgical tool. The surgical tool may include a vertically movable jaw to expand and contract the implant when engaged with the gripping protrusions of the implant. The surgical tool may also include a drive portion that engages the drive feature of the lock screw with the drive end of the surgical tool lock the implant while in an expanded position.

Abstract: A method for calibrating at least one solid-state sensor coupled to an elongate body comprising an expandable member is described herein. In some variations, the method may include advancing the expandable member to a target location in a blood vessel of a patient, injecting a calibration bolus into the expandable member, obtaining, using a controller, a first sensor data from an expandable member sensor, obtaining, using the controller, a second sensor data from the at least one solid-state sensor, and adjusting the second sensor data based on the first sensor data.

Abstract: A puncturing device configured to create a puncture in a tissue comprising an elongate member comprising a proximal portion defining a longitudinal axis along the length of the elongate member. The elongate member further comprises a flexible distal portion of the that curves away from the longitudinal axis and a distal tip configured to deliver energy to the tissue. A sensing element placed on the flexible distal portion of the elongate member detects the curvature of the distal portion such that when the flexible distal portion of the elongate member is straightened, energy is delivered to the distal tip and when the flexible distal portion of the elongate member is curved, energy is not delivered to the distal tip.

Abstract: Physical object boundary detection techniques and systems are described. In one example, an augmented reality module generates three dimensional point cloud data. This data describes depths at respective points within a physical environment that includes the physical object. A physical object boundary detection module is then employed to filter the point cloud data by removing points that correspond to a ground plane. The module then performs a nearest neighbor search to locate a subset of the points within the filtered point cloud data that correspond to the physical object. Based on this subset, the module projects the subset of points onto the ground plane to generate a two-dimensional boundary. The two-dimensional boundary is then extruded based on a height determined from a point having a maximum distance from the ground plane from the filtered cloud point data.

Abstract: The apparatus and method for hemostasis that informs the provider as to whether the appropriate magnitude of pressure is being applied to a puncture site on a patient. A visual pulse indicator can visually convey whether or not there is proper blood flow at the puncture site based on the pulsing motion encountered by the visual pulse indicator on the puncture site. The visual pulse indicator can potentially factor in a variety of different input parameters in displaying information that is useful to providers.