Patents by Inventor Patrick A. Weiss

Patrick A. Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200222875
    Abstract: Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 16, 2020
    Inventors: Bill James PECK, Mary NOE, Stefan PITSCH, Patrick A. Weiss
  • Patent number: 7772439
    Abstract: An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure: is provided. Such building block may be introduced in the 5? end position of an amino acid under standard coupling conditions. Such building block allows in-line coupling control, “trityl-on” purification, and solid support functionalization/derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: August 10, 2010
    Assignee: Operon Biotechnologies, Inc.
    Inventors: Patrick A. Weiss, Violette Y. Weiss, Stefan Pitsch
  • Publication number: 20090203897
    Abstract: A method of synthesizing oligonucleotides is claimed. The method utilizes a synthesis column incorporating a filter-like porous polymer cartridge which contains derivatized Controlled Pore Glass (CPG) or cross-linked Polystyrene (PS) directly embedded into the polymer cartridge. Small-scale synthesis of oligonucleotides of a predetermined sequence may be accomplished by introducing reagents of the phosphoramidite method into the synthesis column. These reagents flow through the cartridge allowing the reaction sequence to take place on the derivatized CPG or PS incorporated within the polymer cartridge.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 13, 2009
    Applicant: Operon Biotechnologies, Inc.
    Inventors: Lance Larka, Philipp Wenter, Patrick A. Weiss
  • Patent number: 5986084
    Abstract: The ribonucleoside-derivatives serve for the synthesis of ribonucleic acids and comprise a triple substituted silyloxymethyl-group as a protection-group on the oxygen atom in 2'-position. The ribonucleoside-derivatives may be suitably protected on the nucleo-base and on the oxygen in 5'-position also. The new protection-groups in 2'-O-position are superior to conventional such protection-groups as they are not subject to isomerization and give higher coupling yields. The general formula of the ribonucleoside-derivative is: ##STR1## whereby R.sup.1 is a base of the purine- or pyrimidine-family or a derivative of such a base,R.sup.2 is a proton or a substituted derivative of phosphonic acid,R.sup.3 is a proton or a suitable protection-group,R.sup.4, R.sup.5, R.sup.6 are advantageously three identical or different alkyl- or aryl-substituents which together comprise between 6 and 30 carbon atoms.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: November 16, 1999
    Inventors: Stefan Pitsch, Patrick A. Weiss, Luzi Jenny