Abstract: In some embodiments, the present invention provides respiratory syncytial virus (RSV) F proteins, polypeptides and protein complexes that comprise one or more cross-links to stabilize the protein, polypeptide or protein complex in its pre-fusion conformation. In some embodiments the present invention provides RSV F proteins, polypeptides and protein complexes comprising one or more mutations to facilitate such cross-linking. In some embodiments the present invention provides compositions comprising such proteins, polypeptides or protein complexes, including vaccine compositions, and methods of making and using the same.

Abstract: A method and device for generating a stream of data that is representative of at least an algorithm (44) of a software as a medical device. To reach that aim, the method comprises designing (41) the at least an algorithm using first programming language items of a determined domain-specific language (DSL), which is obtained using a determined language workbench (LWB) environment. The method further comprises simulating (42) an executing of the at least an algorithm with a simulation environment obtained using second programming language items of the determined DSL, the simulating being implemented in the determined LWB environment; testing (43) the at least an algorithm with at least a test function written with third programming language items of the DSL, the testing being implemented in the determined LWB environment; and generating (440) the stream of data.

Abstract: A method and device for generating a stream of data that is representative of at least an algorithm (44) of a software as a medical device. To reach that aim, the method comprises designing (41) the at least an algorithm using first programming language items of a determined domain-specific language (DSL), which is obtained using a determined language workbench (LWB) environment. The method further comprises simulating (42) an executing of the at least an algorithm with a simulation environment obtained using second programming language items of the determined DSL, the simulating being implemented in the determined LWB environment; testing (43) the at least an algorithm with at least a test function written with third programming language items of the DSL, the testing being implemented in the determined LWB environment; and generating (440) the stream of data.