Patents by Inventor Patrick Allison

Patrick Allison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 6051227
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: April 18, 2000
    Assignee: The Regents of the University of California, Office of Technology Transfer
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel
  • Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 5855887
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: December 4, 1995
    Date of Patent: January 5, 1999
    Assignee: The Regents of the University of California
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel
  • Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
    Patent number: 5811097
    Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: September 22, 1998
    Assignee: The Regents of the University of California
    Inventors: James Patrick Allison, Dana R. Leach, Matthew F. Krummel
  • Saturated cellulosic substrate
    Patent number: 5780369
    Abstract: A saturated hydroentangled fibrous web which includes fibers and a saturant. The fibers include from about 20 to 100 percent by weight, based on the total weight of the fibers, of cellulosic fibers, and from 0 to about 70 percent by weight, based on the total weight of the fibers, of mercerized cellulosic fibers. From about 80 to 0 percent by weight of the fibers, based on the total weight of the fibers, are synthetic polymer fibers. Finally, at least 10 percent by weight of the fibers are mercerized cellulosic fibers, synthetic polymer fibers, or a mixture thereof. The saturant is present in the saturated fibrous web at a level of from about 25 to about 100 percent, based on the dry weight of the fibers. When synthetic polymer fibers are present in the web, the saturant may be adapted to wet synthetic polymer fibers. A second layer composed of a bonded nonwoven web may be present. Also provided is a method of preparing the saturated hydroentangled fibrous web.
    Type: Grant
    Filed: June 30, 1997
    Date of Patent: July 14, 1998
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: John Patrick Allison, Russell Lynn Dolsey