Patents by Inventor Patrick Angibaud

Patrick Angibaud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FARNESYL TRANSFERASE INHIBITING TRICYCLIC QUINAZOLINE DERIVATIVES SUBSTITUTED WITH CARBON-LINKED IMIDAZOLES OR TRIAZOLES
    Publication number: 20080027086
    Abstract: This invention comprises the novel compounds of formula (I) wherein r, s, t, R1, R2, R3, R4, R5, and R6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 31, 2008
    Inventors: Patrick Angibaud, Marc Venet, Jean Michel Argoullon
  • Diastereoselective Addition of Lithiated N-Methylimidazole on Sulfinimines
    Publication number: 20070293679
    Abstract: A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the preparation of a compound of formula (VIII) and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl-.
    Type: Application
    Filed: April 28, 2005
    Publication date: December 20, 2007
    Inventors: Walter Filliers, Rudy Broeckx, Patrick Angibaud
  • Diastereoselective Synthesis Process with 6-Bromo-4-(3-Chlorophenyl)-2-Methoxy-Quinoline
    Publication number: 20070293680
    Abstract: A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone which comprises the preparation of a compound of formula (XVII): and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl.
    Type: Application
    Filed: April 28, 2005
    Publication date: December 20, 2007
    Inventors: Walter Filliers, Rudy Broeckx, Patrick Angibaud
  • FARNESYL TRANSFERASE INHIBITING 1,2-ANNELATED QUINOLINE ENANTIOMER
    Publication number: 20070259902
    Abstract: (?)-5 -(3-Chlorophenyl)-?-(4-chlorophenyl)-?-(1-methyl-1H-imidazol-5 -yl)tetrazolo-[1,5-a]quinazoline-7-methanamine and its pharmaceutically acceptable acid addition salts, and the use of such compounds in medicine especially for the treatment of cancer
    Type: Application
    Filed: January 31, 2007
    Publication date: November 8, 2007
    Inventors: Marc Venel, Patrick Angibaud, David End
  • Diastereoselective Synthesis Process for the Preparation of Imidazole Compounds
    Publication number: 20070238880
    Abstract: A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4 -chlomphenyl)(I-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl2(IH)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with C1-6alkyloxy.
    Type: Application
    Filed: April 28, 2005
    Publication date: October 11, 2007
    Applicant: JANSSEN PHARMACEUTICA N.V.
    Inventors: Walter Filliers, Rudy Laurent Broeckx, Patrick Angibaud
  • SUBSTITUTED PROPENYL PIPERAZINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
    Publication number: 20070135424
    Abstract: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: January 23, 2007
    Publication date: June 14, 2007
    Inventors: Sven Franciscus Van Brandt, Kristof Van Emelen, Patrick Angibaud, Laurence Francoise Marconnet-Decrane, Janine Arts
  • Farnesyl transferase inhibiting 4-heterocyclyl-quinoline and quinazoline derivatives
    Publication number: 20060135769
    Abstract: This invention comprises the novel compounds of formula (I): wherein s, t, Y1, Y2, R1, R2, R3, R4, R5, R6 and R7have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 22, 2006
    Inventors: Patrick Angibaud, Marc Venet, Virginie Poncelet
  • 1,8-Annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
    Publication number: 20050176702
    Abstract: This invention comprises the novel compounds of formula (I) wherein r, s, A, X, Y1, Y2, R1, R2, R3, and R4 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: December 11, 2002
    Publication date: August 11, 2005
    Inventors: Patrick Angibaud, Marc Venet
  • Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050171347
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: August 4, 2005
    Inventors: Kristof Emelen, Leo Backx, Sven Van Brandt, Patrick Angibaud, Isabelle Noelle Pilatte, Marc Gustaaf Verdonck, Hans De Winter
  • Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
    Publication number: 20050171111
    Abstract: This invention comprises the novel compounds of formula (I) wherein r, t, Y1, Y2, R1, R2, R3, R5, R6and R7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 18, 2003
    Publication date: August 4, 2005
    Inventors: Patrick Angibaud, Marc, Gaston Venet, Christophe Meyer, Henry Breslin
  • Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles of triazoles
    Publication number: 20050148609
    Abstract: This invention comprises the novel compounds of formula (I) wherein r, s, t, R1, R2, R3, R4, R5, and R6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: April 14, 2003
    Publication date: July 7, 2005
    Inventor: Patrick Angibaud
  • Amino-derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050119250
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: June 2, 2005
    Inventors: Patrick Angibaud, Kristof Van Emelen, Virginie Poncelet, Bruno Roux
  • New inhibitors of histone deacetylase
    Publication number: 20050107384
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: May 19, 2005
    Inventors: Patrick Angibaud, Isabelle Pilatte, Sven Van Brandt, Bruno Roux, Peter Ten Holte, Marc Verdonick, Lieven Meerpoel, Alexey Dyatkin