Patents by Inventor Patrick, Arnoldus, Maria Van Buggenum

Patrick, Arnoldus, Maria Van Buggenum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process For The Preparation of 7 alpha-Methylsteroids
    Publication number: 20100204497
    Abstract: The invention relates to a process for the preparation of 7?-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C?CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Grignard reagent CH3MgX, X being a halogen, to the 4,6-unsaturated 3-ketosteroid of formula II, wherein R1 and R2 are as previously defined, comprising protecting the hydroxy group of the steroid of formula II with a trialkylsilyl group, followed by treating the hydroxy protected steroid with the Grignard reagent. The process of the invention is useful for the production of pharmacologically interesting steroids.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Inventors: Patrick Arnoldus Maria Van Buggenum, Johannes Stoelwinder, Martin Ostendorf
  • Process for the preparation of 7alpha-methylsteroids
    Publication number: 20050090476
    Abstract: The invention relates to a process for the preparation of 7?-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C?CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Grignard reagent CH3MgX, X being a halogen, to the 4,6-unsaturated 3-ketosteroid of formula II, wherein R1 and R2 are as previously defined, comprising protecting the hydroxy group of the steroid of formula II with a trialkylsilyl group, followed by treating the hydroxy protected steroid with the Grignard reagent. The process of the invention is useful for the production of pharmacologically interesting steroids.
    Type: Application
    Filed: January 14, 2003
    Publication date: April 28, 2005
    Inventors: Patrick, Arnoldus, Maria Van Buggenum, Johannes Stoelwinder, Martin Ostendorf