Abstract: The present disclosure provides a multiple chamber container that includes a container body sealed around a peripheral edge and having an outlet. The container also includes a first peel seal having a projecting portion and a second peel seal that isolates the outlet. The second peel seal may also include a projecting portion. The first and second peel seals may be configured to define a symmetrical chamber. The chamber may include an axis of symmetry extending between the first and second projecting portions. The chamber geometry of the container ensures a correct sequential opening of the first and second peel seals.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: A peritoneal dialysis system includes: (i) a fluid cassette including diaphragm operated first and second pump chambers; (ii) a first pressure sensor operable with the first pump chamber; (iii) a second pressure sensor operable with the second pump chamber; and (iv) a to-patient port of the cassette in fluid communication with the first and second pump chambers, wherein the first pressure sensor is located between the first pump chamber and the to-patient port and the second pressure sensor is located between the second pump chamber and the to-patient port.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: A port, a container and a method for accessing a port for injecting or withdrawing a liquid from the container are provided. The port may allow for the administration of, for example, a drug, to a patient and may be located on the container. The port has a septum having a target area. The port also has a support ring in contact with the septum. A cap is provided to protect the septum. The cap has a ring handle and allows for removal and exposure of the target area of the septum. A needle, for example, may be used to penetrate the septum allowing the addition or withdrawal of a liquid or other drug to or from the container.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: The present invention provides a peelable polymeric layer structure having a first sealant layer including an ethylene-containing polymer, and a second sealant layer including a polypropylene-containing polymer attached to the first sealant layer along a peelable seal. The present invention also provides an overpouch container including a first sidewall having a first sealant layer of an ethylene-containing polymer, and a second sidewall having a second sealant layer of a propylene containing polymer. The second sealant layer is attached to the first sealant layer along a peelable peripheral seal.

Abstract: The present invention provides a peelable polymeric layer structure having a first sealant layer including an ethylene-containing polymer, and a second sealant layer including a polypropylene-containing polymer attached to the first sealant layer along a peelable seal. The present invention also provides an overpouch container including a first sidewall having a first sealant layer of an ethylene-containing polymer, and a second sidewall having a second sealant layer of a propylene containing polymer. The second sealant layer is attached to the first sealant layer along a peelable peripheral seal.

Abstract: A formed, filled, and sealed container, access port and method for establishing fluid flow from the container to an administrative set is provided. The container is collapsible and has an inlet and an outlet. A hollow port is sealed to the container and a perforator inside the port pierces and becomes embedded in the container. Solution in the container is withdrawn into the port. A line attached to the port and an administrative set further establishes flow between the container and the administration set. The port may be operated with a single-hand to establish fluid flow from the container to the administrative set. After the perforator is embedded in the container, a lock on the port prevents the perforator from removal from the container. Activation of the lock produces an audible and/or visible notification.

Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.

Abstract: A port, a container and a method for accessing a port for injecting or withdrawing a liquid from the container are provided. The port may allow for the administration of, for example, a drug, to a patient and may be located on the container. The port has a septum having a target area. The port also has a support ring in contact with the septum. A cap is provided to protect the septum. The cap has a ring handle and allows for removal and exposure of the target area of the septum. A needle, for example, may be used to penetrate the septum allowing the addition or withdrawal of a liquid or other drug to or from the container.

Abstract: Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a sterile manner within a container with a gas barrier. The single solutions of the present invention can remain stable for three months or more. In this regard, the stable and single bicarbonate-based solutions of the present invention can be readily and effectively used during medical therapy, such as dialysis therapy.

Abstract: Peritoneal Dialysis systems, methods, and catheters are provided for performing peritoneal dialysis therapies. Multiple fluid pathways are provided to a patient's peritoneal cavity for conveying dialysis fluid to and from the patient.

Abstract: Peritoneal dialysis systems, methods, and catheters are provided for performing peritoneal dialysis therapies. Multiple fluid pathways are provided to a patient's peritoneal cavity for conveying dialysis fluid to and from the patient.

Abstract: An automated peritoneal dialysis system and method are provided for monitoring and controlling automated peritoneal dialysis therapy based upon intraperitoneal pressure measured at a point near the end of the patient catheter during the fill, dwell and drain phases of automated peritoneal dialysis therapy.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: Peritoneal dialysis systems, methods, and catheters are provided for performing peritoneal dialysis therapies. Multiple fluid pathways are provided to a patient's peritoneal cavity for conveying dialysis fluid to and from the patient.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.

Abstract: The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts—an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.