Patents by Inventor Patrick Berget

Patrick Berget has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IMPROVING PURITY OF TENOFOVIR DISOPROXIL FUMARATE, AND COMPOSITIONS THEREOF
    Publication number: 20210171556
    Abstract: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
    Type: Application
    Filed: November 25, 2020
    Publication date: June 10, 2021
    Inventors: John JACOBSEN, Valerie CALDWELL, Chris DICUS, Patrick BERGET
  • METHODS FOR IMPROVING PURITY OF TENOFOVIR DISOPROXIL FUMARATE, AND COMPOSITIONS THEREOF
    Publication number: 20210094977
    Abstract: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
    Type: Application
    Filed: November 25, 2020
    Publication date: April 1, 2021
    Inventors: John JACOBSEN, Valerie CALDWELL, Chris DICUS, Patrick BERGET
  • METHODS FOR IMPROVING PURITY OF TENOFOVIR DISOPROXIL FUMARATE, AND COMPOSITIONS THEREOF
    Publication number: 20200207793
    Abstract: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 2, 2020
    Inventors: John JACOBSEN, Valerie CALDWELL, Chris DICUS, Patrick BERGET
  • Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 9090539
    Abstract: Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: July 28, 2015
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Brian Morgan, Olivier Dapremont, Patrick Berget, Ali Suleman, William Dubay, Jeffrey D. Butler
  • Compounds and Methods for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds
    Publication number: 20140350283
    Abstract: Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 27, 2014
    Inventors: Brian MORGAN, Olivier DAPREMONT, Patrick BERGET, Ali SULEMAN, William DUBAY, Jeffrey D. BUTLER
  • Preparative-scale separation of enantiomers of chiral carboxylic acids
    Patent number: 8076511
    Abstract: High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: December 13, 2011
    Assignee: Ampac Fine Chemicals LLC.
    Inventors: Der-Shing Huang, Olivier Dapremont, Patrick Berget, Xa Her, Darin Sanchez
  • PREPARATIVE-SCALE SEPARATION OF ENANTIOMERS OF CHIRAL CARBOXYLIC ACIDS
    Publication number: 20080287704
    Abstract: High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.
    Type: Application
    Filed: May 18, 2007
    Publication date: November 20, 2008
    Applicant: AMPAC Fine Chemicals LLC
    Inventors: Der-Shing Huang, Olivier Dapremont, Patrick Berget, Xa Her, Darin Sanchez