Patents by Inventor Patrick Bhola

Patrick Bhola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput BH3 profiling: a rapid and scalable technology to BH3 profile on low numbers of cells
    Patent number: 11867688
    Abstract: The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: January 9, 2024
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan
  • LIVE CELL IMAGING DYNAMIC BH3 PROFILING
    Publication number: 20220163510
    Abstract: Aspects of the application provide methods and compositions for identifying and evaluating putative therapeutic agents for cancer by live cell imaging. Cell samples comprising cancerous cells that have been pre-treated with a test agent are contacted with a BH3 peptide, and samples are imaged by live cell imaging over a time interval. Methods of the application can be used to determine whether a patient is likely to benefit from treatment with a particular test agent.
    Type: Application
    Filed: February 26, 2020
    Publication date: May 26, 2022
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Rebecca German
  • COMPOSITIONS AND METHODS FOR ASSESSING TOXICITY USING DYNAMIC BH3 PROFILING
    Publication number: 20210255167
    Abstract: The present invention provides methods of assessing toxicity using Dynamic BH3 profiling.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 19, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan
  • HIGH THROUGHPUT BH3 PROFILING: A RAPID AND SCALABLE TECHNOLOGY TO BH3 PROFILE ON LOW NUMBERS OF CELLS
    Publication number: 20210041419
    Abstract: The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.
    Type: Application
    Filed: July 27, 2020
    Publication date: February 11, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan
  • High throughput BH3 profiling: a rapid and scalable technology to BH3 profile on low numbers of cells
    Patent number: 10761086
    Abstract: The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: September 1, 2020
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan
  • HIGH THROUGHPUT BH3 PROFILING: A RAPID AND SCALABLE TECHNOLOGY TO BH3 PROFILE ON LOW NUMBERS OF CELLS
    Publication number: 20180128813
    Abstract: The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.
    Type: Application
    Filed: April 27, 2016
    Publication date: May 10, 2018
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan
  • COMPOSITIONS AND METHODS FOR ASSESSING TOXICITY USING DYNAMIC BH3 PROFILING
    Publication number: 20180120297
    Abstract: The present invention provides methods of assessing toxicity using Dynamic BH3 profiling.
    Type: Application
    Filed: April 27, 2016
    Publication date: May 3, 2018
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Anthony Letai, Patrick Bhola, Jeremy Ryan