Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: A method is implemented at an electronic device for displaying output from an application. The electronic device includes a display module and an application. The application sends to the display module a request to display output on the fixed orientation display. The display module determines whether the application is able to scale the output from the application to fit the fixed orientation display. In accordance with a determination that the application is able to scale the output, the electronic device causes the application to receive information concerning the fixed orientation display from the display module and scale the output for display on the fixed orientation display according to the information. In accordance with a determination that the application is not able to scale the output, the display module scales the output received from the application, thereby enabling the output of the application to be displayed on the fixed orientation display.

Abstract: An assembly for pressure testing of components, such as a valve of an HVAC system. The assembly includes a hand truck, a tank and a housing mounted on the base of the hand truck. A control unit is encased within the housing and coupled to a solenoid, wherein the solenoid is coupled to a valve. The valve connects a pressure regulator of the tank to the component. The control unit can receive instruction from an external device at a safe distance from the assembly, and upon receiving the instruction, the control unit can actuate the solenoid to open the valve.

Abstract: Various embodiments of a leveling device are disclosed having a number of innovative features. The leveling device can have a top surface that is upwardly inclined in a lengthwise direction. The top surface can include ridges extending upward to define one or more bounded sections or regions sized to receive and hold a leg or foot of an article that needs to be leveled or stabilized. For example, the leveling device can be placed under the leg of a grill to level the grill surface.

Abstract: The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.

Abstract: Compositions and methods for the treatment of bacterial infections include conjugates containing an Fc domain covalently linked to one or more monomers of cyclic heptapeptides or one or more dimers of cyclic heptapeptides. In particular, conjugates can be used in the treatment of bacterial infections caused by Gram-negative bacteria.

Abstract: A rim assembly for a bicycle wheel includes a rim, a first protruding tire retaining feature attached to a first surface of the rim, and a second protruding tire retaining feature attached to a second surface of the rim. The first surface is a surface of a first tire retaining wall of a radially outer tire engaging portion of the rim, and the second surface is a surface of a second tire retaining wall of the radially outer tire engaging portion. The second surface faces the first surface. The first protruding tire retaining feature and the second protruding tire retaining feature are made of a first material, and the first tire retaining wall and the second tire retaining wall are made of a second material. The second material is different than the first material.

Abstract: Forming features in the surface of a bicycle component involves depositing a substance onto a substrate in a geometric pattern to form a transfer medium. Forming features may also involve positioning the transfer medium relative to an unformed bicycle component, and forming a negative of the geometric pattern in the bicycle component through the application of heat and/or pressure to the transfer medium and the unformed bicycle component. The transfer medium may be configured for use in the molding of carbon fiber reinforced plastic (“CFRP”) bicycle components and may include a substrate formed of a flexible material, and a geometric pattern formed of a hard material, the hard material different than the flexible material.

Abstract: A firearm sling includes a shooting rest. The shooting rest may include a bifurcated cavity filled with deformable media. The bifurcated cavity defines a trough along at least a portion of a length of the shooting rest. The firearm sling may be coupled to a firearm to facilitate carrying the firearm over a shoulder or across a torso, the shooting rest providing padding for comfort in carrying the firearm as well as a support for the firearm to improve marksmanship.

Abstract: Forming features in the surface of a bicycle component involves depositing a substance onto a substrate in a geometric pattern to form a transfer medium. Forming features may also involve positioning the transfer medium relative to an unformed bicycle component, and forming a negative of the geometric pattern in the bicycle component through the application of heat and/or pressure to the transfer medium and the unformed bicycle component. The transfer medium may be configured for use in the molding of carbon fiber reinforced plastic (“CFRP”) bicycle components and may include a substrate formed of a flexible material, and a geometric pattern formed of a hard material, the hard material different than the flexible material.

Abstract: An assembly for pressure testing of components, such as a valve of an HVAC system. The assembly includes a hand truck, a tank and a housing mounted on the base of the hand truck. A control unit is encased within the housing and coupled to a solenoid, wherein the solenoid is coupled to a valve. The valve connects a pressure regulator of the tank to the component. The control unit can receive instruction from an external device at a safe distance from the assembly, and upon receiving the instruction, the control unit can actuate the solenoid to open the valve.

Abstract: A firearm sling includes a shooting rest. The shooting rest may include a bifurcated cavity filled with deformable media. The bifurcated cavity defines a trough along at least a portion of a length of the shooting rest. The firearm sling may be coupled to a firearm to facilitate carrying the firearm over a shoulder or across a torso, the shooting rest providing padding for comfort in carrying the firearm as well as a support for the firearm to improve marksmanship.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: A firearm sling includes a shooting rest. The shooting rest may include a bifurcated cavity filled with deformable media. The bifurcated cavity defines a trough along at least a portion of a length of the shooting rest. The firearm sling may be coupled to a firearm to facilitate carrying the firearm over a shoulder or across a torso, the shooting rest providing padding for comfort in carrying the firearm as well as a support for the firearm to improve marksmanship.

Abstract: A method is implemented at an electronic device for displaying output from an application. The electronic device includes a display module and an application. The application sends to the display module a request to display output on the fixed orientation display. The display module determines whether the application is able to scale the output from the application to fit the fixed orientation display. In accordance with a determination that the application is able to scale the output, the electronic device causes the application to receive information concerning the fixed orientation display from the display module and scale the output for display on the fixed orientation display according to the information. In accordance with a determination that the application is not able to scale the output, the display module scales the output received from the application, thereby enabling the output of the application to be displayed on the fixed orientation display.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: A method is implemented at an electronic device for displaying output from an application. The electronic device includes a display module and an application. The application sends to the display module a request to display output on the fixed orientation display. The display module determines whether the application is able to scale the output from the application to fit the fixed orientation display. In accordance with a determination that the application is able to scale the output, the electronic device causes the application to receive information concerning the fixed orientation display from the display module and scale the output for display on the fixed orientation display according to the information. In accordance with a determination that the application is not able to scale the output, the display module scales the output received from the application, thereby enabling the output of the application to be displayed on the fixed orientation display.

Abstract: A rim assembly for a bicycle wheel includes a rim, a first protruding tire retaining feature attached to a first surface of the rim, and a second protruding tire retaining feature attached to a second surface of the rim. The first surface is a surface of a first tire retaining wall of a radially outer tire engaging portion of the rim, and the second surface is a surface of a second tire retaining wall of the radially outer tire engaging portion. The second surface faces the first surface. The first protruding tire retaining feature and the second protruding tire retaining feature are made of a first material, and the first tire retaining wall and the second tire retaining wall are made of a second material. The second material is different than the first material.

Abstract: A method is implemented at an electronic device for displaying output from an application. The electronic device includes a display module and an application. The application sends to the display module a request to display output on the fixed orientation display. The display module determines whether the application is able to scale the output from the application to fit the fixed orientation display. In accordance with a determination that the application is able to scale the output, the electronic device causes the application to receive information concerning the fixed orientation display from the display module and scale the output for display on the fixed orientation display according to the information. In accordance with a determination that the application is not able to scale the output, the display module scales the output received from the application, thereby enabling the output of the application to be displayed on the fixed orientation display.