Abstract: A compression wrap and method for temperature-controlled application of pressure on an arm of a subject, comprising a fluid bladder comprising a first element comprising two or more first flaps; a second element comprising one or more digital flaps; and a third element comprising two or more second flaps, wherein the first element and the third element are connected along a first edge and the second element is connected to the first element and the third element along a second edge.

Abstract: A damper link associated with a sway bar system is disclosed. The damper link can include a damper chamber with a first fluid reservoir, a shaft configured to move in an out the damper chamber, and a piston. The damper link can further include a negative gas chamber housed in the damper chamber wherein a gas in the gas chamber is compressed or decompressed by a movement of the piston. The damper link can further include an additional reservoir with a positive gas chamber. The damper link can further include a hose fluidly connecting the negative gas chamber to the positive gas chamber to maintain a constant gas pressure between the negative gas chamber to the positive gas chamber.

Abstract: A damper link associated with a sway bar system is disclosed. The damper link can include a damper chamber with a first fluid reservoir, a shaft configured to move in an out the damper chamber, and a piston. The damper link can further include a negative gas chamber housed in the damper chamber wherein a gas in the gas chamber is compressed or decompressed by a movement of the piston. The damper link can further include an additional reservoir with a positive gas chamber. The damper link can further include a hose fluidly connecting the negative gas chamber to the positive gas chamber to maintain a constant gas pressure between the negative gas chamber to the positive gas chamber.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: Systems and methods for managing digital rewards for users associated with completion of product reviews by the users. According to certain aspects, a server determines that a user purchased a given product, and offers a digital reward to the user for completing a review of the given product. An electronic device enables the user to complete the review and communicates the review to a digital repository that avails the review for use by a website. The server interfaces with the digital repository to determine that the user completed the digital review, and applies the digital reward to an account of the user.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof.

Abstract: The invention provides modified heavy chain constant regions including a cysteine at position 295 by EU numbering and optionally at position 239 by EU numbering. These cysteine residues provide sites for conjugation to a drug or label. When both cysteines are present in a normal heterodimeric antibody format, there are four such sites per molecule of antibody allowing a stoichiometry of one molecule of antibody to four of drug or label. Selection of the cysteine at position 295 with or without cysteine at position 239 is advantageous over cysteines at many other positions due to ease of expression, stability and cytotoxicity.

Abstract: A compression wrap and method for temperature-controlled application of pressure on an arm of a subject, comprising a fluid bladder comprising a first element comprising two or more first flaps; a second element comprising one or more digital flaps; and a third element comprising two or more second flaps, wherein the first element and the third element are connected along a first edge and the second element is connected to the first element and the third element along a second edge.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof.

Abstract: The invention provides modified heavy chain constant regions including a cysteine at position 295 by EU numbering and optionally at position 239 by EU numbering. These cysteine residues provide sites for conjugation to a drug or label. When both cysteines are present in a normal heterodimeric antibody format, there are four such sites per molecule of antibody allowing a stoichiometry of one molecule of antibody to four of drug or label. Selection of the cysteine at position 295 with or without cysteine at position 239 is advantageous over cysteines at many other positions due to ease of expression, stability and cytotoxicity.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia. Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: An apparatus for developing goal scoring skills is disclosed herein. The apparatus includes a goal, and a three-dimensional structure. The three-dimensional structure is configured to replicate a human goalkeeper to improve a training experience for a user. The apparatus is useful for developing and improving goal scoring skills, and preferably, for developing and improving hockey goal scoring skills.

Abstract: The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to GPC3 and conjugates thereof.

Abstract: The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically hind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically hind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.

Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.

Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.