Abstract: Methods, systems, and devices are described for wireless communication. A first device, such as a user equipment (UE) may be configured with a peak data rate that corresponds to the radio frequency (RF) capacity of a modem and a sustained data rate that corresponds to the baseband capacity. The first device may receive a set of data blocks during a transmission burst from a second device. The quantity of data blocks in the burst may be based on the peak data rate. The first device may store time domain samples or frequency tones for the data and then power down the RF components for an interval based on how long it will take to process the data. The first device may then process the data at the sustained data rate. After the rest interval, the first device may power up the RF components and receive another burst of data.

Abstract: Various aspects of the present disclosure provide an apparatus for wireless communication. The apparatus may include an integrated circuit, an antenna, and a module located adjacent to the antenna. The module may include at least one of a power amplifier or a low-noise amplifier. The power amplifier may be configured to amplify a signal received from the integrated circuit for transmission by the antenna. The low-noise amplifier may be configured to amplify a signal received from the antenna for reception by the integrated circuit. The module may be separate from the integrated circuit. A length of a feed line connecting the antenna and the module may be less than a length of a feed line connecting the module and the integrated circuit. The module may also include a switching mechanism configured to switch operation of the module between transmission and reception.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: The present invention provides Lig-and-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.

Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of: wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.

Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.

Abstract: Various embodiments are disclosed for implementing joint non-linear interference cancellation (NLIC) in communication receivers with multiple receiver antennas to cancel or mitigate self-jamming interference from the same aggressor transmitter. A victim receiver may exploit the correlated nature of the interference signals received by the multiple receiver antennas to reduce the computational complexity of an NLIC scheme and improve performance. The victim receiver may select an Rx antenna/Rx chain that experiences the strongest interference from the aggressor transmitter and may perform a full NLIC operation using Tx data from the aggressor transmitter to estimate the strongest interference signal. The NLIC operation may estimate each remaining interference signal by applying a complex coefficient from a single-tap adaptive filter to the estimate of the strongest interference signal.

Abstract: A compound with the formula (I), wherein: R2 is of formula (II), where X is selected from the group comprising: OH, SH, CO2H, COH, N?C?O, NHNH2, CONHNH2, formula (A), formula (B), NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl; RC1, RC2 and RC3 are independently selected from H and unsubstituted C1-2 alkyl; and either: R12 is selected from the group consisting of: (ia) C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene; (ib) C1-5 saturated aliphatic alkyl; (ic) C3-6 saturated cycloalkyl; (id) formula (C), wherein each of R21, R22 and R23 are independently selected from H, C1-3 saturated alkyl, C2-3 alkenyl, C2-3 alkynyl and cyclopropyl, where the total number of carbon atoms in the R12 group is no more than 5; (ie) formula (D), wherein one of R25a and R25b is H and the other is selected from: phenyl, which phenyl is optionally substituted by a group

Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.

Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.

Abstract: Some aspects of the present disclosure provide for methods, apparatus, and computer software for low-power synchronization of wireless communication devices. In one example, an asynchronous code division multiple access (CDMA) channel may be utilized for uplink communication. By utilizing asynchronous CDMA on the uplink, synchronization requirements are relaxed relative to other forms of communication. Accordingly, a synchronization period after coming out of a sleep state can be short, reducing power consumption during re-synchronization. In another example, a low-power companion receiver, rather than the full-power WWAN receiver, may be utilized to acquire a sync signal while the device is in its sleep state. Once synchronism is achieved via the low-power companion receiver, the full-power radio may power up and perform communication with the network. By shifting the synchronization from the full-power radio to the low-power companion radio, power consumption during re-synchronization can be achieved.

Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.

Abstract: Certain aspects of the present disclosure relate to techniques and apparatus for efficient support of connected discontinuous reception (C-DRX) by using a wireless device (e.g., a user equipment (UE)) with a second receiver. A wireless device with two receivers may place one receiver in a low power mode and take the receiver out of the low power mode in response to a signal received from a serving base station (BS) of the wireless device. A BS may direct a wireless device to enter a low power DRX (LP-DRX) mode or enhanced DRX mode having longer low power cycles than a non-enhanced DRX mode, and the wireless device may place a primary receiver in a low power mode in response to the directive from the BS. Other aspects, embodiments, and features are also claimed and disclosed.

Abstract: Systems, methods, apparatuses, and computer-program products for performing dynamic bandwidth switching between control signals and data signals of differing bandwidths are disclosed. Frame formats are disclosed in which control signals are transmitted at different bandwidths than data signals. Receiver architectures for receiving the signaling formats are disclosed. A receiver can receive a relatively narrowband control signal while consuming a relatively low power and then dynamically adjust characteristics of various components to receive a data signal at a higher bandwidth while consuming a relatively higher power.

Abstract: Methods, systems, and devices are described for wireless communication. A first device, such as a user equipment (UE) may be configured with a peak data rate that corresponds to the radio frequency (RF) capacity of a modem and a sustained data rate that corresponds to the baseband capacity. The first device may receive a set of data blocks during a transmission burst from a second device. The quantity of data blocks in the burst may be based on the peak data rate. The first device may store time domain samples or frequency tones for the data and then power down the RF components for an interval based on how long it will take to process the data. The first device may then process the data at the sustained data rate. After the rest interval, the first device may power up the RF components and receive another burst of data.

Abstract: A wireless device is described. The wireless device includes an antenna. The wireless device also includes a hybrid transformer. The wireless device further includes a frequency matching termination port. The frequency matching termination port provides impedance matching with the antenna at multiple frequencies. The frequency matching termination port may include multiple resistors, inductors and capacitors that can be switched in/out.

Abstract: Exemplary embodiments are directed to systems, devices, and methods for mitigating effects of transmit signal leakage. A transceiver may include a transmitter and a receiver. The transceiver may further include a multi-tap analog adaptive filter coupled to each of the transmitter and the receiver and configured to generate an estimated transmit leakage signal based on at least a portion of a transmit signal from the transmitter and an error signal from the receiver.

Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.

Abstract: Methods, systems, and devices are described for reducing interference for wireless communication in a wireless device with multiple receive antennas. In aspects for reducing interference, a combined signal may be generated by combining a plurality of received signals from a plurality of respective receive antennas of the wireless device, for example, using one or more different types of combining A common distortion of the plurality of received signals may be estimated based at least in part on the combined signal, and interference reduction may be performed on one or more of the plurality of received signals based at least in part on the estimated common distortion.

Abstract: Systems, methods, apparatuses, and computer-readable storage media for managing power consumption of a mobile device are disclosed. The systems, method, apparatus, and computer-readable storage medium may cause the base station to identify an energy metric associated with a mobile device, and to configure the transmission between the base station and the mobile device based at least in part on the energy metric. The configuration of the transmission may reduce the power consumption of the mobile device for processing the transmission.