Patents by Inventor Patrick C. Kung

Patrick C. Kung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibody to a human thymocyte antigen
    Patent number: 4806629
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 70% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapuetic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: February 21, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to human cytotoxic and suppressor T cells, antibody, and methods
    Patent number: 4803262
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human cytotoxic and suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: February 7, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Compositions and methods using a monoclonal antibody to a human T cell antigen
    Patent number: 4798806
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 1, 1986
    Date of Patent: January 17, 1989
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to antigen on human thymocytes
    Patent number: 4784951
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: November 15, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to a human T cell antigen, antibody, and methods
    Patent number: 4743681
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 29, 1984
    Date of Patent: May 10, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing complement-fixing monoclonal antibody to human suppressor T cells, antibody and methods
    Patent number: 4725543
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: February 16, 1988
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human suppressor T cells
    Patent number: 4709015
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: November 24, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigen, antibody, and methods
    Patent number: 4691010
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 9, 1984
    Date of Patent: September 1, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human T cells
    Patent number: 4680383
    Abstract: Hybrid cell line for producing of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: July 14, 1987
    Assignee: Ortho Pharmaceutical
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Immunoassay for biologically active human interferon-gamma employing unique monoclonal antibodies
    Patent number: 4666865
    Abstract: Rapid, sensitive and accurate immunoassays for biologically active natural or recombinant human interferon-gamma (huIFN-gamma) based upon monoclonal antibodies which react specifically with epitopes of the biologically active form of huIFN-gamma are disclosed. The immunoassays include sandwich immunoradiometric assay of the forward, reverse or simultaneous type and competitive binding assay such as radioimmunoassay. The assays are also useful for the detection of macrophage activation factor now believed to be identical to huIFN-gamma. In addition, methods of purification of huIFN-gamma employing the monoclonal antibodies are described.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: May 19, 1987
    Assignee: Centocor, Inc.
    Inventors: Tse W. Chang, Patrick C. Kung, Junming Le, Victor Liu, Jan Vilcek
  • Methods and compositions using monoclonal antibody to human T cells
    Patent number: 4657760
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Monoclonal antibody to human helper T cells
    Patent number: 4658020
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Complement-fixing monoclonal antibody to human T cells
    Patent number: 4658019
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 10, 1984
    Date of Patent: April 14, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Methods and compositions using complement fixing monoclonal antibody to human T cells
    Patent number: 4654210
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: March 31, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Methods and compositions using monoclonal antibody to human helper T cells
    Patent number: 4652447
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: March 24, 1987
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to a human early thymocyte antigens, antibody, and methods
    Patent number: 4624925
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: November 25, 1986
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to a human T cell antigen, antibody, and methods
    Patent number: 4614720
    Abstract: Hybrid cell line for production of monocloral antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: September 30, 1986
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to human helper T cells
    Patent number: 4515895
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: May 7, 1985
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing monoclonal antibody to human T cells
    Patent number: 4515894
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: May 7, 1985
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
    Patent number: 4515893
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells and cutaneous T lymphoma cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: May 7, 1985
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein