Abstract: The invention relates to an inhibitor of FXYD2 wherein said inhibitor reduces the expression and/or activity of FXYD2 in a subject in need thereof and targets at least the region comprising or consisting of the nucleotides 219-229 of SEQ ID NO: 3. Inventors have shown that targeting a region of FXYD2 can be used to inhibit and/or reduce the expression and/or activity of FXYD2. They have designed and synthesized an antisense oligonucleotide (SEQ ID NO: 4) targeting the rat and human FXYD2 gene. The have performed intrathecal injection of FXYD2 optimized ASO in two rat models of pain (neuropathic and inflammatory pain). They have shown that FXYD2 ASO efficiently reduces its expression in rat Dorsal root ganglion (DRG). The have demonstrated that FXYD2 ASO dramatically reduces neuropathic pain in the Spinal Nerve Ligation (SNL) rat model and analgesic effect of FXYD2 ASO on neuropathic pain is greater than that of Ziconotide, the current market leader.

Abstract: A composition configured to create a superhydrophobic surface includes a fluorinated hydrophobic component dispersible in an aqueous dispersion; cellulosic elements of a size ranging from 100 nm to 100 ?m; and water. The hydrophobic component is selected from the group consisting of fluorinated polymers, perfluorinated polymers, and mixtures thereof; and the cellulosic elements are micro- and nano-fibrillated cellulose. A disposable absorbent article includes a substrate having a surface, the surface including a composition including a fluorinated hydrophobic component dispersible in an aqueous dispersion; cellulosic elements of a size ranging from 100 nm to 100 ?m; and water, wherein the surface exhibits a contact angle greater than 150 degrees.

Abstract: A superhydrophobic surface includes a substrate treated with a composition including a hydrophobic matrix component free of fluorine; filler particles, wherein the filler particles are plant-based elements of a size ranging from 100 nm to 100 ?m; and water, wherein the hydrophobic component is in an aqueous dispersion, and wherein the surface exhibits a water contact angle of 150° or greater. Also, a disposable absorbent article includes a substrate having a surface, the surface including a composition including a hydrophobic matrix component free of fluorine; filler particles, wherein the filler particles are plant-based elements of a size ranging from 100 nm to 100 ?m, wherein the plant-based elements include micro- and nano-fibrillated cellulose; and water, wherein the hydrophobic component is in an aqueous dispersion, and wherein the surface exhibits a water contact angle of 150° or greater.

Abstract: A non-fluorinated composition configured to create a superhydrophobic surface includes a hydrophobic matrix component free of fluorine; filler particles, wherein the filler particles are plant-based elements of a size ranging from 100 nm to 100 ?m; and water, wherein the hydrophobic matrix component is in an aqueous dispersion. Also, a non-fluorinated composition configured to create a superhydrophobic surface includes a hydrophobic matrix component free of fluorine, wherein the hydrophobic matrix component includes a polyolefin, a natural wax, or a synthetic wax; filler particles, wherein the filler particles are plant-based elements of a size ranging from 100 nm to 100 ?m; an emulsifier; and water, wherein the hydrophobic component is in an aqueous dispersion.

Abstract: A fuel cell system is disclosed, which includes an anode recirculation loop including a fuel cell stack for generating power, a fuel supply device for providing a fuel to the anode recirculation loop, an air supply device for providing air to a cathode of the fuel cell stack, a voltage monitoring device for monitoring a voltage of the fuel cell stack, and an anode protection controller. The anode protection controller decreases a current drawn from the fuel cell stack by a predetermined amount whenever the voltage of the fuel cell stack drops below a predetermined voltage threshold and decreases a fuel flowrate provided to the anode recirculation loop based on the decreased current, so as to maintain a steam to carbon ratio in the anode recirculation loop above a predetermined steam to carbon ratio limit. A shutdown method for the fuel cell system are also disclosed.

Abstract: A composition configured to create a superhydrophobic surface includes a fluorinated hydrophobic component dispersible in an aqueous dispersion; cellulosic elements of a size ranging from 100 nm to 100 ?m; and water. The hydrophobic component is selected from the group consisting of fluorinated polymers, perfluorinated polymers, and mixtures thereof; and the cellulosic elements are micro- and nano-fibrillated cellulose. A disposable absorbent article includes a substrate having a surface, the surface including a composition including a fluorinated hydrophobic component dispersible in an aqueous dispersion; cellulosic elements of a size ranging from 100 nm to 100 ?m; and water, wherein the surface exhibits a contact angle greater than 150 degrees.

Abstract: A fuel cell system is disclosed, which includes an anode recirculation loop including a fuel cell stack for generating power, a fuel supply device for providing a fuel to the anode recirculation loop, an air supply device for providing air to a cathode of the fuel cell stack, a voltage monitoring device for monitoring a voltage of the fuel cell stack, and an anode protection controller. The anode protection controller decreases a current drawn from the fuel cell stack by a predetermined amount whenever the voltage of the fuel cell stack drops below a predetermined voltage threshold and decreases a fuel flowrate provided to the anode recirculation loop based on the decreased current, so as to maintain a steam to carbon ratio in the anode recirculation loop above a predetermined steam to carbon ratio limit. A shutdown method for the fuel cell system are also disclosed.

Abstract: The present invention relates to an inhibitor of FXYD2 gene expression for use in a method for treating neuropathic pain in a patient in need thereof. The invention also relates to a pharmaceutical composition comprising an inhibitor of FXYD2 gene expression, wherein said pharmaceutical composition is formulated for a direct administration into the peripheral nervous system (PNS) of a patient (e.g., formulated for intrathecal administration).

Abstract: A method for power management for a retrofit sensor system for a vehicle, the retrofit sensor system including a sensor module that includes a sensor, an energy storage module, an energy harvester, and a wireless communication module. The method includes: determining a driving state predictive of a driving event; operating the sensor module in a mid-power mode; receiving a trigger; operating the sensor module in a high-power mode; wirelessly transmitting data at the sensor module; and operating the sensor module in a low-power mode.

Abstract: The present invention relates to an inhibitor of FXYD2 gene expression for use in a method for treating neuropathic pain in a patient in need thereof. The invention also relates to a pharmaceutical composition comprising an inhibitor of FXYD2 gene expression, wherein said pharmaceutical composition is formulated for a direct administration into the peripheral nervous system (PNS) of a patient (e.g., formulated for intrathecal administration).

Abstract: A method for power management for a retrofit sensor system for a vehicle, the retrofit sensor system including a sensor module that includes a sensor, an energy storage module, an energy harvester, and a wireless communication module. The method includes: determining a driving state predictive of a driving event; operating the sensor module in a mid-power mode; receiving a trigger; operating the sensor module in a high-power mode; wirelessly transmitting data at the sensor module; and operating the sensor module in a low-power mode.

Abstract: A method for power management for a retrofit sensor system for a vehicle, the retrofit sensor system including a sensor module that includes a sensor, an energy storage module, an energy harvester, and a wireless communication module. The method includes: determining a driving state predictive of a driving event; operating the sensor module in a mid-power mode; receiving a trigger; operating the sensor module in a high-power mode; wirelessly transmitting data at the sensor module; and operating the sensor module in a low-power mode.

Abstract: A vehicle retrofit system for a vehicle having a license plate, the vehicle retrofit system including a sensor module with: a casing, a set of sensors, a communication system, a power system, and a sensor module retention mechanism.

Abstract: There is disclosed a method for detecting potentially fraudulent activity in a remote financial transaction system. The system comprises a client computing device configured for data communication with a financial services server via a data communications network. The client computing device is further configured to display a web page for receiving transaction information from a user and to communicate the received transaction information to the financial services server via the data communications network in order to effect the financial transaction. The method comprises, when transaction information is communicated to the financial services server by the client computing device, the client computing device additionally communicating meta data relating to the configuration of the web page to a configuration data server via the data communications network. The method further comprises the configuration data server comparing the received meta data to a stored template of meta data for the web page.

Abstract: A method of authenticating a transaction comprises receiving from a user's mobile device user location information and associated network data in response to a change of location or network of the mobile device, storing the location information and (optionally) the network data in a database in a record associated with the user, receiving a request for authentication of a transaction purportedly by the user, the request including transaction location information, comparing the transaction location information and (optionally) the network data to the stored user location information associated with the user, and generating authentication data in response to the result of the comparison.

Abstract: A method of connecting a user computing device to a wireless network comprises establishing a wireless connection between the user computing device and a first wireless network. The user provides identifying information to a server via the first wireless network. In response to the server authenticating the user and upon successful authorisation of the user having the appropriate rights, the user receives access information for a second wireless network from the server. The user computing device establishes a wireless connection to the second wireless network using the received access information. The method has the advantage that the first wireless network can be easily discoverable, whereas the second wireless network can have an enhanced level of security.

Abstract: An authentication system is disclosed. The system comprises means for receiving an authentication request associated with the transaction wherein the request comprises data identifying a communication device associated with a user authorised to perform the transaction; means for sending a Mobile Application Part, MAP, protocol request message in response to the authentication request; means for receiving, in response to the MAP protocol request, data indicative of whether a communication sent to the communication device will be forwarded to a different communication device. The received data indicative of whether a communication sent to the communication device will be forwarded to a different communication device is used in determining whether to authenticate the transaction.

Abstract: An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing.

Abstract: An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing.

Abstract: An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test strip includes fluid volume control dams to prevent spillage of the fluid from the strip and a chemical reagent solution that facilitates end-point testing.