Abstract: A method for producing Actinium-225 from proton spallation of thorium targets via a radium generator. The method includes dissolving a thorium target into a thorium solution, evaporating the thorium solution thereby resulting in a dried thorium salt, reconstituting the dried thorium salt in sulfuric acid for formation of neutral thorium species, passing neutral thorium species through a cation exchange chromatography column for bulk thorium removal, conducting extraction chromatography in a mixed resin bed thereby eluting radium, evaporating the radium containing eluent, reconstituting dried radium, and conducting extraction chromatography to elute a purified radium fraction thereby constructing a radium generator.