Abstract: Systems and methods herein describe a navigation system for reducing complex maneuvers in navigation instructions. The navigation system receives a transportation request comprising an origin and a destination, determines a first shortest path from the origin to the destination location, and identifies a subset of maneuvers in the first shortest path that are associated with a penalty value. The navigation system further generates a modified path value by applying the penalty value to the identified subset of maneuvers, and in response to identifying that the modified total path value exceeds a threshold value, determines a second shortest path from the origin to the destination. The navigation system generates navigation instructions comprising a second plurality of maneuvers associated with the second shortest path, and transmits the navigation instructions to a computing device.

Abstract: Novel compounds comprising x-conjugated moicties are disclosed, as well as their uses as semiconducting materials. The novel compounds comprise adjacent x-electron rich and x-electron deficient moieties. The novel compounds exhibit improved charge mobility and are particularly suited to use in electronic devices and components, such as organic thin film transistors.

Abstract: Multicast/Broadcast Service (MBS) for user equipments (UE) in Radio Resource Control (RRC) idle/inactive modes via signally of MBS frequency ranges and/or switching between frequency ranges as required. Bandwidth Part (BWP) operation for MBS in RRC_IDLE and RRC_INACTIVE states may be implemented using a dedicated MBS BWP or by sharing a frequency range with other operations. An MBS frequency range may be wider or narrower than an initial BWP used by a UE, for example. MBS frequency range configure may be achieved in a number of ways, such as via Control Resource Set (CORESET), search space, and/or PDCCH monitoring occasions pattern settings for MBS in RRC idle/inactive. Downlink scheduling without dynamic grant for MBS in RRC idle/inactive may include configured scheduling and/or semi-persistent scheduling. Downlink repetition for MBS in RRC idle/inactive may include PDSCH repetition and/or PDCCH repetition.

Abstract: Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

Abstract: Disclosed herein is a head fixture for adhesively bonding a part of a golf club head to a body of the golf club head. The head fixture includes a bottom portion, including a body retainer, and a top portion, selectively attachable to the bottom portion and including pressure applicators spaced apart about the top portion. Each one of the pressure applicators comprises a ratcheting mechanism and a ribbed shaft engaged with the ratcheting mechanism such that, when the top portion is selectively attached to the bottom portion, the ribbed shaft is movable away from the body retainer into a position, associated with a pressure applied to the part of the golf club head by the ribbed shaft, and the ribbed shaft is non-movably fixable, relative to the body retainer, in the position.

Abstract: An extraction device can include a delivery shaft having a lumen and a distal end, a first wire forming a first arc and being positionable distal to the distal end of the delivery shaft while ends of the first arc are at a distalmost end of the delivery shaft, and a second wire forming a second arc and being positionable distal to the distal end of the delivery shaft while ends of the second arc are at the distalmost end of the delivery shaft. A distalmost extent of the first wire is distal to a distalmost extent of the second wire. The first wire and the second wire are separately retractable relative to the delivery shaft.

Abstract: Systems and methods for controlling chlorinators for pools and spas are provided. A controller communicates with a processor positioned within a replaceable cell cartridge of a chlorinator, to allow for remote control and diagnosis of the chlorinator and/or cell cartridge. The cell cartridge stores, in non-volatile memory on board the cartridge, one or more parameters associated with the cartridge. The controller can obtain this information from the processor of the cell cartridge, and can use same to configure operation of the chlorinator. Information relating to remaining cell life can be updated by the controller and stored in the non-volatile memory of the cell cartridge. Electrical and software-based mechanisms are provided for ensuring operation of only compatible cell cartridges with the chlorinator. A system for remotely diagnosing errors associated with the chlorinator is also provided.

Abstract: An apparatus for treating spasticity can include a splint configured to receive a patient wrist and hand including a wrist portion of the splint including a moveable closure configured to secure a wrist of the patient to the splint. A hand portion of the splint can be rigidly coupled to the wrist portion, wherein the hand portion can include a hand portion that is shaped to receive a palm of the patient's hand and an inflatable bladder can be coupled to the hand portion, wherein the inflatable bladder can be configured to expand against fingers of the patient's hand during inflation.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: Systems and methods for controlling chlorinators for pools and spas are provided. A controller communicates with a processor positioned within a replaceable cell cartridge of a chlorinator, to allow for remote control and diagnosis of the chlorinator and/or cell cartridge. The cell cartridge stores, in non-volatile memory on board the cartridge, one or more parameters associated with the cartridge. The controller can obtain this information from the processor of the cell cartridge, and can use same to configure operation of the chlorinator. Information relating to remaining cell life can be updated by the controller and stored in the non-volatile memory of the cell cartridge. Electrical and software-based mechanisms are provided for ensuring operation of only compatible cell cartridges with the chlorinator. A system for remotely diagnosing errors associated with the chlorinator is also provided.

Abstract: An extraction device can include a delivery shaft having a lumen and a distal end, a first wire forming a first arc and being positionable distal to the distal end of the delivery shaft while ends of the first arc are at a distalmost end of the delivery shaft, and a second wire forming a second arc and being positionable distal to the distal end of the delivery shaft while ends of the second arc are at the distalmost end of the delivery shaft. A distalmost extent of the first wire is distal to a distalmost extent of the second wire. The first wire and the second wire are separately retractable relative to the delivery shaft.

Abstract: Apparatus and methods for cataract extraction are disclosed. An extraction device may include a delivery shaft having a lumen and a distal end. The lumen may include a first channel and a second channel diverging at the distal end. A wire may form a loop and extend from the first channel and the second channel. The wire may be movable within the lumen.

Abstract: A chlorinator system for pools or spas is disclosed. The chlorinator system includes a replaceable chlorinator cell cartridge having built in sensors, switches, and custom connections. The chlorinator system includes a controller, a chlorinator, a replaceable cell cartridge, and compression fittings for connecting the chlorinator to piping of a pool or spa system. The cartridge includes a body, a bi-directional flow switch, a connector plug, a lid, a printed circuit board, which includes non-volatile memory, and electrically-charged plates or blades.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: An intraocular drainage device may include a monolithic silicone body having a flap, a rigid bottom plate having a portion configured to contact a corresponding portion of the flap, and a tube having a proximal end disposed between the flap and the rigid bottom plate. The corresponding portion of the flap may be configured to separate from the portion of the rigid bottom plate responsive to a fluid pressure in aqueous humor received from the tube. A plurality of parallel microgrooves may be formed on one or more portions of one or more outer surfaces of the intraocular drainage device.

Abstract: A chlorinator system for pools or spas is disclosed. The chlorinator system includes a replaceable chlorinator cell cartridge having built in sensors, switches, and custom connections. The chlorinator system includes a controller, a chlorinator, a replaceable cell cartridge, and compression fittings for connecting the chlorinator to piping of a pool or spa system. The cartridge includes a body, a bi-directional flow switch, a connector plug, a lid, a printed circuit board, which includes non-volatile memory, and electrically-charged plates or blades.