Abstract: The compound 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid, or a pharmaceutically acceptable salt thereof, for use in the treatment of metastatic or advanced breast cancer at a dose of 150 to 600 mg per day.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: The compound 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid, or a pharmaceutically acceptable salt thereof, for use in the treatment of metastatic or advanced breast cancer at a dose of 150 to 600 mg per day.

Abstract: In some embodiments of the invention, the central controller may comprise a processor and a computer readable medium coupled to the processor. The computer readable medium comprises code, executable by the processor to implement a method. The method comprises identifying, by the processor, a sample container or a sample container holder associated with the sample container, and then accessing, by the processor, a location database storing mapping data correlating sample containers or sample container holders with sample containers to test regions in the storage unit. The test regions store sample containers with samples that have been or are to be tested according to different tests. After accessing the database, the method continues by providing, by the processor, a proposal for storage of the sample container or the sample container holder associated with the sample container in the storage unit.

Abstract: The invention provides an improved cannula assembly comprising a first cannula having a first length and first inner diameter, the first cannula having at least a flexible distal portion; a trochar having a second length and second diameter, the trochar having a sharp distal position capable of puncturing through skin and one or more blood vessels of a patient and sized such that the trochar may be inserted within the first cannula and extend beyond the flexible distal portion thereof; and at least one flexible second cannula for insertion in the first cannula, each second flexible cannula sized to extend beyond the distal portion of the first cannula for a predetermined length.

Abstract: In some embodiments of the invention, the central controller may comprise a processor and a computer readable medium coupled to the processor. The computer readable medium comprises code, executable by the processor to implement a method. The method comprises identifying, by the processor, a sample container or a sample container holder associated with the sample container, and then accessing, by the processor, a location database storing mapping data correlating sample containers or sample container holders with sample containers to test regions in the storage unit. The test regions store sample containers with samples that have been or are to be tested according to different tests. After accessing the database, the method continues by providing, by the processor, a proposal for storage of the sample container or the sample container holder associated with the sample container in the storage unit.

Abstract: System comprising (1) at least one rolling assembly formed by a rim, a tire and a tire tread support ring, designed to support the tire's load in the event of a substantial pressure loss; and (2) an electronic device for controlling the dynamic behavior of a vehicle equipped with the rolling assembly, wherein the ratio l/L between the respective axial widths l of the support ring and L of the tire tread is smaller than or equal to 0.30.

Abstract: An automatic device for dispensing samples in liquid medium for use in chemical or biological reactions, including a first supply plate with N receptacles, a second supply plate with M receptacles, a removable plate for sample and a piezoelectric micropipette.

Abstract: A device for centrifuging various samples of a product or a mixture of products which are chemical or biological, the device including a vessel which is open at the top and contains a vertical central shaft driven in rotation by a rotary driving means, a horizontal plate mounted interlocked in rotation on the central shaft and provided on its surface with a plurality of through orifices for the mounting of tubes which are each intended to contain a volume of a sample to be centrifuged, these through orifices having a substantially elongate shape with front and rear walls inclined at an acute angle of less than 90 degrees relative to the horizontal, and means for indexing the position of the plate each time the plate stops, in order to position through orifices of the tubes at predetermined sites.

Abstract: Aqueous composition intended to form an antimigration and antiozone protective coating on the external surface of a tire, comprising an aqueous emulsion of at least:(a) a polymer called constituent I, said constituent I being a homopolymer or copolymer based on at least one monomer chosen from the group of acrylic, methacrylic and vinyl esters and having a glass transition temperature below 0.degree. C.; and(b) a constituent II chosen from the group consisting of a hydrophilic silica and a homopolymer or copolymer based on at least one monomer chosen from the group of acrylic, methacrylic and vinyl monomers, said homopolymer or copolymer having a glass transition temperature above 25.degree. C.

Abstract: Aqueous composition intended to form an antimigration and antiozone protective coating on the external surface of a tire, comprising an aqueous emulsion of at least: (a) a polymer called constituent I, said constituent I being a homopolymer or copolymer based on at least one monomer chosen from the group of acrylic, methacrylic and vinyl esters and having a glass transition temperature below 0.degree. C.; and (b) a constituent II chosen from the group consisting of a hydrophilic silica and a homopolymer or copolymer based on at least one monomer chosen from the group of acrylic, methacrylic and vinyl monomers, said homopolymer or copolymer having a glass transition temperature above 25.degree. C.