Abstract: Methodology for demonstrating an effect of impairment during driving includes a set of eyewear devices configured to simulate predefined types of cognitive impairment and an activity set structured to provide depictions of roads for driving and associated pre-determined road conditions, the encountering and/or violating of which triggers a real-time feedback provided to the user participating in a driving exercise. The activity set includes a sensor mat underlying the mat with a depiction of roads and equipped with an array of tags activated in cooperation with the sensor scanner that is repositioned by the user along the roads while simulating the driving to provide such feedback. The choice of the exercise (and the corresponding eyewear device) is accompanied by establishing one-to-one correspondence between a particular depiction of roads and a corresponding set of tags of the array via tuning the sensor scanner to recognize only tags from such set of tags.

Abstract: A method of controlling a well comprising adding a scaling solution into a reservoir via the well which forms scale in pores or channels of the reservoir in order to inhibit fluid flow; then, deploying a fluid into the well to create a hydrostatic head extending for at least 50 m. In this way two independent barriers are provided to control the well. Intervention work may then be done on the well, involving removing the wellhead. Equipment can be deployed through the hydrostatic head without the requirement to set a plug.

Abstract: Methodology for demonstrating an effect of impairment during driving includes a set of eyewear devices configured to simulate predefined types of cognitive impairment and an activity set structured to provide depictions of roads for driving and associated pre-determined road conditions, the encountering and/or violating of which triggers a real-time feedback provided to the user participating in a driving exercise. The activity set includes a sensor mat underlying the mat with a depiction of roads and equipped with an array of tags activated in cooperation with the sensor scanner that is repositioned by the user along the roads while simulating the driving to provide such feedback. The choice of the exercise (and the corresponding eyewear device) is accompanied by establishing one-to-one correspondence between a particular depiction of roads and a corresponding set of tags of the array via tuning the sensor scanner to recognize only tags from such set of tags.

Abstract: The present invention relates to compositions and methods for enhancing the gene silencing activity of oligonucleotide compounds. In particular, the invention relates to inhibiting the expression or activity of suppressor proteins, such as RAB18, ZW10, STX18, SCFD2, NAPG, SAMD4B, or VPS37A, to increase the efficacy of ligand-conjugated oligonucleotide compounds in reducing the expression of target genes in a cell.

Abstract: A method of insulating an object, such as a pipe for carrying crude oil or natural gas, includes providing an insulating fluid comprising a base fluid and a viscosifying agent, wherein the viscosifying agent comprises silicon dioxide. The base fluid is optionally a non-aqueous base fluid. The method further includes the steps of adding the insulating fluid to a container, and placing the object in the container. The object which is insulated can be located remotely or subsea.

Abstract: The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.

Abstract: An apparatus (10) for lifting and moving an object that is underwater. The apparatus including a first (12) and a second (14) chamber, both chambers containing a first (16) and a second (18) fluid. There is a conduit (20, 21) in fluid communication with the first and second chambers, the first and second fluids moveable between the first and second chambers.

Abstract: An adhesive formulation is provided that is a waterborne bonding adhesive for adhering sheet membranes that may incorporate a solid plasticizer. The formulation is fast-curing and develops bond strength rapidly after application to a substrate as the adhesive dries, when the sheet membrane is mated to the substrate. The fast-curing characteristic is important to ensure the membrane is not displaced from the surface in windy exterior applications. The adhesive is formulated to form the bond between sheet membranes to substrates that illustratively include, steel, wood, concrete, roof boards, insulation, and fiberglass mat roof boards.

Abstract: An imaging system for an optical element, the imaging system comprising means for illuminating a targeted optical element with at least one incident light beam and means for directing at least two light beams returning from at least one surface of the illuminated optical element onto a detector; the detector adapted to measure relative light characteristics of the at least two returning light beams and to calculate at least one parameter of the optical element using the measured characteristics of the at least two returning light beams.

Abstract: This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be used in assays to identify conditions that modulate activity of the biological response.

Abstract: Systems and methods for operating an engine that may be frequently stopped and restarted are described. In one example, an engine is rotated in small crankshaft angle increments and stopped after the engine is rotated through a predetermined actual total number of crankshaft degrees so that the engine position does not change when the engine reaches a desired position.

Abstract: Systems and methods for operating an engine that may be frequently stopped and restarted are described. In one example, an engine is rotated in small crankshaft angle increments and stopped after the engine is rotated through a predetermined actual total number of crankshaft degrees so that the engine position does not change when the engine reaches a desired position.

Abstract: An adhesive formulation is provided that is a waterborne bonding adhesive for adhering sheet membranes that may incorporate a solid plasticizer. The formulation is fast-curing and develops bond strength rapidly after application to a substrate as the adhesive dries, when the sheet membrane is mated to the substrate. The fast-curing characteristic is important to ensure the membrane is not displaced from the surface in windy exterior applications. The adhesive is formulated to form the bond between sheet membranes to substrates that illustratively include, steel, wood, concrete, roof boards, insulation, and fiberglass mat roof boards.

Abstract: An apparatus (10) for lifting and moving an object that is underwater. The apparatus including a first (12) and a second (14) chamber, both chambers containing a first (16) and a second (18) fluid. There is a conduit (20, 21) in fluid communication with the first and second chambers, the first and second fluids moveable between the first and second chambers.

Abstract: An imaging system for an optical element, the imaging system comprising means for illuminating a targeted optical element with at least one incident light beam and means for directing at least two light beams returning from at least one surface of the illuminated optical element onto a detector; the detector adapted to measure relative light characteristics of the at least two returning light beams and to calculate at least one parameter of the optical element using the measured characteristics of the at least two returning light beams.

Abstract: This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be used in assays to identify conditions that modulate activity of the biological response.

Abstract: This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be used in assays to identify conditions that modulate activity of the biological response.