Abstract: A clot removal system for removing a clot from a body vessel, the clot removal system including: a microcatheter including: a distal segment comprising a first diameter; and a proximal segment comprising a second diameter; a stentriever positionable substantially within a lumen of a distal end of the microcatheter, the stentriever including: an engagement structure configured to expand when distal of the microcatheter in an expanded configuration, and an elongated member proximal of the engagement structure and extending to a proximal end of the microcatheter; and a hand control disposed on the proximal end of the microcatheter for controlling extending and retracting the engagement structure from the microcatheter.

Abstract: A clot removal device including an elongated member including a distal end; and an expandable frame including a proximal end, and one or more frame members including one or more pinching cells operable to be slidably and rotatably placed thereon, each of the pinching cells including a collapsed state within a microcatheter and an expanded state distal of the microcatheter configured to tweeze at least a portion of a clot.

Abstract: Balloon guide catheter with a balloon bonded thereto maximizing bonding strength and integrity while minimizing outer profile. Reflow jacket(s) is melted to/embedded within a braid supporting structure of the catheter securing beneath the balloon. Radially arranged apertures and/or recesses may be defined in the balloon through which adhesive is seepable upwards when secured about the catheter shaft. Proximal and distal bond interface areas of the balloon may be skived at right angles into two sections each extending radially 180°. Proximal and/or distal edges of the balloon may be flipped inwards prior to securing to the catheter shaft to form respective proximal and/or inverted bonds. During prepping of the catheter, residual air may be purged from the balloon via an exhaust hole defined in the compliant balloon or an exhaust tube secured between the exterior surface of the catheter shaft and the balloon.

Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A clot removal device including a first scaffolding section, a second scaffolding section distal of the first scaffolding section by a first hinged element including a pinching cell. The pinching cell has a collapsed state and an expanded state configured to pinch at least a portion of a clot. A third scaffolding section is distal of the second scaffolding section by a second hinged strut element including a pinching cell that has a collapsed state and an expanded state configured to pinch at least a portion of the clot. An outer diameter of the third scaffolding section is greater than an outer diameter of the second scaffolding section, which is greater than an outer diameter of the first scaffolding section.

Abstract: A clot removal device including an elongated member including a distal end; and an expandable frame including a proximal end, and one or more frame members including one or more pinching cells operable to be slidably and rotatably placed thereon, each of the pinching cells including a collapsed state within a microcatheter and an expanded state distal of the microcatheter configured to tweeze at least a portion of a clot.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A clot removal device including an elongated member including a distal end; and an expandable frame including a proximal end, and one or more frame members including one or more pinching cells operable to be slidably and rotatably placed thereon, each of the pinching cells including a collapsed state within a microcatheter and an expanded state distal of the microcatheter configured to tweeze at least a portion of a clot.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A clot removal system for removing a clot from a body vessel, the clot removal system including: a microcatheter including: a distal segment comprising a first diameter; and a proximal segment comprising a second diameter; a stentriever positionable substantially within a lumen of a distal end of the microcatheter, the stentriever including: an engagement structure configured to expand when distal of the microcatheter in an expanded configuration, and an elongated member proximal of the engagement structure and extending to a proximal end of the microcatheter; and a hand control disposed on the proximal end of the microcatheter for controlling extending and retracting the engagement structure from the microcatheter.

Abstract: A balloon guide catheter including a balloon and a catheter shaft having a central lumen defined axially therethrough, and an inflation lumen. An exterior surface of the catheter shaft has a distal reduced outer diameter recess area defined therein and a proximal reduced outer diameter recess area separated in an axial direction from the distal reduced outer diameter recess area with a discharge port of the inflation lumen disposed therebetween. The balloon is secured to the catheter shaft by adhesive pooled in the distal reduced outer diameter recess area forming a distal bonding interface area; and the proximal reduced outer diameter recess area forming a proximal bonding interface area. Heat shrink tubing is positioned about the balloon at the distal and proximal bonding interface areas.

Abstract: Balloon guide catheter with a balloon bonded thereto maximizing bonding strength and integrity while minimizing outer profile. Reflow jacket(s) is melted to/embedded within a braid supporting structure of the catheter securing beneath the balloon. Radially arranged apertures and/or recesses may be defined in the balloon through which adhesive is seepable upwards when secured about the catheter shaft. Proximal and distal bond interface areas of the balloon may be skived at right angles into two sections each extending radially 180°. Proximal and/or distal edges of the balloon may be flipped inwards prior to securing to the catheter shaft to form respective proximal and/or inverted bonds. During prepping of the catheter, residual air may be purged from the balloon via an exhaust hole defined in the compliant balloon or an exhaust tube secured between the exterior surface of the catheter shaft and the balloon.

Abstract: A clot removal device including an elongated member including a distal end; and an expandable frame including a proximal end, and one or more frame members including one or more pinching cells operable to be slidably and rotatably placed thereon, each of the pinching cells including a collapsed state within a microcatheter and an expanded state distal of the microcatheter configured to tweeze at least a portion of a clot.

Abstract: A clot removal device including a first scaffolding section, a second scaffolding section distal of the first scaffolding section by a first hinged element including a pinching cell. The pinching cell has a collapsed state and an expanded state configured to pinch at least a portion of a clot. A third scaffolding section is distal of the second scaffolding section by a second hinged strut element including a pinching cell that has a collapsed state and an expanded state configured to pinch at least a portion of the clot. An outer diameter of the third scaffolding section is greater than an outer diameter of the second scaffolding section, which is greater than an outer diameter of the first scaffolding section.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: A method or use for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

Abstract: Provided is an apparatus, system, and method for targeted memory enhancement. A computer processing circuit receives a plurality of electroencephalography (EEG) signals from a plurality of spatially separated EEG sensors located on the head of a subject that is asleep. A first process of the computer processing system determines a sleep state of the subject and upon determining that the subject is in sleep stage 2 or 3 based on a specific EEG signal, the processing system triggers a second process of the computer processing system that determines a transition event in the specific EEG signal, and upon detecting the transition event delivers an intervention to the subject designed to evoke a specific neurophysiological change to the subject.