Abstract: Crystals and structures are provided for an eukaryotic RNA polymerase, and an elongation complex containing a eukaryotic RNA polymerase. The structures and structural coordinates are useful in structural homology deduction, in developing and screening agents that affect the activity of eukaryotic RNA polymerase, and in designing modified forms of eukaryotic RNA polymerase. The structure information may be provided in a computer readable form, e.g. as a database of atomic coordinates, or as a three-dimensional model. The structures are useful, for example, in modeling interactions of the enzyme with DNA, RNA, transcription factors, nucleotides, etc. The structures are also used to identify molecules that bind to or otherwise interact with structural elements in the polymerase.

Abstract: Crystals and structures are provided for an eukaryotic RNA polymerase, and an elongation complex containing a eukaryotic RNA polymerase. The structures and structural coordinates are useful in structural homology deduction, in developing and screening agents that affect the activity of eukaryotic RNA polymerase, and in designing modified forms of eukaryotic RNA polymerase. The structure information may be provided in a computer readable form, e.g. as a database of atomic coordinates, or as a three-dimensional model. The structures are useful, for example, in modeling interactions of the enzyme with DNA, RNA, transcription factors, nucleotides, etc. The structures are also used to identify molecules that bind to or otherwise interact with structural elements in the polymerase.

Abstract: A revolver is provided that includes a frame, a barrel, a cylinder, a hammer, a trigger, and a safety lock mechanism. The safety lock mechanism includes a lockarm and a lockarm actuator. The hammer includes a normal slot and a lock slot. The lockarm includes a cam surface and hammer post, and is pivotally mounted relative to the frame. The lockarm actuator is disposed in the frame. The lockarm actuator includes a head and a cam, and the cam is aligned with the cam surface of the lockarm so as to be engageable with the cam surface. The lockarm actuator can be positioned in a safety-off condition in which the hammer post of the lockarm is received within the normal slot of the hammer and the hammer is operable. The lockarm actuator can also be positioned in a safety-on condition in which the hammer post is received within the lock slot and the hammer is inoperable.

Abstract: A revolver is provided that includes a frame, a barrel, a cylinder, a hammer, a trigger, and a safety lock mechanism. The safety lock mechanism includes a lockarm and a lockarm actuator. The hammer includes a normal slot and a lock slot. The lockarm includes a cam surface and hammer post, and is pivotally mounted relative to the frame. The lockarm actuator is disposed in the frame. The lockarm actuator includes a head and a cam, and the cam is aligned with the cam surface of the lockarm so as to be engageable with the cam surface. The lockarm actuator can be positioned in a safety-off condition in which the hammer post of the lockarm is received within the normal slot of the hammer and the hammer is operable. The lockarm actuator can also be positioned in a safety-on condition in which the hammer post is received within the lock slot and the hammer is inoperable.