Abstract: Described herein are devices and systems that can be configured to and/or capable of monitoring and/or controlling fluid flow within microchannels and/or vessels in a microphysiological model. Described herein are aspects of a system configured to monitor and/or control fluid flow in a microfluidic device that can include a manifold device, where the manifold device can include an inlet reservoir, an outlet reservoir, a pressure jumper, a sensor, and a scaffold block that can have a plurality of microfluidic channels and/or vessels. Also described herein are methods of making and using the systems and devices described herein.

Abstract: Described herein are devices and systems that can be configured to and/or capable of monitoring and/or controlling fluid flow within microchannels and/or vessels in a microphysiological model. Described herein are aspects of a system configured to monitor and/or control fluid flow in a microfluidic device that can include a manifold device, where the manifold device can include an inlet reservoir, an outlet reservoir, a pressure jumper, a sensor, and a scaffold block that can have a plurality of microfluidic channels and/or vessels. Also described herein are methods of making and using the systems and devices described herein.