Patents by Inventor Patrick Dennler
Patrick Dennler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10675359Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: September 12, 2017Date of Patent: June 9, 2020Assignees: Innate Pharma, Paul Scherrer InstitutInventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
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Patent number: 10434180Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: July 19, 2016Date of Patent: October 8, 2019Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUTInventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
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Publication number: 20190169601Abstract: The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: July 13, 2018Publication date: June 6, 2019Inventors: Eliane Fischer, Francois Romagne, Patrick Dennler
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Patent number: 10132799Abstract: Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.Type: GrantFiled: July 10, 2013Date of Patent: November 20, 2018Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUTInventors: Christian Belmant, Delphine Bregeon, Patrick Dennler, Eliane Fischer, François Romagne, Roger Schibli, Laurent Gauthier
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Patent number: 10036010Abstract: The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: November 8, 2013Date of Patent: July 31, 2018Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUTInventors: Eliane Fischer, François Romagne, Patrick Dennler
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Publication number: 20180193476Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: September 12, 2017Publication date: July 12, 2018Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
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Publication number: 20180071402Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: July 19, 2017Publication date: March 15, 2018Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Eliane Fischer, Laurent Gauthier, Francois Romagné, Roger Schibli
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Patent number: 9764038Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: December 21, 2012Date of Patent: September 19, 2017Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUTInventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
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Patent number: 9717803Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: December 21, 2012Date of Patent: August 1, 2017Assignees: INNATE PHARMA, PAUL SCHERRER INSTITUTInventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Eliane Fischer, Laurent Gauthier, Francois Romagné, Roger Schibli
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Publication number: 20160331842Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: July 19, 2016Publication date: November 17, 2016Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
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Patent number: 9427478Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: GrantFiled: December 23, 2014Date of Patent: August 30, 2016Assignees: Innate Pharma, Paul Scherrer InstitutInventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
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Publication number: 20150346195Abstract: Provided is a method for the functionalization of immunoglobulins through the use of transglutaminase, including methods for screening functionalized antibodies for characteristics of interest, antibody compositions comprising a plurality of functionalized antibodies, and functionalized antibodies with rodent constant regions.Type: ApplicationFiled: July 10, 2013Publication date: December 3, 2015Inventors: Christian Belmant, Delphine Bregeon, Patrick Dennler, Eliane Fischer, François Romagne, Roger Schibli
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Publication number: 20150284713Abstract: The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also disclosed herein are peptide tags for transglutaminase, linking reagents, functionalized antibodies, multi-specific antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: November 8, 2013Publication date: October 8, 2015Inventors: Eliane Fischer, François Romagne, Patrick Dennler
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Publication number: 20150165064Abstract: The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: December 23, 2014Publication date: June 18, 2015Inventors: Delphine Bregeon, Patrick Dennler, Christian Belmant, Laurent Gauthier, François Romagne, Eliane Fischer, Roger Schibli
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Publication number: 20140356385Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.Type: ApplicationFiled: December 21, 2012Publication date: December 4, 2014Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
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Patent number: 6649130Abstract: A hybrid reactor arrangement provides a reactive design that achieves higher acrylonitrile yield and lower catalyst circulating rate. The hybrid reactor design first passes a mixture of reactants and catalyst through a circulating bubbling bed reaction section. Heat exchange coils or other cooling medium in the bubbling bed reactor section maintain temperature in a range that will maximize the selectivity of reactants to the acrylonitrile product. The bubbling bed reactor section provides the initial conversion of the reactant. A circulating fluidized bed reaction zone finishes the conversion of reactants to a high yield under conditions that reduce the occurrence of secondary reactions that could otherwise produce unwanted by-products. The circulating fluidized bed reactor section maintains nearly plug flow conditions that allow continued conversion of unreacted feed components through primary reactions while limiting the time for secondary reactions to continue and diminish the final yield of products.Type: GrantFiled: August 10, 2000Date of Patent: November 18, 2003Assignee: UOP LLCInventors: Robert L. Zhou, W. Patrick Dennler, Anil R. Oroskar, Bipin V. Vora, Hayim Abrevaya, Laurence O. Stine
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Patent number: 6143915Abstract: A hybrid reactor arrangement provides a reactive design that achieves higher acrylonitrile yield and lower catalyst circulating rate. The hybrid reactor design first passes a mixture of reactants and catalyst through a circulating bubbling bed reaction section. Heat exchange coils or other cooling medium in the bubbling bed reactor section maintain temperature in a range that will maximize the selectivity of reactants to the acrylonitrile product. The bubbling bed reactor section provides the initial conversion of the reactant. A circulating fluidized bed reaction zone finishes the conversion of reactants to a high yield under conditions that reduce the occurrence of secondary reactions that could otherwise produce unwanted by-products. The circulating fluidized bed reactor section maintains nearly plug flow conditions that allow continued conversion of unreacted feed components through primary reactions while limiting the time for secondary reactions to continue and diminish the final yield of products.Type: GrantFiled: November 23, 1998Date of Patent: November 7, 2000Assignee: UOP LLCInventors: Lubo Zhou, W. Patrick Dennler, Anil R. Oroskar, Bipin V. Vora, Hayim Abrevaya, Laurence O. Stine