Abstract: The present disclosure relates to the synthesis of cyclic peptides that are able to effectively deliver cargo, e.g., a therapeutic moiety (TM), inside a cell to treat a variety of conditions and diseases.

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

Abstract: Compounds comprising a cyclic peptide, such as a cyclic cell penetrating peptide, and an antisense compound are provided. The antisense compound binds to a gene having an expanded CTG repeat or a gene transcript having an expanded CUG repeat. The compounds can be delivered to subjects to treat diseases associated with expanded CTG CUG repeats, such as myotonic dystrophy type 1 (DM1), spinocerebellar ataxia-8 (SCA8), and Huntington disease like-2 (HDL2).

Abstract: Provided herein are compounds that include a cyclic cell penetrating peptide, a therapeutic moiety and a modulatory peptide, wherein the modulatory peptide modulates the tissue distribution and/or retention of the compound in vivo. Also provide herein are methods of modulating tissue distribution and/or retention of intracellular therapeutics using the aforementioned compounds.

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

Abstract: A process for producing a high density aluminum alloy part from a green part like those produced by binder jet additive manufacturing is described. The process utilizes a build powder that includes a densification aid mixed with the aluminum alloy powder and gets incorporated into the green part during the printing process. In some cases, a continuous high flow of nitrogen gas and controlled heating of the green part and provides a high density aluminum alloy part exhibiting densities of 95% or greater.

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

Abstract: Degradation compounds include a cyclic cell penetrating peptide (cCPP) and a degradation construct. The degradation construct includes a degradation moiety and a targeting moiety. The targeting moiety binds a target protein. When the targeting moiety is bound to the target protein, the degradation moiety mediates degradation of the target protein. The cCPP facilitates transfer of the degradation construct into a cell. The degradation compound may further include an exocyclic peptide to enhance endosomal escape of the compound or degradation construct once inside the cell.

Abstract: A tooth for use on a rotating element has a base attached to the rotating element and a cutter assembly removably attached to the base. The cutter assembly has an upper ramp surface and a blade. In another aspect, the tooth has a base attached to the rotating element and the base includes one or more base tab and slot elements. The tooth also includes a cutter assembly that has one or more cutter assembly tab and slot elements. Each of the one or more cutter assembly tab and slot elements is configured for a mating engagement with a corresponding one of the one or more base tab and slot elements. In another aspect, a rotary drum for use on a vegetation cutting machine includes a plurality of teeth that each have a base attached to the rotary drum and a cutter assembly removably attached to the base.

Abstract: A tooth for use on a rotating element has a base attached to the rotating element and a cutter assembly removably attached to the base. The cutter assembly has an upper ramp surface and a blade. In another aspect, the tooth has a base attached to the rotating element and the base includes one or more base tab and slot elements. The tooth also includes a cutter assembly that has one or more cutter assembly tab and slot elements. Each of the one or more cutter assembly tab and slot elements is configured for a mating engagement with a corresponding one of the one or more base tab and slot elements. In another aspect, a rotary drum for use on a vegetation cutting machine includes a plurality of teeth that each have a base attached to the rotary drum and a cutter assembly removably attached to the base.

Abstract: A powered mulcher is configured for attachment to a vehicle. The mulcher includes a frame assembly and a drum assembly contained within the frame assembly. The drum assembly includes a substantially cylindrical drum and a cutting array mounted to the drum. The cutting array includes a plurality of flights connected to the drum and a plurality of cutters attached to each of the plurality of flights. The plurality of flights are configured to push processed plant debris away from the ends and middle of the drum.

Abstract: A portion of a replaceable component of an imaging device is selectively deformed or melted.

Abstract: In one embodiment, a material supply device includes: a reservoir defined at least in part by a exterior wall, the wall having an elongated opening therein; an elongated surface close to and extending along the opening in the exterior wall of the reservoir, the surface movable relative to the wall; and a means for moving material directly from the reservoir to the surface through the slot.

Abstract: Systems and methods are described herein for enabling a burst mode in a printing device to accelerate a first page out time for a print job. A warm up period typically allowed in a laser printer is used to heat up a fuser to an optimum temperature. When certain printing conditions exist, burst mode enables the printer to omit the warm up period and operate with the fuser at a lower temperature. The lower temperature is acceptable for most printing conditions without degrading print quality. If the print conditions indicate the warm up period is desirable, then burst mode is not enabled. Print conditions include temperature, humidity, print job length, print job coverage, print job media size, simplex/duplex mode, and the like.

Abstract: A cartridge for a printing device includes first and second portions coupled to one another and capable of moving relative to each other, one or more rollers situated at the first portion, a photoconductor situated at the second portion, and a lock mechanism. The rollers are in contact with the photoconductor in a first position of the first and the second portions. The lock mechanism maintains the first and the second portions in a second position in which the rollers are separated from the photoconductor.

Abstract: An amount of material in a container is determined by measuring a time it takes for an object to move through the material, and determining the amount of material based on the measured time.

Abstract: A portion of a replaceable component of an imaging device is selectively deformed or melted.

Abstract: A cartridge for a printing device includes first and second portions coupled to one another and capable of moving relative to each other, one or more rollers situated at the first portion, a photoconductor situated at the second portion, and a lock mechanism. The rollers are in contact with the photoconductor in a first position of the first and the second portions. The lock mechanism maintains the first and the second portions in a second position in which the rollers are separated from the photoconductor.

Abstract: Systems, methods, computer-readable media, and other embodiments are described for a system that estimates usage of a marking material in a print cartridge. One example system can include a coverage logic configured to determine a coverage value which is an average amount of marking material that covers a printed page of print media based on previous usage data. The system can also include a marking material remaining logic configured to determine a marking material remaining value for the print cartridge based, at least in part, on the coverage value.