Abstract: Compounds comprising a cyclic peptide, such as a cyclic cell penetrating peptide, and an antisense compound are provided. The antisense compound binds to a gene having an expanded CTG repeat or a gene transcript having an expanded CUG repeat. The compounds can be delivered to subjects to treat diseases associated with expanded CTG CUG repeats, such as myotonic dystrophy type 1 (DM1), spinocerebellar ataxia-8 (SCA8), and Huntington disease like-2 (HDL2).

Abstract: Provided herein are compounds that include a cyclic cell penetrating peptide, a therapeutic moiety and a modulatory peptide, wherein the modulatory peptide modulates the tissue distribution and/or retention of the compound in vivo. Also provide herein are methods of modulating tissue distribution and/or retention of intracellular therapeutics using the aforementioned compounds.

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

Abstract: A process for producing a high density aluminum alloy part from a green part like those produced by binder jet additive manufacturing is described. The process utilizes a build powder that includes a densification aid mixed with the aluminum alloy powder and gets incorporated into the green part during the printing process. In some cases, a continuous high flow of nitrogen gas and controlled heating of the green part and provides a high density aluminum alloy part exhibiting densities of 95% or greater.

Abstract: The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.

Abstract: Degradation compounds include a cyclic cell penetrating peptide (cCPP) and a degradation construct. The degradation construct includes a degradation moiety and a targeting moiety. The targeting moiety binds a target protein. When the targeting moiety is bound to the target protein, the degradation moiety mediates degradation of the target protein. The cCPP facilitates transfer of the degradation construct into a cell. The degradation compound may further include an exocyclic peptide to enhance endosomal escape of the compound or degradation construct once inside the cell.

Abstract: A tooth for use on a rotating element has a base attached to the rotating element and a cutter assembly removably attached to the base. The cutter assembly has an upper ramp surface and a blade. In another aspect, the tooth has a base attached to the rotating element and the base includes one or more base tab and slot elements. The tooth also includes a cutter assembly that has one or more cutter assembly tab and slot elements. Each of the one or more cutter assembly tab and slot elements is configured for a mating engagement with a corresponding one of the one or more base tab and slot elements. In another aspect, a rotary drum for use on a vegetation cutting machine includes a plurality of teeth that each have a base attached to the rotary drum and a cutter assembly removably attached to the base.

Abstract: A tooth for use on a rotating element has a base attached to the rotating element and a cutter assembly removably attached to the base. The cutter assembly has an upper ramp surface and a blade. In another aspect, the tooth has a base attached to the rotating element and the base includes one or more base tab and slot elements. The tooth also includes a cutter assembly that has one or more cutter assembly tab and slot elements. Each of the one or more cutter assembly tab and slot elements is configured for a mating engagement with a corresponding one of the one or more base tab and slot elements. In another aspect, a rotary drum for use on a vegetation cutting machine includes a plurality of teeth that each have a base attached to the rotary drum and a cutter assembly removably attached to the base.

Abstract: A powered mulcher is configured for attachment to a vehicle. The mulcher includes a frame assembly and a drum assembly contained within the frame assembly. The drum assembly includes a substantially cylindrical drum and a cutting array mounted to the drum. The cutting array includes a plurality of flights connected to the drum and a plurality of cutters attached to each of the plurality of flights. The plurality of flights are configured to push processed plant debris away from the ends and middle of the drum.

Abstract: A phased microphone array capable of being placed in the free stream flow of a wind tunnel test section. The array consists of a plane of microphones on arms radiating out from a central hub. Microphones are placed along the length of the arms. The array is to be fastened to an articulated mount which allows it to be repositioned and be placed in a number of viewing positions. The ideal arms are symmetric airfoils that rotate about the longitudinal axis of the arm so that in free flow the airfoils point into the oncoming flow. Microphones placed at the leading edge will be located at stagnation points decreasing wind turbulence and boundary layer effects.

Abstract: Functional beamforming is a vast improvement over classical beamforming methods. Let v be a power greater than unity. The v-th root of the array cross spectral matrix is computed and used in classical beamforming. The v-th power of the resulting beamform map is then computed. This procedure significantly reduced sidelobes, increasing the dynamic range of the results. Assuming the standard model of an incoherent source distribution, it is shown that the computed map values are greater than or equal to the underlying source strengths. Increasing v decreases the map values, steadily reducing sidelobes and peak widths. Quantitative component spectra can be computed by integrating the maps over regions of interest without the errors caused by sidelobes when integrating classical maps. Deconvolution processing is unnecessary. The time and other computer resources required for the computation are virtually identical to classical beamforming.

Abstract: A phased microphone imaging array and repeatable sound source are used in concert to determine absorption and reflection coefficients of materials and spaces across a continuous frequency domain. Coefficients can be determined at normal and oblique incidences to the surface using beamforming software. The invention can be used in-situ without needing to alter the environment in which it is testing. Accurate results can be obtained at any distance from the array and sound source to the testing surface with relatively little material.

Abstract: A disposable absorbent product extends longitudinally along a longitudinal axis and laterally along a transverse axis, with the transverse axis conceptually dividing the product into first and second hemispheres. The product has a permeable topsheet, an impermeable backsheet overlaying the topsheet, and an absorbent core disposed between the topsheet and the backsheet for storing fluid secreted by the wearer of the disposable absorbent product. Each of a pair of side regions extends laterally outboard of the absorbent core, with each side region having a first face configured to face the wearer during use and a second face opposite the first face. The product also has at least one skin-friendly adhesive element in the first hemisphere in at least one of the side regions for temporarily attaching the disposable absorbent product to the skin of the wearer.

Abstract: A disposable absorbent product includes a topsheet, a backsheet overlaying the topsheet, and an absorbent core disposed between the topsheet and the backsheet for absorbing fluid secreted by a wearer of the product. The product also includes a wetness indicating material in the topsheet, the backsheet, or the absorbent core, with the wetness indicating material having a water-soluble element and an inodorous component trapped by the water-soluble element. The water-soluble element is configured to degrade in the presence of fluid secreted by the wearer of the product, thereby releasing the inodorous component into the surrounding air.

Abstract: A disposable absorbent product extends longitudinally along a longitudinal axis and laterally along a transverse axis, with the transverse axis conceptually dividing the product into first and second hemispheres. The product has a permeable topsheet, an impermeable backsheet overlaying the topsheet, and an absorbent core disposed between the topsheet and the backsheet for storing fluid secreted by the wearer of the disposable absorbent product. Each of a pair of side regions extends laterally outboard of the absorbent core, with each side region having a first face configured to face the wearer during use and a second face opposite the first face. The product also has at least one skin-friendly adhesive element in the first hemisphere in at least one of the side regions for temporarily attaching the disposable absorbent product to the skin of the wearer.

Abstract: Methods and systems for monitoring particulate in a flow of gases are provided. A particulate monitor system includes an emitter coupled to an exhaust duct and downstream from a turbine engine. The emitter emits light at a predetermined intensity through a flow of gases discharged from the turbine engine into the exhaust duct. A receiver is coupled to the exhaust duct and oriented to receive at least a portion of the light emitted from the emitter. The receiver generates a first signal indicative of an intensity of the emitted light received. A controller is coupled in communication with the receiver. The controller is configured to generate, based on the first signal, an output signal corresponding to a variation in intensity of the portion of the emitted light received. A monitor in communication with the controller receives the output signal from the controller.

Abstract: A portion of a replaceable component of an imaging device is selectively deformed or melted.

Abstract: Aqueous-form additive systems, and methods of blending the same with a matrix resin, are disclosed whereby acrylic-based impact modifier compositions, butadiene-based impact modifier compositions and acrylic-based processing aids are used in aqueous form without the need for isolation to the traditional powder-form. The aqueous additive systems of the present invention provide a means for the design of novel additive compositions. The aqueous additive systems of the present invention also provide a great degree of flexibility in preparation of matrix resin blends and formulations. Additionally, the aqueous additive systems of the present invention allow for the reduced cost of manufacturing additives and reduced cost in blending matrix resin formulations.

Abstract: In one embodiment, a material supply device includes: a reservoir defined at least in part by a exterior wall, the wall having an elongated opening therein; an elongated surface close to and extending along the opening in the exterior wall of the reservoir, the surface movable relative to the wall; and a means for moving material directly from the reservoir to the surface through the slot.