Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: The present invention relates to antibodies binding alpha synuclein and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

Abstract: A fencing scoring system may include a controller configured to output a signal indicative of a hit. The output signal may be in response to counts of edges of one or more oscillating signals having a variable frequency deviating from a threshold over a period. The counts may be of edges that are rising. The counts may be of edges that are falling. The counts may be of edges that are rising and falling. The frequency may be based on a capacitance of a circuit. A portion of the capacitance may be from a fencing equipment component. The equipment component may be a lamé. The equipment component may be a weapon.

Abstract: The invention pertains to a method of treating Parkinson's disease (PD) in a mammal, comprising administering a first pharmaceutical agent and a second pharmaceutical agent, wherein the first pharmaceutical agent is an antagonist of the adenosine receptor 2 (A2A) and the second pharmaceutical agent is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subtype NR2B.

Abstract: The invention pertains to a method of treating Parkinson's disease (PD) in a mammal, comprising administering a first pharmaceutical agent and a second pharmaceutical agent, wherein the first pharmaceutical agent is an antagonist of the adenosine receptor 2 (A2A) and the second pharmaceutical agent is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subtype NR2B.

Abstract: The invention pertains to a method of treating Parkinson's disease (PD) in a mammal, comprising administering a first pharmaceutical agent and a second pharmaceutical agent, wherein the first pharmaceutical agent is an antagonist of the adenosine receptor 2 (A2A) and the second pharmaceutical agent is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subtype NR2B.

Abstract: An absorbent core comprises a multi-microlayer film having a plurality of coextruded microlayers that can perform the multiple functions of acquisition, retention and distribution of fluids. The multi-microlayer films may be formed in a coextrusion process. Each microlayer is manufactured from either a high-recovery polymer or a low-recovery polymer and may be in a substantially alternating configuration within the film. A disruptive force, such as a stretching force, can be applied to at least one portion of the multi-microlayer film to partially delaminate the low-recovery microlayer from the high-recovery microlayer to form corrugations in that portion. The multi-microlayer film can be apertured and additives may be included in either polymer layer.

Abstract: A multilayer film includes a plastic layer and an elastomeric layer. The plastic layer can contain a co-polyester of terepthalic acid, adipic acid and butanediol, and the elastomeric layer can contain a polyurethane elastomer. The plastic layer and/or the elastomeric layer can contain filler particles, and may be present as a bilayer laminate. The plastic layer and a filled elastomeric layer can also be combined with an unfilled elastomeric layer to form a tri-layer laminate. The multilayer films can provide breathable films with improved degradability, stretchability and recoverability, and tactile feel.

Abstract: A multilayer film includes a plastic layer and an elastomeric layer. The plastic layer and/or the elastomeric layer can contain filler particles, and may be present as a well bonded bilayer laminate. The plastic layer and a filled elastomeric layer can also be combined with an unfilled elastomeric layer to form a tri-layer laminate. The film has an average roughness of about 500 to about 1,000 nanometers. The multilayer films can provide breathable films with improved degradability, stretchability and recoverability, and tactile feel.

Abstract: A tool-supporting attachment to be mounted on a vehicle for use in suspending motorized tools which must be carried on long distances is disclosed. This attachment comprises levelling means to permit to its upper frame portion to always be in a substantially horizontal position with respect to the ground on which the vehicle is moved such that the tools are always kept at a constant height above the ground.

Abstract: What is disclosed is a door opener for a bus and the like having a pair of doors pivotally mounted on each side of a door opening on respective door shafts characterized by respective door bell cranks connected with the door shaft so as to effect desired rotation thereof; a central bell crank journalled for pivotal movement for opening the doors; and a pair of respective linking arms connected respectively with the central bell crank and with respective door bell cranks, at least one of the linking arms including respective telescoping members and biasing means for maintaining a noise-abating force on the doors; motor and interconnection mechanism for effecting controlled pivotal rotation of the central bell crank for opening the doors and for closing the doors and a safety override for disengaging the motor to allow the doors to be opened manually in the event of an emergency. Also disclosed is the respective preferred embodiment.