Abstract: Provided are methods for treating pemphigus using an FcRn antagonist such as efgartigimod. The methods of the invention provide a rapid onset of action to enable early disease control and maintenance of clinical remission, with or without a minimal dose of corticosteroids.

Abstract: A radial support bearing assembly for use within a steering column assembly having an outer tube and a shaft, including at least one inner ring defining an inner raceway, the inner ring being axially fixed relative to the shaft, at least one outer ring defining an outer raceway, and a plurality of roller elements disposed between the at least one inner ring and the at least one outer ring in rolling contact with the inner raceway and the outer raceway. The inner ring is in direct contact with the shaft and has a circular cross-section as taken in a plane parallel to a longitudinal center axis of the shaft.

Abstract: It is an object of the invention to provide a process for producing an organic acid, comprising: providing an incoming stream containing an organic acid and impurities; subjecting said incoming stream to a step of chromatographic separation, using a solution of mineral acid as an eluent, so as to collect an extract and a raffinate, the organic acid being recovered in the extract; and subjecting the raffinate to an electrodialysis step, so as to collect a diluate and a concentrate, the mineral acid being concentrated in the concentrate. The invention also provides an installation for implementing this process.

Abstract: A radial support bearing assembly for use within a steering column assembly having an outer tube and a shaft, including at least one inner ring defining an inner raceway, the inner ring being axially fixed relative to the shaft, at least one outer ring defining an outer raceway, and a plurality of roller elements disposed between the at least one inner ring and the at least one outer ring in rolling contact with the inner raceway and the outer raceway. The inner ring is in direct contact with the shaft and has a circular cross-section as taken in a plane parallel to a longitudinal center axis of the shaft.

Abstract: A radial support bearing assembly for use within a steering column assembly having an outer tube and a shaft 50, including at least one inner ring 70 defining an inner raceway, the inner ring 70 being axially fixed relative to the shaft 50, at least one outer ring 30 defining an outer raceway, and a plurality of roller elements 60 disposed between the at least one inner ring 70 and the at least one outer ring 30 in rolling contact with the inner raceway and the outer raceway. The inner ring 70 is in direct contact with the shaft 50 and has a circular cross-section as taken in a plane parallel to a longitudinal center axis of the shaft 50.

Abstract: It is an object of the invention to provide a process for producing an organic acid, comprising: providing an incoming stream containing an organic acid and impurities; subjecting said incoming stream to a step of chromatographic separation, using a solution of mineral acid as an eluent, so as to collect an extract and a raffinate, the organic acid being recovered in the extract; and subjecting the raffinate to an electrodialysis step, so as to collect a diluate and a concentrate, the mineral acid being concentrated in the concentrate. The invention also provides an installation for implementing this process.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: A radial support bearing assembly for use within a steering column assembly having an outer tube and a shaft 50, including at least one inner ring 70 defining an inner raceway, the inner ring 70 being axially fixed relative to the shaft 50, at least one outer ring 30 defining an outer raceway, and a plurality of roller elements 60 disposed between the at least one inner ring 70 and the at least one outer ring 30 in rolling contact with the inner raceway and the outer raceway. The inner ring 70 is in direct contact with the shaft 50 and has a circular cross-section as taken in a plane parallel to a longitudinal center axis of the shaft 50.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and the features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: The invention relates to a device (1) for delivering two predetermined doses of a product (3), comprising: —a container (2) for containing said product, said container having a distal end (2d) through which the product is delivered under the distal pressure of a piston, —a pusher (7) movable with respect to said container for causing said piston (4) to move in the distal direction from an initial position, in which none of said product has been expelled to a first position, in which a first dose of said product has been expelled, and to a second position, in which a second dose of said product has been expelled, —a holder body (15) receiving said container and said pusher (7), —biasing means (22) for urging said pusher (7) in the distal direction, from the initial to the first position, and to the second position, —first and second retaining means (9, 11, 19) for maintaining said pusher (7) in said initial position, and in said first position, —first and second actuation means (18) to deactivate said first an

Abstract: The invention relates to a pharmaceutical composition comprising a combination of glycerol, white soft paraffin and liquid paraffin as active ingredients for topical use to treat uremic xerosis and/or uremic pruritus.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing the plunger. The plunger (30) has features which divide the dose into discrete intervals. As the plunger is moved during delivery, features on the plunger and features connected to the barrel interact to provide for intermittent stops to the injection process. Other aspects of the device provide-for reduced dead space, safety and selective interconnection with other devices. Thus, the delivery device divides the dose.

Abstract: The invention relates to a device (1) for delivering two predetermined doses of a product (3), comprising:—a container (2) for containing said product, said container having a distal end (2d) through which the product is delivered under the distal pressure of a piston,—a pusher (7) movable with respect to said container for causing said piston (4) to move in the distal direction from an initial position, in which none of said product has been expelled to a first position, in which a first dose of said product has been expelled, and to a second position, in which a second dose of said product has been expelled,—a holder body (15) receiving said container and said pusher (7),—biasing means (22) for urging said pusher (7) in the distal direction, from the initial to the first position, and to the second position,—first and second retaining means (9, 11, 19) for maintaining said pusher (7) in said initial position, and in said first position,—first and second actuation means (18) to deactivate said first and seco

Abstract: The disclosure relates to a porous support for tangential flow filtration with a covering surrounding the outer surface of the support, the covering having one or more holes for the evacuation of fluid through the outer surface. The disclosure also relates to a method for preparing such a support.

Abstract: Storage-stable sols are comprised of a colloidal dispersion of Ce (IV) values in an aqueous medium, and optionally colloidal particulates of a cation of a metal M, with said colloidal dispersion being "supersaturated" in [OH.sup.- ] ions.

Abstract: Provided is a ceric oxide having a specific surface of at least 85 m.sup.2 /g after calcination between 350.degree. and 550.degree. C., and being further characterized in that it has a pore volume of at least 0.15 cm.sup.3 /g and a median pore diameter greater than 50 .ANG.. The ceric oxide is prepared by destabilizing an aqueous colloidal dispersion of a cerium (IV) compound by the addition of base thereto, separating the precipitate which results and subjecting it to a heat treatment.