Abstract: An adjustable load mechanism for an exercise device, the adjustable load mechanism including: at least one load point for application of force by a user, and a first load source comprising a tension assembly including an elastic portion, wherein the tension assembly is connected directly or indirectly to the at least one load point, and whereby a force applied to the at least one load point is transferred along an effective path through the tension assembly, and an adjusting mechanism operable to adjust the tension of the tension assembly, so as to vary the load required on the at least one load point, wherein the adjusting mechanism is operable whilst a load is applied to the tension assembly.

Abstract: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Abstract: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Abstract: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Abstract: The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Abstract: The invention concerns biosensors, the method for obtaining them and their uses in particular for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or a hapten, in a heterogeneous population. Said biosensors consist of (i) at least a protein-type receptor fragment, capable of binding with a suitable ligand via an active site and in which fragment, at least one of its amino acid residues, located in the proximity of said active site is naturally present in the form of a Cys residue or is substituted in Cys residue, and (ii) a fluorophore coupled with said Cys residue(s).