Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: Methods and apparatus are provided for minimizing the inherent time delays within external defibrillators. The methods and apparatuses utilize timing schemes for initiation and completion of charging of an energy storage device of an external defibrillator, measuring one or physical parameters of the patient and conducting a physiology analysis of the patient. The initiation and completion of one or more of these activities are arranged so that the energy storage device is charged to a desired level and available for a defibrillation shock to the patient with minimal delay after activation of the external defibrillator.

Abstract: An external defibrillator includes a therapy delivery circuit, a sensor, and a processor. The therapy delivery circuit is configured to be electrically charged and to deliver electrical therapy to a patient. The sensor is configured to sense a physiological condition of the patient and generate data indicative of a probability that therapy will be delivered to the patient. The processor is configured to analyze data generated by the sensor to determine whether there is a threshold level of the probability that the therapy delivery will be delivered to the patient, if the probability is at least at the threshold level, charge the therapy delivery circuit, and determine whether therapy delivery is advisable based on the physiological condition of the patient after determining whether the probability is at least at the threshold level.

Abstract: Signal data obtained from a piezoelectric sensor placed on a patient's body is used to detect the presence of a cardiac pulse. The piezoelectric sensor has a transducing element adapted to sense movement due to a cardiac pulse and produce piezoelectric signal data in response thereto. Processing circuitry analyzes the piezoelectric signal data for a feature indicative of a cardiac pulse and determines whether a cardiac pulse is present in the patient based on the feature. In one aspect, the feature may be a temporal feature such as a relative change in energy. In another aspect, the feature may be a spectral feature such as the energy or frequency of a peak in the energy spectrum of the signal. In yet another aspect, the feature may be obtained by comparing the piezoelectric signal data with a previously-identified pattern known to predict the presence of a cardiac pulse. Multiple features may also be obtained from the piezoelectric signal data and classified to determine the presence of a cardiac pulse.

Abstract: Methods and apparatus are provided for minimizing the inherent time delays within external defibrillators. The methods and apparatuses utilize timing schemes for initiation and completion of charging of an energy storage device of an external defibrillator, measuring one or physical parameters of the patient and conducting a physiology analysis of the patient. The initiation and completion of one or more of these activities are arranged so that the energy storage device is charged to a desired level and available for a defibrillation shock to the patient with minimal delay after activation of the external defibrillator.

Abstract: An external defibrillator includes a therapy delivery circuit, a sensor, and a processor. The therapy delivery circuit is configured to be electrically charged and to deliver electrical therapy to a patient. The sensor is configured to sense a physiological condition of the patient and generate data indicative of a probability that therapy will be delivered to the patient. The processor is configured to analyze data generated by the sensor to determine whether there is a threshold level of the probability that the therapy delivery will be delivered to the patient, if the probability is at least at the threshold level, charge the therapy delivery circuit, and determine whether therapy delivery is advisable based on the physiological condition of the patient after determining whether the probability is at least at the threshold level.

Abstract: Methods and apparatus are provided for minimizing the inherent time delays within external defibrillators. The methods and apparatuses utilize timing schemes for initiation and completion of charging of an energy storage device of an external defibrillator, measuring one or physical parameters of the patient and conducting a physiology analysis of the patient. The initiation and completion of one or more of these activities are arranged so that the energy storage device is charged to a desired level and available for a defibrillation shock to the patient with minimal delay after activation of the external defibrillator.

Abstract: A method of delivering electrical therapy to a patient by a medical device includes activating the medical device and performing a first analysis of a first set of data signals sensed by the medical device. If the first analysis shows the first set of data signals meets a first criterion, then charging of an energy delivery circuit is commenced upon completion of the first analysis. A second analysis of a second set of data signals from the patient is performed, and if the second analysis determines that the second set of data signals meet a second criterion, the therapy is delivered. The steps of performing the first analysis and performing the second analysis may be begun at substantially the same time. The step of charging may overlap in time with the step of performing a second analysis. The medical device may be an external defibrillator and the therapy may be a defibrillating shock.

Abstract: Defibrillator assemblies and methods to wirelessly transfer energy from an external source to a battery or other rechargeable power source within the defibrillator assembly. The transfer of energy may be through a non-contact interface on a defibrillator cradle or a docking station that mounts the defibrillator. The rate of energy transfer may be equal to the energy drain caused by self-discharge and automated self-testing. Accordingly, since the rate of energy transfer is lower than that required to run the defibrillator system continuously, several wireless methods of energy transfer may be used. In addition, the defibrillator assembly may communicate diagnostic and non-diagnostic data to the external source.

Abstract: Defibrillator assemblies and methods to wirelessly transfer energy from an external source to a battery or other rechargeable power source within the defibrillator assembly. The transfer of energy may be through a non-contact interface on a defibrillator cradle or a docking station that mounts the defibrillator. The rate of energy transfer may be equal to the energy drain caused by self-discharge and automated self-testing. Accordingly, since the rate of energy transfer is lower than that required to run the defibrillator system continuously, several wireless methods of energy transfer may be used. In addition, the defibrillator assembly may communicate diagnostic and non-diagnostic data to the external source.

Abstract: Delivery of energy by a defibrillator or other medical device is inhibited when the processor or software that controls a module of the medical device operates abnormally. A windowed watchdog timer (WWDT) incorporated into one module of the medical device is used to control the operation of other modules of the medical device via a software-based extension technique. As a result, the risk of harm to the patient is reduced compared to medical devices that incorporate over-limit type watchdog timers. In addition, costs associated with implementing WWDTs in multiple modules of the defibrillator are avoided, thereby lowering the overall cost of implementation.

Abstract: Methods and apparatus are provided for minimizing the inherent time delays within external defibrillators. The methods and apparatuses utilize timing schemes for initiation and completion of charging of an energy storage device of an external defibrillator, measuring one or physical parameters of the patient and conducting a physiology analysis of the patient. The initiation and completion of one or more of these activities are arranged so that the energy storage device is charged to a desired level and available for a defibrillation shock to the patient with minimal delay after activation of the external defibrillator.

Abstract: A method and apparatus for performing self-tests on defibrillation and pacing circuits including a patient isolation switch is disclosed. Tests are provided for the defibrillation and pacing circuitry as well as the isolation switch. For testing the defibrillation circuitry, the impedance drive circuits and preamplifier may be utilized such that the energy storage capacitor is not required to be charged and discharged during the test, thus conserving energy. For testing the pacing circuitry and the isolation switch, the defibrillation circuitry is utilized. For certain of the tests, the test stimulus is the output voltage on the energy storage capacitor, while for other tests the test stimulus may be the pace current as indicated by the voltage across the input to the preamplifier. Alternative tests may be performed depending on whether the impedance at the output of the defibrillator is determined to be an open circuit or a short circuit.

Abstract: A method and apparatus for performing self-tests on defibrillation and pacing circuits including a patient isolation switch is disclosed. Following a test of the defibrillation and pacing circuitry, the isolation switch is tested by closing certain switches within the defibrillation circuitry so as to create a circuit path, and then opening and closing the isolation switch. Alternative tests may be performed depending on whether the impedance at the output of the defibrillator is determined to be an open circuit or a short circuit. If the output is determined to be an open circuit, then the test monitors the voltage across the output of the defibrillator as indicated by the voltage of a DC offset of a preamplifier coupled to the output of the defibrillator. For the short circuit test, the voltage on the energy storage capacitor is monitored.

Abstract: Delivery of energy by a defibrillator or other medical device is inhibited when the processor or software that controls a module of the medical device operates abnormally. A windowed watchdog timer (WWDT) incorporated into one module of the medical device is used to control the operation of other modules of the medical device via a software-based extension technique. As a result, the risk of harm to the patient is reduced compared to medical devices that incorporate over-limit type watchdog timers. In addition, costs associated with implementing WWDTs in multiple modules of the defibrillator are avoided, thereby lowering the overall cost of implementation.

Abstract: The present invention pertains to a method for efficiently introducing exogenous genes into stem cells, particularly human stem cells. The method optionally includes the steps of inducing the proliferation of target cells by pre-stimulation with cytokines and/or growth factors, followed by incubating these cells with RD114-pseudotyped vector particles. In a specific embodiment, the vector particles are retronectin-immobilized or ultracentrifugation-concentrated retroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein. The present invention further discloses a method for somatic gene therapy, which can be used for various therapeutic applications and involves introducing a gene of interest contained within the retroviral genome into human repopulating stem cells followed by introducing these cells into a human host.

Abstract: The present invention provides a portable defibrillator having a capacitor adapted to receive an electrical charge to deliver a defibrillation charge. Power terminals are provided to receive line power. A charging circuit is provided to charge the capacitor from line power after the power terminals receive line power. Therefore, the defibrillator is capable of receiving line power, such as standard 120 VAC, to charge the defibrillator's capacitor. By charging the capacitor directly through line power, the capacitor is charged in much less time than searching for and replacing a defibrillator battery.

Abstract: The invention is directed to external defibrillators that are powered by fuel cells. A fuel cell provides a voltage to power components of a defibrillator, such as a processor and a user interface, and to charge an energy storage circuit, e.g., a capacitor, that stores energy for delivery to a patient as a defibrillation shock. A user may use an activator to activate the fuel cell. In some embodiments, the activator includes a button that a user actuates to cause delivery of fuel to the fuel cell.