Abstract: The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where R1 is an unsubstituted C1-C12 alkyl; and R2, R3, and R4 are each independently H or —C(O)—(unsubstituted C1-C12 alkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.

Abstract: The present disclosure is directed to a method for cultivating a Bordetella species, comprising: cultivating a Bordetella species under aerobic conditions in a liquid culture medium; and maintaining a pH of the liquid culture medium by using a strong acid, such as nitric acid, or using a first and second acid, wherein the first acid is an inorganic acid that dissociates essentially completely in water, such as nitric acid, hydrochloric acid or sulfuric acid, and wherein the second acid is an inorganic acid having an acid dissociation constant (pKa) of greater than 1, such as phosphoric acid. Methods for increasing the yield of Bordetella fimbrial agglutinogen 2 and fimbrial agglutinogen 3 (FIM2/3) in a supernatant fraction from a Bordetella culture are also provided.

Abstract: The present disclosure relates to compounds according to Formula I (I) or a pharmaceutically acceptable salt and/or solvate thereof, as well as compositions including such compounds and uses thereof, where R1 is an unsubstituted C1-C12 alkyl; and R2, R3, and R4 are each independently H or —C(O)—(unsubstituted C1-C12 alkyl). Among other things, the present disclosure evidences that the significant upregulation of CD20 by the inhibition of a-mannosidase enzymes by compounds of the present technology potentiates the activity of anti-CD20 mAbs and importantly sensitize cell lines that are resistant to the action of these antibodies.

Abstract: A mobile tracking system including an antenna, gimbal, and GPS subsystem. The mobile tracking system is operable with a plurality of models of gimbal and can automatically determine gimbal parameters based upon a detected model. This allows for plug and play of several gimbal models without the need for further input provided by a user. The mobile tracking system can also identify positional information for the system itself as well as for a tracked node, and can provide gimbal pan/tilt instructions based upon both. This allows for accurate tracking in an environment where the MTS itself is moving.

Abstract: Systems and methods of epidemiological modeling using machine learning are provided, and can include receiving values for an occurrence of the infectious disease during a first time period, generating, from a model trained by a machine learning system, predictions for the occurrence of the infectious disease over a second time period, performing, by a simulator using the predictions, one or more simulations of the occurrence of the infectious disease in one or more geographic regions during one or more time periods subsequent to the second time period, and providing, to a user interface, a first simulation of the one or more simulations performed by the simulator for a first geographic region of the one or more geographic regions during a time period of the one or more time periods.

Abstract: The present disclosure is directed to a method for cultivating a Bordetella species, comprising: cultivating a Bordetella species under aerobic conditions in a liquid culture medium; and maintaining a pH of the liquid culture medium by using a strong acid, such as nitric acid, or using a first and second acid, wherein the first acid is an inorganic acid that dissociates essentially completely in water, such as nitric acid, hydrochloric acid or sulfuric acid, and wherein the second acid is an inorganic acid having an acid dissociation constant (pKa) of greater than 1, such as phosphoric acid. Methods for increasing the yield of Bordetella finbria agglutinogen 2 and fimbrial agglutinogen 3 (FIM2/3) in a supernatant fraction from a Bordetella culture are also provided.

Abstract: An apparatus for charging an electronic device is disclosed. The apparatus includes a wearable strap and an energy producing unit embedded in the wearable strap including a removable energy storage unit attached to the wearable strap and in communication with the energy producing unit. The removable energy storage unit has a first side and an opposite second side, the first and second side attached to and detachable from the wearable strap and the first side is configured to plug into multiple external electronic devices enabling the removable energy storage unit to transfer stored energy into the external electronic device for charging the external electronic devices and the first side of the removable energy storage unit communicates with the energy producing unit.

Abstract: A mobile charging apparatus is disclosed. The mobile charging apparatus includes a direct current electrical motor coupled to at least one wheel of a mobile equipment, the direct current electrical motor configured to generate an electrical power when the wheel is in motion and a battery contained in a compartment of the mobile equipment connected to a circuit connected to the direct current electrical motor and configured to receive the electrical power. The mobile charging apparatus further includes a charging port connected to the battery in a recessed area of the compartment, the charging port configured to receive power from the battery, the recessed area configured to receive an electronic device and the charging port includes a connector for charging the electronic device.

Abstract: This invention relates to a method of authenticating subscription to a mobile content service. Currently, the known methods of authenticating subscription to a mobile content service are unsatisfactory due to their susceptibility to fraud and their complexity. The present invention obviates the problems with the known methods by introducing a third party Unique Identifier verifier 7 (TPV). The TPV 7 generates a Unique Identifier code on request of a service provider 5 (SP) and transmits the Unique Identifier code to a mobile communication device 9 (MCD). The MCD 9 then transmits this Unique Identifier code to the SP 5 who in turn verifies the Unique Identifier code with the TPV 7. If the TPV 7 verifies that the Unique Identifier code is authentic, the MCD 9 user is subscribed to the service. This method simplifies the existing methods and furthermore reduces the possibility of fraud.

Abstract: This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with the result that a single target molecule becomes attached to a complex of many probe molecules. The structural modification involves fragmentation of the probe nucleic acid followed by joining the fragments together such that their order and orientation and number is altered from the original probe molecule. The result is the generation of permuted probe libraries. Probes made according to this invention can be used in many kinds of hybridization assays including Southern blots. Northern blots. Dot blots. Nucleic acid Array hybridization, ‘in situ’ hybridization with fluorescent or other labels (FISH) and various kinds of sandwich hybridization assays.

Abstract: A method of patient assessment, treatment, and outcome modeling is disclosed. The method includes obtaining patient characteristic information from a current patient, defining a plurality of therapeutic factors based on the characteristic information of the current patient, and weighting the therapeutic factors. The method also includes accessing at least one database having medical records of prior patients, the medical records including prior patient characteristic information, prior patient treatment plan, and prior patient outcome, comparing the weighted factors of the current patient to the medical records of the prior patients to identify one or more relevant prior patient records, and retrieving at least a portion of the relevant prior patient records, the portion including at least the prior patient treatment plan and the prior patient outcome.

Abstract: A new business method for acquiring and reselling new and used media or other similar items by creating a collection of network-accessible databases and computer scripts stored on a secure server and by connecting this server to machines that are distributed across a market geographically and function as vending and “reverse vending” points, and by further allowing access to other business entities such as owners and operators of the machines, and other business entities who are customarily involved in the wholesale or resale of the items purchased or sold throughout the machines, or other methods of procurement, and to laypersons who have presented items for sale to these reverse vending machines or other methods of procurement.

Abstract: This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with the result that a single target molecule becomes attached to a complex of many probe molecules. The structural modification involves fragmentation of the probe nucleic acid followed by joining the fragments together such that their order and orientation and number is altered from the original probe molecule. The result is the generation of permuted probe libraries. Various fragmentation and joining methods are described. Labeling can be done by standard methods before during or after formation of permuted probe libraries. Individual members of permuted probe libraries can be isolated and amplified and perpetuated.

Abstract: A method of patient assessment, treatment, and outcome modeling is disclosed. The method includes obtaining patient characteristic information from a current patient, defining a plurality of therapeutic factors based on the characteristic information of the current patient, and weighting the therapeutic factors. The method also includes accessing at least one database having medical records of prior patients, the medical records including prior patient characteristic information, prior patient treatment plan, and prior patient outcome, comparing the weighted factors of the current patient to the medical records of the prior patients to identify one or more relevant prior patient records, and retrieving at least a portion of the relevant prior patient records, the portion including at least the prior patient treatment plan and the prior patient outcome.

Abstract: This invention describes methods for generating nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with the result that a single target molecule becomes attached to a complex of many probe molecules. The structural modification involves fragmentation of the probe nucleic acid followed by joining the fragments together such that their order and orientation and number is altered from the original probe molecule. The result is the generation of permuted probe libraries. Individual members of permuted probe libraries can be isolated, amplified and perpetuated. Libraries can be prepared with additional sequences not present in the target and the fraction of the library made up by such sequences controlled.

Abstract: The present invention relates to a healthcare monitoring system and method that detects and transmits data. The system can utilize a wearable monitor that detects a variety of data from its wearer. The data can then be transmitted over a network to a centralized location where the data may be analyzed and any appropriate action may be taken.

Abstract: The present invention relates to a healthcare monitoring system and method that detects and transmits data. The system can utilize a wearable monitor that detects a variety of data from its wearer. The data can then be transmitted over a network to a centralized location where the data may be analyzed and any appropriate action may be taken.

Abstract: A pourer for improving the taste of water includes a base and a tubular member extending longitudinally through the base. A spout extends outwardly from the tubular member and at least two magnets disposed longitudinally along the tubular member are provided for exposing the water to a magnetic field as the water passes through the tubular member and spout.

Abstract: In a facility requiring transfer of a beverage during production thereof, the improvement includes a coupling apparatus passing bulk beverage therethrough and a having an outlet and an inlet along with a magnetic field generator associated with the coupling apparatus and exposing the beverage to the magnetic field as the beverage passes through the coupling.

Abstract: A method of treating an orally ingestible item having an original taste to be enhanced or reduced without imparting bitterness to the item, includes exposing the item to a magnetic field.