Abstract: In general, the present invention, and in various exemplary embodiments, provides a chemical management information system and methods of using the same. The chemical management system captures chemical use on an on-going and real-time basis regardless of the source of data. The chemical management system integrates chemical usage information by user input and from a plurality of sources. It also allows for the evaluation of a chemical in minutes rather than days, and further allows a user to submit this information to the governing body requiring the information in a simple step. In one embodiment, the chemical management system comprises a web-based use capture tool, a compliance tool, a safety database search tool, and a gap analysis tool.