Abstract: A biphasix multilayered lipid vesicle cannabinoid composition comprising: (a) a first phase comprising a first oil-in-water emulsion; and (b) a second phase suspended in the first phase, the second phase comprising multilamellar lipid vesicles, the multilamellar lipid vesicles entrapping a second oil-in-water emulsion, wherein at least one of the first and second oil-in-water emulsions comprises a therapeutically effective amount of a cannabinoid. The composition for transdermal and topical administration for the treatment of pain.

Abstract: A biphasix multilayered lipid vesicle cannabinoid composition comprising: (a) a first phase comprising a first oil-in-water emulsion; and (b) a second phase suspended in the first phase, the second phase comprising multilamellar lipid vesicles, the multilamellar lipid vesicles entrapping a second oil-in-water emulsion, wherein at least one of the first and second oil-in-water emulsions comprises a therapeutically effective amount of a cannabinoid. The composition for transdermal and topical administration for the treatment of pain.

Abstract: In an aspect of the invention, serotonin receptor antagonist formulations are provided for subcutaneous, transdermal or intradermal delivery to a subject. In an embodiment, serotonin receptor antagonist formulations include ondansetron or ondansetron-containing formulations. In another embodiment, serotonin receptor antagonist formulations include palonosetron or palonosetron-containing formulations. In another aspect of the invention, microinjection devices are provided for delivering a serotonin receptor antagonist formulation to a subject.

Abstract: A system for the administration of a bisphosphonate to a subject comprises a bisphosphonate formulation and a microinjection device. In an embodiment, the bisphosphonate formulation includes ibandronate sodium. In some cases, the bisphosphonate formulation includes an excipient. The bisphosphonate formulation may be delivered to the subject subcutaneously, transdermally or intradermally.

Abstract: The present application is directed to methods and systems for tapping online resources to design a clinical trial and/or recruit participants for the clinical trial. In one embodiment, a system for using online resources to design a clinical trial and/or recruit participants includes one or more web crawlers. Each of the web crawler may be configured to collect data related to one or more specified topics during a community identification phase. A data engine of the system processes the collected data into filtered, relevant information that identifies communities of individuals suitable for recruitment. A patient discovery module may, in a patient discovery phase, develop or use a survey to further target interested patients for recruitment and collect information for designing a suitable study or trial. The system may, in an assessment and communication phase, design a study which may be self-managed by the recruited patients.