Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.

Abstract: A hand movement controller is described which permits a variety of control functions to be performed by single left or right handed operation, and is particularly suitable for handicapped persons. The controller comprises a base which is generally wedge-shaped in side elevation with a sloping top surface on which is located a movable palm support on which the hand rests. One or two rows of keys are symmetrically spaced about the front edge of the palm support for engagement by the fingers of the hand. The distance between the movable palm support and keys is adjustable so that it can support the fingers to permit them to pivot freely about the knuckles with minimal strain over a prolonged period of time. The spacing of the row or rows of keys about the palm support is designed to optimize reaction time for fast operation. In a preferred embodiment an outer row of five keys and an inner row of three keys are used and permit control of movement in three dimensions.