Abstract: A cam phaser including a rotor; and a stator, wherein the rotor is rotatable relative to the stator, wherein a lobe of the rotor is arrangeable between two bars of the stator, wherein the lobe divides an intermediary space formed between the two bars into a first pressure cavity and a second pressure cavity, wherein a locking device including a spring loaded locking bolt and a locking disc is configured to lock the stator relative to the rotor in an end position, wherein the locking provides a locking clearance for moving the rotor relative to the stator, wherein the locking disc includes a contact element for adjusting the end position.

Abstract: A cam phaser including a rotor; and a stator, wherein the rotor is rotatable relative to the stator, wherein a lobe of the rotor is arrangeable between two bars of the stator, wherein the lobe divides an intermediary space formed between the two bars into a first pressure cavity and a second pressure cavity, wherein a locking device including a spring loaded locking bolt and a locking disc is configured to lock the stator relative to the rotor in an end position, wherein the locking provides a locking clearance for moving the rotor relative to the stator, wherein the locking disc includes a contact element for adjusting the end position.

Abstract: A hydraulic valve for oscillating-motor camshaft adjuster is provided. The valve has a bush and a hollow piston with a piston bottom. The piston is axially movable within the bush by means of an actuator against the force of a screw-type pressure spring. The actuator is applied to the piston bottom. A sleeve secured in the bush is disposed inside the hollow piston and can be displaced relative to the piston. The wall of this sleeve has at least one through-opening, which leads to at least one opening of the hollow piston, which opening can guide a supply pressure (P) applied inside the sleeve alternatively to two sets of pressure chambers of the oscillating-motor camshaft adjuster. The sleeve has a sleeve bottom that seals off the inside space of hollow piston.

Abstract: The invention relates to a hydraulic valve for oscillating-motor camshaft adjuster The valve has a bush and a hollow piston with a piston bottom. The piston is axially movable within the bush by means of an actuator against the force of a screw-type pressure spring. The actuator is applied to the piston bottom. A sleeve secured in the bush is disposed inside the hollow piston and can be displaced relative to the piston. The wall of this sleeve has at least one through-opening, which leads to at least one opening of the hollow piston, which opening can guide a supply pressure (P) applied inside the sleeve alternatively to two sets of pressure chambers of the oscillating-motor camshaft adjuster. The sleeve has a sleeve bottom that seals off the inside space of hollow piston.

Abstract: The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.

Abstract: The present invention is directed to compounds of formula (I): described as novel indolizine derivatives and to a method for their preparation along with pharmaceutical compositions thereof whose substituents are as described in the specification.

Abstract: The invention relates to benzofuran or benzothiophene derivatives, to processes for preparing them, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment of pathological syndromes of the cardiovascular system.

Abstract: The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicaments, in particular in the treatment of pathological syndromes of the cardiovascular system.

Abstract: Benzothiophenes and related compounds of formula (1), wherein A, B, Z are independently —CH═, —CR4═ or ═N—; X is —S—, —O—, —NH—, —NR2, —CH2—CH2—, CH2—CH2—CH2—, —CH2—O—; —OCH2—, —CH2—S—, —CO—, —SCH2—.

Abstract: The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula: 1

Abstract: The present invention relates to 2,2-dimethylchromene derivatives of the formula: ##STR1## in which Z represents a halogen atom or a cyano, nitro, acetyl, phosphono or dialkoxyphosohoryl group, the alkoxy group containing 1 to 3 carbon atoms, and the pharmaceutically acceptable salts of the phosphono group.These compounds show an antihypertensive and antiarrythmic activity.The present invention also relates to a process for the preparation of said compounds and to the pharmaceutical compositions in which the are present.

Abstract: The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CH.dbd.CH--E.dbd.CH-- or the group ##STR2## Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, alkylthio, carboxyl, phosphono, dial-koxyphosphoryl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms;E represents a nitrogen atom or a group C(R.sub.4);R.sub.1 represents hydrogen, a methyl group or a hydroxyl group and R.sub.2 and R.sub.3 each independently represent hydrogen or a methyl group, it being possible for only one of the substituents R.sub.1, R.sub.2 and R.sub.3 to be methyl; andR.sub.4 represents a hydrogen atom, a halogen atom, a methyl group or a hydroxyl group;and to the pharmaceutically acceptable salts of the phosphono or carboxyl group.These derivatives have an antiarrhythmic, antiasthma and antihypertensive activity.

Abstract: The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B=--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--;X=N, N.fwdarw.O, C-Z;R.sub.1 =H, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, OH, C.sub.1 -C.sub.4 alcoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --,.rho.--SO.sub.2 --;R.sub.2 =H;R.sub.3 =OH ou OCOCH.sub.3ou R.sub.2 +R.sub.3 =double bond.

Abstract: The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B.dbd.--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--; X.dbd.N,N.fwdarw.O, C--Z;R.sub.1 .dbd.H, CN, NO.sub.2, C.sub.1 -C.sub.4, alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .rho.--SO.sub.2 --;R.sub.2 .dbd.H;R.sub.3 .dbd.OH ou OCOCH.sub.3 ou R.sub.2 +R.sub.3 .dbd.double bond.

Abstract: The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarrhythmic activities. They respond to formula ##STR1## in which: A+B=--CH.dbd.CH--CH.dbd.N--or--CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--;X=N, N.fwdarw.O, C--Z;R.sub.1 =H, CN, NO.sub.2, C.sub.1 -C.sub.4 alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .phi.--SO.sub.2 --;R.sub.2 =H;R.sub.3 =OH or OCOCH.sub.3 or R.sub.2 +R.sub.3 =double bond.

Abstract: The present invention relates to derivatives of piperidinedione of formula: ##STR1## in which R is alkyl or forms with N a possibly substituted morpholino or piperidino group, n=2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent H or lower alkyl; R.sub.3 and R.sub.4 taken together may represent (CH.sub.2).sub.m where m=4 or 5 and R.sub.2 and R.sub.3 taken together may represent (CH.sub.2).sub.p where p=3 or 4 and in this case R.sub.1 and R.sub.4 =H, R.sub.5 is H or alkyl. It also relates to a process for manufacturing the product of formula (I) and to the drugs containing a product of formula (I).

Abstract: The present invention relates to the products of general formula: ##STR1## in which: R represents a straight or branched alkyl group having from 2 to 5 atoms of carbon, or the group ##STR2## represents a morpholino or piperidino group possibly substituted by 1 or 2 methyl groups;n=2 or 3;R.sub.1 and R.sub.2 considered independently each represent hydrogen or a lower alkyl group (1 to 4 carbon atoms) or R.sub.1 and R.sub.2 taken together represent a (CH.sub.2).sub.m group where m=4 or 5, R.sub.3 being equal to H or R.sub.1 is H and R.sub.2 and R.sub.3 considered together represent (CH.sub.2).sub.p where p is 3 or 4the butyrolactone cycle substitutes the pyridyl group in 2', 3' or 4' position,the salts, isomers and mixtures of isomers of said products; and to a process for preparing said products and to the myocardium-protecting drugs containing same.

Abstract: The present invention relates to derivatives of tryptamine of formula: ##STR1## in which: R.sub.1 represents a CH.sub.2 OH group, a --C.tbd.N group, ##STR2## or a --COOR.sub.6 group in which R.sub.4, R.sub.5 and R.sub.6 denote a lower alkyl group or hydrogen;R.sub.2 represents hydrogen or a C.tbd.N group;R.sub.3 denotes hydrogen, a CH.sub.3 group or a CH.sub.2 OH group, and the addition salts of the products of formula I with the pharmaceutically acceptable, mineral or organic acids. It also relates to a process for preparing said compounds and to the drugs active on the cardiovascular system, containing said compounds.

Abstract: The present invention relates to new derivatives of pyrrole of formula: ##STR1## in which: R.sub.1 represents an atom of hydrogen, a lower alkyl group, a phenyl radical or a pyridyl-2 radical,R.sub.2 represents an atom of hydrogen or a lower alkyl radicalR.sub.3 and R.sub.4 represent a lower alkyl or cycloalkyl radical or the radical ##STR2## is a heterocyclic amine radical, and n is equal to 2 or 3;The invention concerns drugs having an antiarrhythmic activity and an activity as blood platelet anti-aggregant, containing said derivatives.