Abstract: The invention pertains to a method for preventing or treating SARS-CoV-2 infection by administering SARS-CoV-2 specific T cells which recognize particular peptide epitopes in SARS-CoV-2 spike (S), nucleocapsid (N), membrane, and envelope proteins.

Abstract: A node includes a processor coupled to a wireless transceiver and a memory. The memory includes instructions that can cause the processor to store a broadcast channel hopping timing interval and a broadcast channel hopping sequence, as well as, channel hopping timings and channel hopping sequences for tracked neighbor nodes. The instructions can also cause the processor to determine whether a destination node for a unicast message corresponds to tracked neighbor nodes. Based on a determination that the destination node does not correspond to any tracked neighbor nodes, the processor can determine (i) a broadcast dwell interval based on the broadcast channel hopping timing interval and (ii) a next broadcast channel based on the broadcast channel hopping sequence. Additionally, instructions can cause the processor to transmit the unicast message to the destination node during the broadcast dwell interval.

Abstract: A deployed node may automatically switch from one configuration to another configuration. The node includes a first firmware image that corresponds to a first configuration and a second firmware image that corresponds to a second configuration. The node executes the first firmware image to run the first configuration. At some point, the node determines that a switch to the second configuration is appropriate and switches to the second configuration by activating the second firmware image. The switch does not require intervention by a central system or any manual intervention. In some instances, the configurations are associated with different communication protocols.

Abstract: The invention pertains to a method for treating a cancer which expresses PRAME using T cells which recognize specific peptide epitopes of PRAME, to a method for producing T cells that target cancer cells expressing PRAME, the peptide epitopes of PRAME themselves and to compositions and methods of treatment using these peptides.

Abstract: Systems and methods are disclosed for facilitating communications in heterogeneous networks that include different data networks. A gateway device is configured to communicate with a first network using a TSCH protocol and with a second network using a channel hopping CSMA protocol. The gateway device can determine, during a first part of a TSCH timeslot, whether a message is received from the first network. If no message is received, the gateway device switches to the second network during a second part of the timeslot. If the gateway device receives a message from the second network, the gateway device may continue to receive the message. The receipt of the message in the second network may continue into a subsequent TSCH timeslot or may be interrupted if certain conditions are met.

Abstract: A multi-radio border router for synchronizing communications of multiple border router radios is provided. For example, the border router includes a border router component connected to each of the plurality of border router radios. The border router component configured for selecting one of the plurality of border router radios as a master radio and assigning channel offset parameters for each of the plurality of border router radios. The master radio is configured for broadcasting synchronization beacons based on which the non-master radios synchronize their respective clocks with that of the master radio. After the synchronization, each of the border router radios communicates with endpoints associated therewith according to a channel hopping pattern modified by applying a channel offset determined based on the channel offset parameters assigned to the respective radio.

Abstract: Disclosed are compositions of cells, libraries of such cells and methods of making T cell populations for treatment of disorders such as cancer and viral infections. T cell composition comprise cell subpopulations stimulated, in some embodiments, with FRAME, survivin and/or WT1.

Abstract: A node includes a processor coupled to a wireless transceiver and a memory. The memory includes instructions that can cause the processor to store a broadcast channel hopping timing interval and a broadcast channel hopping sequence, as well as, channel hopping timings and channel hopping sequences for tracked neighbor nodes. The instructions can also cause the processor to determine whether a destination node for a unicast message corresponds to tracked neighbor nodes. Based on a determination that the destination node does not correspond to any tracked neighbor nodes, the processor can determine (i) a broadcast dwell interval based on the broadcast channel hopping timing interval and (ii) a next broadcast channel based on the broadcast channel hopping sequence. Additionally, instructions can cause the processor to transmit the unicast message to the destination node during the broadcast dwell interval.

Abstract: A multi-radio border router for synchronizing communications of multiple border router radios is provided. For example, the border router includes a border router component connected to each of the plurality of border router radios. The border router component configured for selecting one of the plurality of border router radios as a master radio and assigning channel offset parameters for each of the plurality of border router radios. The master radio is configured for broadcasting synchronization beacons based on which the non-master radios synchronize their respective clocks with that of the master radio. After the synchronization, each of the border router radios communicates with endpoints associated therewith according to a channel hopping pattern modified by applying a channel offset determined based on the channel offset parameters assigned to the respective radio.

Abstract: Systems and methods are disclosed for reconstructing a personal area network (“PAN”) after a failure in a system or network. A method can include detecting, by a node, a power failure in a system. The method can further include storing, by the node, data about a parent node in the system at a time of the power failure. The method can further include detecting, by the node, power restoration in the system and entering a restoration state in response to detecting the power restoration. The method can further include transmitting, by the node and to the parent node, an enhanced beacon request via a particular frequency channel associated with the parent node. The method can also include receiving, by the node, an acknowledgment response from the parent node via the frequency channel and receiving, by the node, an enhanced beacon request from the parent node via the frequency channel.

Abstract: A deployed node may automatically switch from one configuration to another configuration. The node includes a first firmware image that corresponds to a first configuration and a second firmware image that corresponds to a second configuration. The node executes the first firmware image to run the first configuration. At some point, the node determines that a switch to the second configuration is appropriate and switches to the second configuration by activating the second firmware image. The switch does not require intervention by a central system or any manual intervention. In some instances, the configurations are associated with different communication protocols.

Abstract: A multi-radio border router for synchronizing communications of multiple border router radios is provided. For example, the border router includes a border router component connected to each of the plurality of border router radios. The border router component configured for selecting one of the plurality of border router radios as a master radio and assigning channel offset parameters for each of the plurality of border router radios. The master radio is configured for broadcasting synchronization beacons based on which the non-master radios synchronize their respective clocks with that of the master radio. After the synchronization, each of the border router radios communicates with endpoints associated therewith according to a channel hopping pattern modified by applying a channel offset determined based on the channel offset parameters assigned to the respective radio.

Abstract: The present disclosure relates to thermal management of wireless access points including local thermal management, cloud-based thermal management, and thermal management based on optimization and operation such as in a distributed Wi-Fi network. The objective of the present disclosure is for thermal management in access points allowing small form-factors and aesthetic designs, preventing overheating and without requiring reduced performance or reduced hardware. Generally, the systems and methods detect when access points are nearing overheating and alter their operation so as to minimize the reduction of performance in the network while reducing power consumption.

Abstract: The disclosure relates to methods of culturing and expanding CD4+ and/or CD8+ T cells in culture. In some embodiments, the methods include expanding, proliferating and storing lymphocytes in tissue culture by exposing the lymphocytes to a combination of cytokines and/or nucleic acids expressing cytokines or functional fragments or variants thereof. The disclosure further relates to methods of generating and manufacturing CD4+ and/or CD8+ T cells that are specific to one or a plurality of viral antigens.

Abstract: Provided herein are activated adoptive T-cell compositions targeting plasma cell dyscrasias such as multiple myeloma and methods of treating plasma cell dyscrasias such as multiple myeloma using such compositions. The T-cell compositions of the present disclosure are activated against a select group of antigens associated with multiple myeloma (MMAAs) and, in certain embodiments, in combination with more widely expressed tumor associated antigens (TAAs). In particular, the T-cell compositions of the present disclosure are directed to the MMAAs selected from B-cell maturation antigen (BCMA), X box Protein 1 (XBP1), CS1, and Syndecan-1 (CD 138), or a combination thereof. In certain embodiments, the T-cell composition includes T-cells activated to a TAA selected from preferentially expressed antigen of melanoma (PRAME), Survivin, Wilms' Tumor 1 protein (WT1), and melanoma antigen 3 (MAGE-A3), or a combination thereof.

Abstract: The disclosure provides T-cell compositions, therapies and processes of manufacture that are tailored to the specific antigenic expression of a subjects' tumor and allowing for changes in expression over time based on either pressure from antineoplastic therapy or natural heterogeneous selection. The disclosure also extends to methods of manufacturing such T-cell compositions and the generation of single antigen T-cell banks from healthy donors to provide an improved personalized T-cell therapy.

Abstract: Safe, rapid, and efficient methods for producing antigen-specific T cells recognizing human papilloma virus (HPV antigens); HPV-specific T cells, and methods for treating HPV infections and HPV-related malignancies by adoptive transfer of HPV-specific T cells.

Abstract: The present disclosure relates, at least in part, to a closed and semi-automated system for the isolation of naive T cells, their expansion, and/or final harvest. The disclosure also relates to using those isolated cells in a large batch format for compiling stocks of stimulated CD45A+ T cells and/or using the stimulated CD45A+ T cells for therapeutic purposes.

Abstract: A multi-radio border router for synchronizing communications of multiple border router radios is provided. For example, the border router includes a border router component connected to each of the plurality of border router radios. The border router component configured for selecting one of the plurality of border router radios as a master radio and assigning channel offset parameters for each of the plurality of border router radios. The master radio is configured for broadcasting synchronization beacons based on which the non-master radios synchronize their respective clocks with that of the master radio. After the synchronization, each of the border router radios communicates with endpoints associated therewith according to a channel hopping pattern modified by applying a channel offset determined based on the channel offset parameters assigned to the respective radio.

Abstract: Systems and methods are disclosed for facilitating communications in heterogeneous networks that include different data networks. A gateway device is configured to communicate with a first network using a TSCH protocol and with a second network using a channel hopping CSMA protocol. The gateway device can determine, during a first part of a TSCH timeslot, whether a message is received from the first network. If no message is received, the gateway device switches to the second network during a second part of the timeslot. If the gateway device receives a message from the second network, the gateway device may continue to receive the message. The receipt of the message in the second network may continue into a subsequent TSCH timeslot or may be interrupted if certain conditions are met.