Patents by Inventor Patrick Hof
Patrick Hof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9670520Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: GrantFiled: May 2, 2016Date of Patent: June 6, 2017Assignee: Patheon Holdings | B.V.Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Publication number: 20170057987Abstract: The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.Type: ApplicationFiled: April 5, 2016Publication date: March 2, 2017Inventors: Johannes Gernardus Mathias Marie Van Bree, Everardus Joannes Peter Maria Schenkelaars, Jouwert Anne Turkstra, Maria Aldegonda Jacoba Kriek, Robert Patrick Hof, Wilhelmus Martinus Maria Schaaper
-
Patent number: 9469865Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cells culture comprising the cells, the biological substance and the cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: GrantFiled: February 7, 2014Date of Patent: October 18, 2016Assignee: DPX Holdings B.V.Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Publication number: 20160265017Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: ApplicationFiled: May 2, 2016Publication date: September 15, 2016Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Patent number: 9327020Abstract: The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.Type: GrantFiled: June 3, 2011Date of Patent: May 3, 2016Assignee: Immunovo B.V.Inventors: Johannes Gernardus Mathias Marie Van Bree, Everardus Joannes Peter Maria Schenkelaars, Jouwert Anne Turkstra, Maria Aldegonda Jacoba Kriek, Robert Patrick Hof, Wilhelmus Martinus Maria Schaaper
-
Publication number: 20130273082Abstract: The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.Type: ApplicationFiled: June 3, 2011Publication date: October 17, 2013Applicant: IMMUNOVO B.V.Inventors: Johannes Gernardus Mathias Marie Van Bree, Everardus Joannes Peter Maria Schenkelaars, Jouwert Anne Turkstra, Maria Aldegonda Jacoba Kriek, Robert Patrick Hof, Wilhelmus Martinus Maria Schaaper
-
Publication number: 20120149107Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: ApplicationFiled: February 15, 2012Publication date: June 14, 2012Applicant: DSM IP ASSETS B.V.Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Publication number: 20120149063Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: ApplicationFiled: February 13, 2012Publication date: June 14, 2012Applicant: DSM IP ASSETS B.V.Inventors: Gerben Meile ZIJLSTRA, Robert Patrick HOF, Jacobs SCHILDER
-
Publication number: 20120064623Abstract: The invention relates to a process for the culturing of cells, preferably El-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: ApplicationFiled: October 25, 2011Publication date: March 15, 2012Applicant: DSM IP ASSETS B.V.Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Patent number: 8119368Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: GrantFiled: July 4, 2007Date of Patent: February 21, 2012Assignee: DSM IP Assets B.V.Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Patent number: 7718812Abstract: The invention relates to a process for the conversion of group X in a 2-(6-substituted)-1,3-dioxane-4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylating agent, by using as a phase transfer catalyst a quarternary phosphonium ion and by using as an oxylating agent an OY-ion. X stands for a halogen and R1, R2 and R3 are each independently a C1–4 alkylgroup or R1 and R2 together with the C-atom to which they are bound form a 5- or 6-membered cycloalkyl; Y stands for RA-CO— or for RB—SO2- with RA, RB are chosen from the group of alkyl or aryl with 1–12 C-atoms.Type: GrantFiled: December 9, 2002Date of Patent: May 18, 2010Assignee: AstraZeneca UK LimitedInventor: Robert Patrick Hof
-
Publication number: 20100075413Abstract: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to the cell culture and wherein the cell culture comprising the cells, the biological substance and cell culture medium is circulated over a separation system and wherein the separation system separates the biological substance from substances having a lower molecular weight than the biological substance and wherein the biological substance is retained in or fed back into the reactor. Preferably part of the substances of lower molecular weight is continuously removed from the cell culture.Type: ApplicationFiled: July 4, 2007Publication date: March 25, 2010Inventors: Gerben Meile Zijlstra, Robert Patrick Hof, Jacob Schilder
-
Patent number: 7490438Abstract: The invention relates to a motor vehicle door, consisting of an interior sheet metal and an exterior sheeting, together which form a hollow interior space of the door, having an opening in the interior sheet metal and having a carrier module that closes said opening, and carries at least one functional part of the motor vehicle door, such as a hinge part, lock part or window lifter part. In order to simplify the assembly of a motor vehicle door it is proposed that the vehicle door (10) features, apart from the opening (18) in the interior sheet metal (12) which may be closed by means of a carrier module, an additional access opening (22) adequately large for inserting the carrier module, including the at least one functional part, into the interior space (16) of the door and that the carrier module consists of a base plate (20) which closes the opening (18) of the interior sheet metal (12) from the side of the hollow interior space (16) of the door.Type: GrantFiled: September 28, 2000Date of Patent: February 17, 2009Assignee: Meritor Automotive GmbHInventors: Klaus-Peter Maass, Uwe Bergmann, Arnd G. Herwig, Stefan Jutzi, Patrice Cardine, Rainer Grimm, Harald Kollner, Klaus-Dieter Strauss, Georg Wurm, Daniel Drewniok, Patrick Hof, Simon Blair Dobson, Gregory Keyes, Kenneth W. Schang
-
Patent number: 7231717Abstract: A method of assembling of a door comprising the steps of providing a door inner panel having an outer face and an inner face, at least one functional component of the door, an anti intrusion beam and a door outer panel. The functional component is assembled onto and towards the outer face. The anti intrusion beam is assembled towards the outer face prior to assembling the door outer panel towards the outer face. Fixing means secure the door inner panel, the functional component, the anti intrusion beam and the door outer panel relative to each other.Type: GrantFiled: December 13, 2001Date of Patent: June 19, 2007Assignee: Meritor Light Vehicle Systems - FranceInventors: Georg Wurm, Daniel Drewniok, Harald Koellner, Klaus Dieter Strauss, Kenneth W. Schang, Arnd Herwig, Simon Blair Dobson, Rainer W. Grimm, Gregory Keyes, Patrick Hof
-
Patent number: 6929307Abstract: Hollow-interior vehicle door consisting of an internal in its entirety essentially pot-shaped or pan-shaped stiffening structure, and of at least one external outer panel element being essentially lid-shaped and supported by the essentially pot-shaped or pan-shaped stiffening structure, such as a door skin, as well as of functional parts for practicing the door functions, and of optionally an inner panel element, in which the essentially pot-shaped or pan-shaped stiffening structure serves to accommodate functional parts of the vehicle door.Type: GrantFiled: September 28, 2000Date of Patent: August 16, 2005Assignee: ArvinMeritor GmbHInventors: Rainer Grimm, Harald Kollner, Klaus-Dieter Strauss, Georg Wurm, Daniel Drewniok, Arnd G. Herwig, Patrick Hof, Simon Blair Dobson, Klaus-Peter Maass, Kenneth W. Schang
-
Patent number: 6846955Abstract: The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is conducted in an organic solvent. Preferably a metal alkoxide, a metal alkyl, a metal amide, or a metal hydride, in particular a metal alkoxide is applied as the strong base. As the Schiff base preferably N-benzylidene primary amino acid amide is used, with the primary amino acid amide preferably being derived from an aliphatic primary amino acid amide, for example tertiary-leucine amide. As organic solvent use is preferably made of an aromatic hydrocarbon, a cyclic, aliphatic hydrocarbon or a ether, in particular an aromatic hydrocarbon is applied. The invention may also be applied for the racemisation of an enantiomer-enriched primary amino acid amide.Type: GrantFiled: June 22, 2001Date of Patent: January 25, 2005Assignee: DSM N.V.Inventors: Robert Patrick Hof, Petrus Johannes Hermsen, Ronus de Bode
-
Patent number: 6586634Abstract: Process for the preparation of (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate, in which in a solvent a mixture of enantiomers of cis-1-amino-2-indanol reacts at an elevated temperature with (R,R)-tartaric acid and methanol and in which optically enriched (1S,2R)-1-amino-2-indanol-(R,R)-tartrate methanol solvate crystallizes out, after which the crystals are recovered, the recovery taking place at a temperature between 10 and 50° C. in the presence of 0-20 wt. % water relative to the amount of methanol plus solvent, on the understanding that if the reaction mixture is essentially free from water the recovery substantially takes place at a temperature between 30 and 50° C. Preferably the reactants are at least in part contacted with each other at an elevated temperature and only methanol is used as solvent. Preferably the amount of (1S,2R)-1-amino-2-indanol applied is between 0.02 and 0.1 g per ml of solvent.Type: GrantFiled: June 12, 1998Date of Patent: July 1, 2003Assignee: DSM N.V.Inventor: Robert Patrick Hof
-
Patent number: 6536832Abstract: A motor vehicle door includes structural parts for providing the rigidness of the vehicle door and includes a structural element and a lining element. The door further includes function components for providing vehicle door functions like a window panel with a regulator. At least one of the structural parts serves as a support of the function components. In order to reduce the number of individual components, at least one of the structural parts forms a completely shaped composite or sandwich part having a plastic based matrix and further having several of the function components included to serve a rigidness providing bodies. The bodies are molded into the plastic based matrix by the plastic based matrix.Type: GrantFiled: September 28, 2000Date of Patent: March 25, 2003Assignee: Arvin Meritor GmbHInventors: Rainer Grimm, Klaus-Dieter Strauss, Daniel Drewniok, Harald Kollner, Georg Wurm, Arnd G. Herwig, Patrick Hof, Simon Blair Dobson, Gregory Keyes, Kenneth W. Schang
-
Publication number: 20020162208Abstract: A method of assembling of a door comprising the steps of providing a door inner panel having an outer face and an inner face, at least one functional component of the door, an anti intrusion beam and a door outer panel. The functional component is assembled onto and towards the outer face. The anti intrusion beam is assembled towards the outer face prior to assembling the door outer panel towards the outer face. Fixing means secure the door inner panel, the functional component, the anti intrusion beam and the door outer panel relative to each other.Type: ApplicationFiled: December 13, 2001Publication date: November 7, 2002Inventors: Georg Wurm, Daniel Drewniok, Harald Koellner, Klaus Dieter Strauss, Kenneth W. Schang, Arnd Herwig, Simon Blair Dobson, Rainer W. Grimm, Gregory Keyes, Patrick Hof
-
Publication number: 20010056209Abstract: The invention relates to a process for racemising an enantiomer-enriched Schiff base of a primary amino acid amide with a strong base that is chemically reactive towards water. The reaction is conducted in an organic solvent. Preferably a metal alkoxide, a metal alkyl, a metal amide, or a metal hydride, in particular a metal alkoxide is applied as the strong base. As the Schiff base preferably N-benzylidene primary amino acid amide is used, with the primary amino acid amide preferably being derived from an aliphatic primary amino acid amide, for example tertiary-leucine amide. As organic solvent use is preferably made of an aromatic hydrocarbon, a cyclic, aliphatic hydrocarbon or a ether, in particular an aromatic hydrocarbon is applied. The invention may also be applied for the racemisation of an enantiomer-enriched primary amino acid amide.Type: ApplicationFiled: June 22, 2001Publication date: December 27, 2001Inventors: Robert Patrick Hof, Petrus Johannes Hermsen, Ronus De Bode