Patents by Inventor Patrick Holder

Patrick Holder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PD-1 targeted IL-15/IL-15R? Fc fusion proteins with improved properties
    Patent number: 11932675
    Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: March 19, 2024
    Assignees: GENENTECH, INC., XENCOR, INC.
    Inventors: John Desjarlais, Matthew Bernett, Michael Hedvat, Rajat Varma, Suzanne Schubbert, Christine Bonzon, Rumana Rashid, Juan Diaz, Patrick Holder, Christine Huang
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20230357814
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: April 7, 2023
    Publication date: November 9, 2023
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated formylglycine-generating enzymes and methods of producing and using the same
    Patent number: 11655492
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: May 23, 2023
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20220002775
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: June 2, 2021
    Publication date: January 6, 2022
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • PD-1 TARGETED IL-15/IL-15RALPHA FC FUSION PROTEINS WITH IMPROVED PROPERTIES
    Publication number: 20210230243
    Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
    Type: Application
    Filed: October 9, 2020
    Publication date: July 29, 2021
    Inventors: John Desjarlais, Matthew Bernett, Michael Hedvat, Rajat Varma, Suzanne Schubbert, Christine Bonzon, Rumana Rashid, Juan Diaz, Patrick Holder, Christine Huang
  • Activated formylglycine-generating enzymes and methods of producing and using the same
    Patent number: 11053529
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: July 6, 2021
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20200370084
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: May 4, 2020
    Publication date: November 26, 2020
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated formylglycine-generating enzymes and methods of producing and using the same
    Patent number: 10683527
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 16, 2020
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20190390240
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: May 16, 2019
    Publication date: December 26, 2019
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated formylglycine-generating enzymes and methods of producing and using the same
    Patent number: 10344311
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: July 9, 2019
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20180223322
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: January 4, 2018
    Publication date: August 9, 2018
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated formylglycine-generating enzymes and methods of producing and using the same
    Patent number: 9951367
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: April 24, 2018
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker
  • Activated Formylglycine-Generating Enzymes and Methods of Producing and Using the Same
    Publication number: 20160230205
    Abstract: The present disclosure provides activated formylglycine-generating enzymes (FGE), methods of producing activated FGE, and their use in methods of producing a protein comprising a formylglycine (FGly) residue. The methods of producing activated FGE, as well as methods of use of activated FGE in producing FGly-containing proteins, include both cell-based and cell-free methods. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure are also provided.
    Type: Application
    Filed: December 18, 2015
    Publication date: August 11, 2016
    Inventors: David Rabuka, Gregory W. deHart, Patrick Holder, Jeanne Baker