Patents by Inventor Patrick Hossler

Patrick Hossler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES
    Publication number: 20190185897
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Ivan Correia
  • METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING SUGARS
    Publication number: 20170355760
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
    Type: Application
    Filed: May 5, 2017
    Publication date: December 14, 2017
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Joseph G. Matuck, Keith Cochran, Christopher M. Chumsae
  • MAMMALIAN CELL CULTURE PERFORMANCE THROUGH SURFACTANT SUPPLEMENTATION OF FEED MEDIA
    Publication number: 20170247445
    Abstract: The present invention provides methods for increasing cell culture performance through the use of chemically defined feed media (CDFM). In particular, the present invention provides methods for the use of surfactants as supplements to CDFM to allow for higher concentrations of media components and thereby result in increased cell culture performance.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 31, 2017
    Inventors: Sean McDermott, Patrick Hossler
  • METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING COBALT
    Publication number: 20170226552
    Abstract: The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.
    Type: Application
    Filed: July 1, 2015
    Publication date: August 10, 2017
    Inventors: Patrick Hossler, Christopher Racicot, Sean McDermott
  • METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES
    Publication number: 20170137860
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 18, 2017
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Ivan Correia
  • METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS
    Publication number: 20170051052
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g.
    Type: Application
    Filed: November 8, 2016
    Publication date: February 23, 2017
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9505834
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: November 29, 2016
    Assignee: AbbVie Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
    Patent number: 9499614
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 22, 2016
    Assignee: AbbVie Inc.
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Ivan Correia
  • METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS
    Publication number: 20160207992
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g.
    Type: Application
    Filed: March 31, 2016
    Publication date: July 21, 2016
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING SUGARS
    Publication number: 20160185848
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.
    Type: Application
    Filed: July 9, 2015
    Publication date: June 30, 2016
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Joseph G. Matuck, Keith Cochran, Chris M. Chumsae
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9365645
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: June 14, 2016
    Assignee: AbbVie, Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS
    Publication number: 20160152702
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9255143
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: February 9, 2016
    Assignee: AbbVie Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9090688
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: July 28, 2015
    Assignee: AbbVie Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • Efficient and effective supplement screening for the development of chemically defined media in cell culture
    Patent number: 9068970
    Abstract: The present invention relates to methods of selecting and developing a chemically defined media (“CDM”) for use in the manufacture of biological products. In particular, the present invention is directed to screening methods to determine cell culture technique media supplement blends with enhanced performance characteristics. The present invention is also directed to identifying CDM supplement blends that demonstrate significant increases in harvest titer and/or viable cell density.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: June 30, 2015
    Assignee: Abbvie Inc.
    Inventors: Patrick Hossler, Christopher Racicot, Sean McDermott, John C. Fann
  • Methods for controlling the galactosylation profile of recombinantly-expressed proteins
    Patent number: 9062106
    Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: June 23, 2015
    Assignee: AbbVie Inc.
    Inventors: Cornelia Bengea, Lisa M. Rives, Patrick Hossler
  • METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES
    Publication number: 20140271632
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: AbbVie, Inc.
    Inventors: Patrick Hossler, Sean McDermott, Christopher Racicot, Ivan Correia
  • MAMMALIAN CELL CULTURE PERFORMANCE THROUGH SURFACTANT SUPPLEMENTATION OF FEED MEDIA
    Publication number: 20140271633
    Abstract: The present invention provides methods for increasing cell culture performance through the use of chemically defined feed media (CDFM). In particular, the present invention provides methods for the use of surfactants as supplements to CDFM to allow for higher concentrations of media components and thereby result in increased cell culture performance.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: ABBVIE INC.
    Inventor: Patrick Hossler
  • Secretory Protein Biomarkers For High Efficiency Protein Expression
    Publication number: 20140004531
    Abstract: The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: ABBVIE INC.
    Inventors: Patrick Hossler, Ivan Correia
  • Secretory protein biomarkers for high efficiency protein expression
    Patent number: 8524458
    Abstract: The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: September 3, 2013
    Assignee: Abbvie Inc.
    Inventors: Patrick Hossler, Ivan Correia