Abstract: The present invention relates to compounds selected from the group consisting of: (i) the compounds of the formula  in which X is a halogen atom, A is a group —NH—(CH2)n—NH—CO—, —NH—CH2— or Q is a group R1 is hydrogen, halogen, C1-C3 alkyl or C1-C5 1-oxoalkyl, R2 is H or OH and n is 2, 3 or 4; and (ii) their addition salts. It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.

Abstract: This invention relates to compounds of the formula where X is halogen, R1 is H or a C1-C3 alkyl, R2 is H or OH and R3 is one of in which A is a single bond or a —CO(CH2)p—NH— group, R4 is H or —C(═NR5)NHR′5, R5 and R′5 are each H or a C1-C6 alkyl group, R6 is H or a C1-C3 alkyl group, m is 0, 1 or 2; n is 2, 3 or 4; p is 1, 2 or 3; plus their acid addition salts. The invention likewise relates to the method for their preparation and their therapeutic applications.

Abstract: The present invention relates to compounds selected from the group consisting of the compounds of formula (I): ##STR1## X is a halogen atom, A is --CH.sub.2 --, --CH(OH)--, --CH(NH--COCH.sub.3)-- or S, R is H, CO.sub.2 H, CO.sub.2 --B--R.sub.1 or CO--N(R.sub.2)--B--R.sub.1, B is linear, branched or cyclic C.sub.1 -C.sub.10 -alkylene, R.sub.1 is H, CH.sub.2 OH, CH.sub.2 --O--CH.sub.3, CH.sub.2 --NR.sub.3 R.sub.4 or phenyl, R.sub.2 is H or C.sub.1 -C.sub.4 -alkyl, R.sub.3 is H or linear, branched or cyclic C.sub.1 -C.sub.10 -alkyl, R.sub.4 is H or linear or branched C.sub.1 -C.sub.10 -alkyl, it being possible for NR.sub.3 R.sub.4 to be a saturated heterocyclic radical having from 5 to 8 ring members and containing at least one nitrogen atom, and the carbon carrying the substituent R, when Q is saturated, can be of indeterminate (R,S) configuration or of determinate (R) or (S) configuration; and their addition salts.

Abstract: Compounds selected from the group which consists of the compounds of formula (I), ##STR1## wherein each of X.sub.1 and X.sub.2 which are the same or different, is halogen or a C.sub.1-3 alkoxy group, R.sub.1 is H, CF.sub.3 or a C.sub.1-3 alkyl group, R.sub.2 is a hydrogen atom or an OH group, A is group (a), (b) or (c), B is a single bond, --CO--, --CO--CH.sub.2 --, --CO--CH.sub.2 --O--, --CO--CH.dbd.CH or --SO.sub.2 --, m is 2 or 3, N is 0, 1, 2 or 3, R.sub.3 is a hydrogen atom or a methyl group and W is CH or N, the amidine group C(.dbd.NR.sub.2)NH.sub.2 being in the 2, 3 or 4 position on the aromatic ring, and addition salts thereof, are disclosed. A method for preparing said compounds, and the therapeutical use thereof, particularly for treating diseases in which bradykinin is involved, are also disclosed.

Abstract: The present invention relates to compounds selected from the group consisting of(i) the compounds of formula I: ##STR1## in which: X is a halogen atom or a methyl group,A is a group --N(R.sub.3)CO-- or --CO--N(R.sub.3)--,B is a single bond, --CH.sub.2 -- or --CH.sub.2 --O--,R.sub.1 is H, a C.sub.1 -C.sub.3 alkyl group or a CF.sub.3 group,R.sub.2 and R.sub.3 are each independently H or a C.sub.1 -C.sub.3 alkyl group,W is CH or N, andn is 2, 3, 4 or 5; and(ii) their addition salts.It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.

Abstract: The present invention relates to novel compounds of the formula in which:X is a halogen atom,R.sub.1 and R.sub.2, which are identical or different, are each --H or --A--B--R.sub.3,A is a linear or branched C.sub.1 -C.sub.12 -alkylene chain,B is a single bond, a divalent phenylene group or a divalent indolyl group of the structure ##STR1## R.sub.3 is --H, --OH, --NR.sub.4 R.sub.5 or --COR.sub.6, R.sub.6 is --OH, --OCH.sub.3, --OC.sub.2 H.sub.5 or --NR.sub.4 R.sub.5,R.sub.4 and R.sub.5, which are identical or different, are each H, a C.sub.1 -C.sub.4 -alkyl group, --(CH.sub.2).sub.n --OH, --(CH.sub.2).sub.n --N(CH.sub.3).sub.2 or --CO--CH.sub.3, andn is an integer with a value of 2, 3 or 4; and their addition salts. It further relates to their preparation and to their use in therapeutics, especially for the treatment of pathological conditions involving bradykinin.

Abstract: The present invention relates to novel 4-methylthiazole derivatives, to tr methods of preparation and to the pharmaceutical compositions in which they are present.According to the invention, these derivatives have the general formula ##STR1## in which n is equal to 0 or 1 and R.sub.1 and R.sub.2, which are identical or different, are selected from a hydrogen atom, a halogen, a hydroxyl group, a trifluoromethyl group, an alkyl group having from 1 to 4 carbon atoms and an alkoxy group having from 1 to 5 carbon atoms and are useful in the treatment of cardiovascular diseases associated with hyperactivity of the sympathetic nervous system.

Abstract: The present invention relates to novel 4-methyl-5-[2-(4-phenylpiperazin-1-yl)ethyl]thiazole derivatives of the general formula ##STR1## in which R is selected from a hydrogen atom, an alkyl radical having from 2 to 7 carbon atoms and an aralkyl radical of which the aryl moiety preferably consists of phenyl and of which the alkyl moiety has from 1 to 4 carbon atoms, and to the pharmaceutically acceptable salts of these derivatives.It further relates to a method of preparing these products and to pharmaceutical compositions in which they are incorporated.These derivatives are applied especially in the preparation of drugs intended for the treatment of functional dysuria associated with hyperactivity of the .alpha.-adrenergic sympathetic nervous system.

Abstract: The present invention relates to the products of general formula (I): ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are selected om a hydrogen atom, a halogen atom, a hydroxyl radical, an alkyl radical having from 1 to 5 (sic) carbon atoms, an alkoxy radical having from 1 to 5 carbon atoms or a phenoxy, benzyloxy, trifluoromethyl or acetyl radical.It further relates toa method of preparing said productsand the drugs in which said products are present.

Abstract: The present invention relates, by way of novel industrial products, to the ollowing oxyimino derivatives of thiazole: (a) the E and Z diastereoisomers of the formula ##STR1## in which R.sub.1 represents H, F, Cl, Br, CF.sub.3 or CH.sub.3 and R.sub.2 represents a C.sub.1 -C.sub.10 -alkyl group, a benzyl group of the formula CH.sub.2 C.sub.6 H.sub.2 (R.sub.3).sub.3, in which each R.sub.3 identical or different represents H, F,Cl,Br, CF.sub.3, a C.sub.1 -C.sub.4 -alkyl group or a C.sub.1 -C.sub.4 -alkoxy group, a group CH.sub.2 COOR.sub.4, in which R.sub.4 represents H, a C.sub.1 -C.sub.4 -alkyl group or the ammonium group, NH.sub.4.sup.+, a group CH.sub.2 COOM.sub.m, in which M is an alkali metal or alkaline earth metal and m is its valency, or a 2-aminoethyl group of the formula CH.sub.2 CH.sub.2 NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which can be identical or different each represent H or a C.sub.1 -C.sub.4 -alkyl group, it being possible for R.sub.5 and R.sub.

Abstract: The present invention relates to novel products of the formula: ##STR1## in which R is selected from the group comprising H, OH, --O--COCH.sub.3 and --O--CO--(CH.sub.2).sub.n --CH.sub.3, in which n is between 1 and 8, and the salts of the products of the formula (I) with pharmaceutically acceptable acids.