Patents by Inventor Patrick Hubert J. Nieste

Patrick Hubert J. Nieste has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20170239256
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-di hydroquinazolin-5-yl)-N, N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Applicant: Respivert Limited
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Crystalline 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-0X0-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide
    Patent number: 9642799
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: May 9, 2017
    Assignee: Respivert, Ltd.
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • Preparation of 13-Cyclohexyl-3-Methoxy-6-[Methyl-(2-(2-[Methyl-(Sulphamoyl)-Amino]-Ethoxy}-Ethyl)-Carbamoyl]-7H-Indolo-{2,1-a]-[2]-Benzazepine-10-Carboxylic Acid
    Publication number: 20150329482
    Abstract: The present invention relates to an improved method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid. The present invention also relates to a new compound, namely tent-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate, used in this improved method.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 19, 2015
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: Tom Cornelis Hortense Govaerts, Jean-Pierre-Andre Marc Bongartz, Patrick Hubert J. Nieste
  • Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7-indolo-[2,1-]-[2]-benzazepine-10-carboxylic acid
    Patent number: 9127010
    Abstract: The present invention relates to an improved method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid. The present invention also relates to a new compound, namely tert-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate, used in this improved method.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 8, 2015
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tom Cornelis Hortense Govaerts, Jean-Pierre-Andre Marc Bongartz, Patrick Hubert J. Nieste
  • Process for the preparation of compounds useful as inhibitors of SGLT
    Patent number: 9056850
    Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: June 16, 2015
    Assignees: Janssen Pharmaceutica N.V., Mitsubishi Tanabe Pharma Corporation
    Inventors: Walter Ferdinand Maria Filliers, Rudy Laurent Maria Broeckx, Patrick Hubert J. Nieste, Masanori Hatsuda, Masahiko Yoshinaga, Mitsuhiro Yada, Christopher Teleha
  • CRYSTALLINE Pl3 KINASE INHIBITORS
    Publication number: 20150105408
    Abstract: There is provided inter alia 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide in the form of a solid crystalline hydrate and in solid crystalline anhydrous form. There are also provided dry powder pharmaceutical compositions for inhalation containing such solid crystalline forms.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 16, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert, J Nieste, Alex Herman Copmans, Filip Marcel Vanhoutte, Carina Leys
  • NOVEL PHARMACEUTICAL FORMULATIONS
    Publication number: 20150099768
    Abstract: There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 9, 2015
    Inventors: Rudy Laurent Maria Broeckx, Walter Ferdinand Maria Filliers, Patrick Hubert J. Nieste, Alex Herman Copmans, Filip Marcel C. Vanhoutte, Carina Leys
  • PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2--ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
    Publication number: 20130102777
    Abstract: The present invention relates to an improved method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid. The present invention also relates to a new compound, namely tert-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate, used in this improved method.
    Type: Application
    Filed: June 24, 2011
    Publication date: April 25, 2013
    Applicant: JANSSEN R&D IRELAND
    Inventors: Tom Cornelis Hortense Govaerts, Jean-Pierre-Andre Marc Bongartz, Patrick Hubert J. Nieste
  • PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT
    Publication number: 20100099883
    Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
    Type: Application
    Filed: October 14, 2009
    Publication date: April 22, 2010
    Inventors: Walter Ferdinand Maria Fillers, Rudy Laurent Maria Broeckx, Patrick Hubert J. Nieste, Masanori Hatsuda, Masahiko Yoshinaga, Mitsuhiro Yada