Abstract: The present disclosure provides a hyaluronic acid-based drug delivery system comprising a compound of Formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein X, R1, and R2 are as defined herein. The present disclosure also provides compositions comprising the hyaluronic acid-based drug delivery system described herein and one or more active pharmaceutical ingredient(s). The present disclosure also provides methods of delivering one or more active pharmaceutical ingredient(s) to the eye of a subject in need thereof and methods of treating ophthalmic diseases, disorders, or conditions in a subject in need thereof, comprising administering a composition disclosed herein to the subject.

Abstract: Methods, systems, and apparatus for automated building maintenance management using a digital representation of a physical building. A controller, operating an AI engine one or both of a GAN engine and a ViT, receives a design plan comprising dynamic components representing as-built building elements. Metadata, including historical maintenance logs, component specifications from a component database, sensor data from a Building Management System (BMS), and environmental conditions, is associated with the dynamic components. The controller detects maintenance requirements for the dynamic components based on sensor anomalies, historical failure patterns, metadata, and user inputs, determines interrelations between the dynamic components, and assigns priority levels to the maintenance tasks. A maintenance execution plan is generated, incorporating task prioritization, labor allocation, material requirements, and execution timelines.

Abstract: Apparatus comprising a processor and memory storing executable code operative to receive a building design plan, generate a user interactive interface with dynamic components representing aspects of the design, and enable user manipulation of design parameters. The apparatus calculates and displays a maximum occupancy load and the maximum length of a longest possible egress path based on the design plan and user modifications. The system identifies boundaries, use types, and points of egress, recalculates metrics in real time as the user adjusts design features, and references code-specific parameters for compliance. Automated suggestions for design modifications are provided to achieve code compliance. The apparatus further generates reports summarizing occupancy load, egress path length, compliance status, and recommended changes, supporting efficient building code analysis and design optimization.

Abstract: Apparatus operative via executable software to quantify building metrics using artificial intelligence analysis of a design plan. A design plan is represented using multiple dynamic components. Each dynamic component may include a parameter changeable via the user interactive interface. The dynamic components may be arranged in a user interactive interface to form a first set of boundaries, including a respective length and area, and defining at least a portion of a first unit. AI is used to determine a longest path of egress and a supportable occupancy load that may be used to determine compliance with parameters of a given code. The AI may assess whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: AI-powered apparatus for code compliance related annotation of design plans. A controller and processor receive and analyze a two-dimensional representation of a building design plan. An AI engine identifies design elements such as architectural aspects, walls, and boundaries, represented as pixel patterns. A user interface displays these elements, allowing users to select and annotate them. The system determines positional coordinates for selected elements, updating annotations in real-time to ensure synchronicity across the collaborative environment. The AI engine provides automated annotation suggestions and prioritizes actions based on annotation severity. It compares annotations against a database of safety codes to identify non-compliance issues, alerting users and suggesting adjustments. The apparatus supports real-time collaboration, 3D visualization, and integration with third-party platforms for code compliance services, enhancing workflow efficiency and ensuring adherence to regulatory standards.

Abstract: Methods and apparatus for spatial annotation of design plans in an AI-powered collaborative environment. It includes a controller to receive a static representation of a building's design plan and an AI engine to analyze raster images to identify design elements such as architectural aspects, walls, and rooms. An interactive user interface generates polygons and lines representing these elements, allowing users to select elements for annotation. The apparatus determines positional coordinates of selected elements, links annotations to these coordinates, and updates the interface in real-time for multiple users. Additional features include automated annotation suggestions, user interaction options like commenting and approval, and learning from user interactions to enhance future annotations. The apparatus can detect physical changes in design elements using cameras and update the interface accordingly. It supports dynamic collaboration and enhances the accuracy and efficiency of design plan annotations.

Abstract: Various embodiments may provide communication security at a physical layer. In some embodiments, a first wireless device at a first location may transmit to a second wireless device at a second location different portions of a message via two or more different spatially separated signal paths in a manner that enables the second wireless device to receive the complete message but prevents reception of the complete message by a third wireless device at a third location different from the second location. The second wireless device may receive different portions of the message via the two or more different spatially separated signal paths, may assemble the message from the received different portions of the message.

Abstract: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.

Abstract: Apparatus operative via executable software to quantify building metrics using artificial intelligence analysis of a design plan. A design plan is represented using multiple dynamic components. Each dynamic component may include a parameter changeable via the user interactive interface. The dynamic components may be arranged in a user interactive interface to form a first set of boundaries, including a respective length and area, and defining at least a portion of a first unit. AI is used to determine a longest path of egress and a supportable occupancy load that may be used to determine compliance with parameters of a given code. The AI may assess whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: A system for processing semiconductor wafers, the system including: a processing chamber; a heat source; a substrate holder configured to expose a semiconductor wafer to the heat source; a first electrode configured to be detachably coupled to a first major surface of a semiconductor wafer; and a second electrode coupled to the substrate holder, the first electrode and the second electrode together configured to apply an electric field in the semiconductor wafer.

Abstract: A method of fabricating a semiconductor device includes placing a semiconductor wafer into a processing chamber, the semiconductor wafer including a first conductive layer and a second conductive layer separated by an intermediate layer; applying an electrical bias voltage across the intermediate layer by coupling the first conductive layer to a first potential and coupling the second conductive layer to a second potential; and annealing the semiconductor wafer while applying the electrical bias voltage.

Abstract: Artificial Intelligence systems receive two dimensional design plans (e.g., physical, or electronic documents) that are processed to mimic the perception, learning, problem-solving, and decision-making formerly performed by human workers assessing the design plans for compliance with an applicable code. AI analysis converts vector images into patterns that are conducive to machine learning and generates a dynamic interface that allows a user to interact with the AI findings. The AI assesses whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: Methods and apparatus operative to quantify building metrics using artificial intelligence analysis of a design plan. A design plan is represented using multiple dynamic components. Each dynamic component may include a parameter changeable via the user interactive interface. The dynamic components may be arranged in a user interactive interface to form a first set of boundaries, including a respective length and area, and defining at least a portion of a first unit. AI may determine a longest path of egress and a supportable occupancy load that may be used to determine compliance with parameters of a given code. The AI may assess whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: Provided herein are poly(ether ester) multi-block copolymers (PEE-MBCP). Also provided herein are injectable delivery systems or pharmaceutical compositions, comprising a PEE-MBCP provided herein, either alone or in combination with a binding protein, such as abicipar. Also provided herein are methods of using these injectable delivery systems or pharmaceutical compositions provided herein for the treatment of ocular disorders.

Abstract: Methods and apparatus operative to quantify building metrics using artificial intelligence analysis of a design plan. A design plan is represented using multiple dynamic components. Each dynamic component may include a parameter changeable via the user interactive interface. The dynamic components may be arranged in a user interactive interface to form a first set of boundaries, including a respective length and area, and defining at least a portion of a first unit. AI may determine a longest path of egress and a supportable occupancy load that may be used to determine compliance with parameters of a given code. The AI may assess whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: Methods and apparatus for processing two dimensional references using artificial intelligence to generate requirements of a construction project. A two-dimensional reference, such as an architectural floor plan is provided as input to a controller operative to be an artificial intelligence engine (AI engine). The AI engine generates a user interactive interface and quantities of items, such as net floor space of a room or a region, which may be used to manage construction projects.

Abstract: Artificial Intelligence systems receive two dimensional design plans (e.g., physical, or electronic documents) that are processed to mimic the perception, learning, problem-solving, and decision-making formerly performed by human workers assessing the design plans for compliance with an applicable code. AI analysis converts vector images into patterns that are conducive to machine learning and generates a dynamic interface that allows a user to interact with the AI findings. The AI assesses whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: A method of fabricating a semiconductor device includes placing a semiconductor wafer into a processing chamber, the semiconductor wafer including a first conductive layer and a second conductive layer separated by an intermediate layer; applying an electrical bias voltage across the intermediate layer by coupling the first conductive layer to a first potential and coupling the second conductive layer to a second potential; and annealing the semiconductor wafer while applying the electrical bias voltage.

Abstract: A method of fabricating a semiconductor device includes placing a semiconductor wafer into a processing chamber, the semiconductor wafer including a first conductive layer and a second conductive layer separated by an intermediate layer; applying an electrical bias voltage across the intermediate layer by coupling the first conductive layer to a first potential and coupling the second conductive layer to a second potential; and annealing the semiconductor wafer while applying the electrical bias voltage.

Abstract: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.