Patents by Inventor Patrick J. Burke

Patrick J. Burke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATORY ANTIBODY-DRUG CONJUGATES
    Publication number: 20240123079
    Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.
    Type: Application
    Filed: July 14, 2023
    Publication date: April 18, 2024
    Inventors: Adam G. Hill, Elizabeth E. Gray, Elizabeth J. Cummins, Patrick J. Burke, Shyra J. Gardai
  • Conjugates of quaternized tubulysin compounds
    Patent number: 11793880
    Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: October 24, 2023
    Assignee: Seagen Inc.
    Inventors: Patrick J. Burke, Joel Courter
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20230055475
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: March 18, 2022
    Publication date: February 23, 2023
    Inventors: Stephen C. ALLEY, Scott C. JEFFREY, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS
    Publication number: 20220226482
    Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
    Type: Application
    Filed: November 22, 2021
    Publication date: July 21, 2022
    Inventors: Patrick J. BURKE, Joel COURTER
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 11319526
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 3, 2022
    Assignee: Seagen Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Conjugates of quaternized tubulysin compounds
    Patent number: 11229708
    Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: January 25, 2022
    Assignee: SEAGEN INC.
    Inventors: Patrick J. Burke, Joel Courter
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 10443035
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 15, 2019
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20190276796
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: May 16, 2019
    Publication date: September 12, 2019
    Inventors: Stephen C. ALLEY, Scott C. JEFFREY, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS
    Publication number: 20190015517
    Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
    Type: Application
    Filed: December 2, 2016
    Publication date: January 17, 2019
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Patrick J. Burke, Joel Courter
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20180155677
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: October 10, 2017
    Publication date: June 7, 2018
    Inventors: Stephen C. ALLEY, Scott C. Jeffrey, Django SUSSMAN, Dennis R. BENJAMIN, Brian TOKI, Patrick J. BURKE
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 9816069
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 14, 2017
    Assignee: SEATTLE GENETICS, INC.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES
    Publication number: 20170247412
    Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
    Type: Application
    Filed: September 10, 2015
    Publication date: August 31, 2017
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Patrick J. Burke, Scott Jeffrey, Joseph Z. Hamilton
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20150337259
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: February 26, 2015
    Publication date: November 26, 2015
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8993326
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: March 31, 2015
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20140031536
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: October 1, 2013
    Publication date: January 30, 2014
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8574907
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: November 5, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20120183997
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: February 24, 2012
    Publication date: July 19, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: STEPHEN C. ALLEY, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
    Patent number: 8163551
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: April 24, 2012
    Assignee: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
    Publication number: 20090317869
    Abstract: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.
    Type: Application
    Filed: May 1, 2009
    Publication date: December 24, 2009
    Applicant: Seattle Genetics, Inc.
    Inventors: Stephen C. Alley, Scott C. Jeffrey, Django Sussman, Dennis R. Benjamin, Brian Toki, Patrick J. Burke
  • Method and apparatus for separating two optical fibers
    Patent number: 6701057
    Abstract: A method and apparatus for separating a first and second optical fibers including a fiber feed mechanism adapted to feed the first optical fiber and the second optical fiber, and a nozzle adapted to provide a displacing force on the second optical fiber, where the second optical fiber is displaced away from the first optical fiber to thereby separate the second optical fiber from the first optical fiber. In one embodiment, the displacing force is provided by a gas stream directed away from the nozzle while in another embodiment, the displacing force is directed towards the nozzle. In another embodiment, the apparatus includes a separation mechanism with a first guide, a second guide, a guide separator, and a deflector plate. In another embodiment, the apparatus includes a clamp mechanism with a first clamping pad having an offset extension that extends beyond an edge of a second clamp pad.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: March 2, 2004
    Assignee: Corning Incorporated
    Inventors: Patrick J. Burke, William J. Miller, Mark L. Morrell