Patents by Inventor Patrick J. Dillon
Patrick J. Dillon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030092893Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 20, 2001Publication date: May 15, 2003Applicant: Human Genome Sciences, Inc.Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
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Publication number: 20030077694Abstract: The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.Type: ApplicationFiled: May 19, 1999Publication date: April 24, 2003Inventors: GUO-LIANG YU, JIAN NI, VISHVA DIXIT, REINER L. GENTZ, PATRICK J. DILLON
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Publication number: 20030077695Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.Type: ApplicationFiled: July 1, 1999Publication date: April 24, 2003Applicant: HUMAN GENOME SCIENCES, INC.Inventors: STEVEN M. RUBEN, PABLO JIMENEZ, D. ROXANNE DUAN, MARK A. RAMPY, DONNA MENDRICK, JUN ZHANG, JIAN NI, PAUL A. MOORE, TIMOTHY A. COLEMAN, JOACHIM R. GRUBER, PATRICK J. DILLON, REINER L. GENTZ
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Publication number: 20030065160Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: ApplicationFiled: December 7, 2001Publication date: April 3, 2003Applicant: Human Genome Sciences, Inc.Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
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Patent number: 6541452Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.Type: GrantFiled: November 28, 2000Date of Patent: April 1, 2003Assignee: Human Genome Sciences, Inc.Inventors: Gregg A. Hastings, Timothy A. Coleman, Daniel A. Lawrence, Patrick J. Dillon
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Patent number: 6541224Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: June 14, 2001Date of Patent: April 1, 2003Assignee: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz, Patrick J. Dillon
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Publication number: 20030054436Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: January 3, 1997Publication date: March 20, 2003Inventors: CHARLES A. KUNSCH, GIL A. CHOI, STEVEN C. BARASH, PATRICK J. DILLON, MICHAEL R. FANNON, CRAIG A. ROSEN
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Patent number: 6531447Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: October 18, 2000Date of Patent: March 11, 2003Assignee: Human Genome Sciences, Inc.Inventors: Steven M. Ruben, Craig A. Rosen, Kenneth C. Carter, Patrick J. Dillon, Gregory A. Endress, Guo-Liang Yu, Jian Ni, Ping Feng
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Patent number: 6525174Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.Type: GrantFiled: December 4, 1998Date of Patent: February 25, 2003Assignee: Human Genome Sciences, Inc.Inventors: Paul Young, John M. Greene, Ann M. Ferrie, Steven M. Ruben, Craig A. Rosen, Jing-Shan Hu, Henrik S. Olsen, Reinhard Ebner, Laurie A. Brewer, Paul A. Moore, Yanggu Shi, Charles Florence, Kimberly Florence, David W. Lafleur, Jian Ni, Ping Fan, Ying-Fei Wei, Carrie L. Fischer, Daniel R. Soppet, Yi Li, Zhizhen Zeng, Hla Kyaw, Guo-Liang Yu, Ping Feng, Patrick J. Dillon, Gregory A. Endress, Kenneth C. Carter
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Publication number: 20030023068Abstract: The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.Type: ApplicationFiled: February 21, 2002Publication date: January 30, 2003Applicant: Human Genome SciencesInventors: Guo-Liang Yu, Patrick J. Dillon, Reinhard Ebner, Gregory A. Endress
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Patent number: 6509170Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: March 12, 1997Date of Patent: January 21, 2003Assignee: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Jian Ni, Reiner Gentz, Patrick J. Dillon
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Patent number: 6506882Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: GrantFiled: February 26, 2002Date of Patent: January 14, 2003Assignee: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Jian Ni, Reiner Gentz, Patrick J. Dillon
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Publication number: 20020192749Abstract: The present invention relates to novel human human polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human human polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human human polypeptides.Type: ApplicationFiled: October 3, 2001Publication date: December 19, 2002Inventors: Paul A. Moore, Timothy A. Coleman, Reiner L. Gentz, Patrick J. Dillon, Jian Ni, Yi Li, Gregory A. Endress, Daniel R. Soppet
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Publication number: 20020147149Abstract: The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: May 24, 2002Publication date: October 10, 2002Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz, Patrick J. Dillon
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Publication number: 20020127651Abstract: The invention relates to h4-1BBSV receptor polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: March 15, 2002Publication date: September 12, 2002Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Guo-Liang Yu, Reiner L. Gentz, Patrick J. Dillon
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Publication number: 20020119528Abstract: Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.Type: ApplicationFiled: November 7, 2001Publication date: August 29, 2002Applicant: Human Genome Sciences, Inc.Inventors: Jian Ni, Reiner Gentz, Guo-Liang Yu, Jeffrey Su, Patrick J. Dillon
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Publication number: 20020120116Abstract: The present invention provides polynucleotide sequences of the genome of Enterococcus faecalis, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: May 4, 1998Publication date: August 29, 2002Inventors: CHARLES A. KUNSCH, PATRICK J. DILLON, STEVEN BARASH
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Publication number: 20020119554Abstract: The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: September 14, 2001Publication date: August 29, 2002Inventors: Joseph G. Vockley, Patrick J. Dillon
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Publication number: 20020110850Abstract: A DNA sequence of SEQ ID NOS:1-12483. An isolated DNA sequence containing the coding region of a human gene and a DNA sequence identified in SEQ ID NOS:1-12483. An isolated DNA sequence containing the coding region of a human gene that contains a DNA sequence present in ATCC Deposit No. 75916. A DNA sequence hybridizable with a DNA sequence of SEQ ID NOS:1-12483 and isolatable from other DNA in ATCC Deposit No. 75916. Expression vectors containing any of the above. Proteins expressed from any of the above.Type: ApplicationFiled: February 15, 2001Publication date: August 15, 2002Inventors: Craig A. Rosen, Steven M. Ruben, Patrick J. Dillon, Haodong Li, William A. Haseltine
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Publication number: 20020106695Abstract: The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.Type: ApplicationFiled: February 26, 2002Publication date: August 8, 2002Applicant: Human Genome Sciences, Inc.Inventors: Guo-Liang Yu, Jian Ni, Reiner L. Gentz, Patrick J. Dillon