Patents by Inventor Patrick J. Grohar

Patrick J. Grohar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the treatment of SWI-SNF mutant tumors
    Patent number: 12648957
    Abstract: The present disclosure is directed to the use of mithramycin analogues to treat cancers having mutations in the SWI/SNF pathway, such as rhabdoid cancers with mutations in SMARCB1.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: June 9, 2026
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Patrick J. Grohar, Maggie H. Chasse, Elissa Ann Levine
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF SWI-SNF MUTANT TUMORS
    Publication number: 20220296622
    Abstract: The present disclosure is directed to the use of mithramycin analogs to treat cancers having mutations in the SWI/SNF (SWItch/Sucrose Non-Fermentable) pathway, such as rhabdoid cancers with mutations in SMARCB1 (BAF47, INI1, SNF5), wherein mithramycin analogs comprising EC-8042. Further disclosed are methods of treating cancer comprising treating the subject with a second cancer therapy.
    Type: Application
    Filed: September 16, 2020
    Publication date: September 22, 2022
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Patrick J. Grohar, Maggie H. CHASSE, Elissa Ann LEVINE